Objective: In this study we investigate the effects of preconception endurance training with or without voluntary exercise during pregnancy on indices of bone formation and resorption in female offspring bone. Methods: Twenty four C57BL/6 female mice randomly divided into four groups: trained in preconception period and exercised during pregnancy (TE); trained in preconception periods but unexercised during pregnancy (TC); untrained in preconception periods but exercised during pregnancy (CE); untrained and unexercised (CC). Trained dams were subjected to a protocol of moderate exercise training over a period of 4 weeks before pregnancy. Analyses were performed on the adult female offspring that did not have access to running wheels in any portion of their lives. Results: The OPG, Runx2, COLI, ALP and OPN mRNA expression was significantly up-regulated in offspring born to dams that trained in preconception period. However, there was no significant difference in OPG, COLI, Runx2 and ALP expression in TE and TC offspring (P > 0.05). RANKL and osteocalcin expression were significantly down-regulated in TE offspring group (P < 0.001). Conclusions: Improved physical fitness in preconception period results in significant changes in bone gene expressions of female offspring, in particular towards osteogenic responses with improved RANKL/OPG ratio.

Background: The present study aimed at demonstrating the heat stress situation (distribution and intensity) based on a standard and common heat stress index, Wet Bulb Globe Temperature (WBGT), during hot seasons and interpret the obtained results considering global warming and rising temperature in different parts of the country based on climate changes studied in Iran. Methods: Heat stress assessment was done using WBGT index. Environmental parameters were measured simultaneously in the early, middle and end of shift work. The personal parameters including cloth thermal insulation and metabolic rate of 242 participants from 9 climatic categories were recorded for estimating effective WBGT (measured WBGT plus cloth adjustment factor as well as metabolic rate effect). The values of the indicator were categorized in the statistical software media and then linked to the climatic zoning of the data in the GIS information layers, in which, WBGT values relating to selected stations were given generalization to similar climatic regionalization. Results: The obtained results showed that in the summer about 60 % and more than 75 % of the measurements relating to 12 pm and 3 pm, respectively, were in heat stress situations (i.e. the average amount of heat stress index was higher than 28 °C). These values were found to be about 20–25 % in the spring. Moreover, only in the early hours of shift work in spring could safe conditions be seen throughout the country. This situation gradually decreased in the middle of the day hours and was replaced by the warning status and stress. And finally, in the final hours of shift work thermal stresses reached their peaks. These conditions for the summer were worse. Conclusions: Regarding several studies related to climate change in Iran and the results of present study, heat stress, especially in the central and southern parts of Iran, can be exacerbated in the decades to come if climate change and rising temperature occurs. Therefore, paying attention to this critical issue and adopting macro-management policies and programs in the field of workplace health is essential.

Aim. Exercise is commonly cited as a remedy for menstrual symptoms. The purpose of the present study was to evaluate the effect of a period of exercise on physical and psychological symptoms of menstruation, dysmenorrhea, oligomenorrhea and amenorrhea. Methods. Participants of the study were 250 students of Shiraz University who enrolled in a fitness course. The study design was semi-experimental with one group. Prior and after 12 weeks of a physical fitness program, our subjects completed questionnaires on menstrual distress. The physical fitness training program included physical fitness exercises (cardiovascular endurance, muscular endurance, agility, speed, strength; duration: 90 min, frequency: twice weekly, intensity: 50 to 70% of maximum heart rate). The t test was used for analysis of the data. Results. Physical premenstrual symptoms (p = 0.005), psychological premenstrual symptoms (p = 0.019), dysmenorrhea (p = 0.0001) and oligomenorrhea (p = 0.034) were significantly reduced after the training program. There was no difference in the incidence of amenorrhea before and after the training program (p = 0.162). Conclusion. Our findings indicate that selected physical fitness exercises positively influenced menstrual symptoms.