Transcatheter intraarterial therapies have proved valuable in the battle against primary and secondary hepatic malignancies; the unique aspects of all such therapies are their minimal toxicity prof... Transcatheter intraarterial therapies have proved valuable in the battle against primary and secondary hepatic malignancies. The unique aspects of all such therapies are their reduced toxicity prof...

Background Hepatocellular carcinoma (HCC) is a common cause of worldwide mortality. Transarterial radioembolization (TARE) with yttrium-90 (Y90), a transcatheter intra-arterial procedure performed by interventional radiology, has become widely utilized in managing HCC. Methods The following is a focused review of TARE covering its commercially available products, clinical considerations of treatment, salient clinical trial data establishing its utility, and the current and future roles of TARE in the management of HCC. Results TARE is indicated for patients with unresectable, intermediate stage HCC. The two available products are glass and resin microspheres. All patients undergoing TARE must be assessed with a history, physical examination, clinical laboratory tests, imaging, and arteriography with macroaggregated albumin. TARE is safe and effective in the treatment of unresectable HCC, as it has a safer toxicity profile than chemoembolization, longer time-to-progression, greater ability to downsize and/or bridge patients to liver transplant, and utility in tumor complicated by portal vein thrombosis. TARE can also serve as an alternative to ablation and chemotherapy. Conclusion TARE assumes an integral role in the management of unresectable HCC and has been validated by numerous studies.

The CT/MRI Liver Imaging Reporting and Data System version 2024 Treatment Response Assessment (TRA) algorithm now has two independent cores with tailored TRA criteria after nonradiation or radiation-based liver-directed therapy and incorporates MRI ancillary features (diffusion restriction and mild to moderate T2 hyperintensity).

Knowledge of the evolving methods of transarterial radioembolization and the tools to assess posttreatment imaging and response is essential for radiologists to optimize this therapeutic option for... Transarterial radioembolization (TARE) with yttrium 90 has increasingly been performed to treat hepatocellular carcinoma (HCC). TARE was historically used as a palliative lobar therapy for patients...