With the advent of autonomous vehicles society will need to confront a new set of risks which, for the first time, includes the ability of socially embedded forms of artificial intelligence to make complex risk mitigation decisions: decisions that will ultimately engender tangible life and death consequences. Since AI decisionality is inherently different to human decision-making processes, questions are therefore raised regarding how AI weighs decisions, how we are to mediate these decisions, and what such decisions mean in relation to others. Therefore, society, policy, and end-users, need to fully understand such differences. While AI decisions can be contextualised to specific meanings, significant challenges remain in terms of the technology of AI decisionality, the conceptualisation of AI decisions, and the extent to which various actors understand them. This is particularly acute in terms of analysing the benefits and risks of AI decisions. Due to the potential safety benefits, autonomous vehicles are often presented as significant risk mitigation technologies. There is also a need to understand the potential new risks which autonomous vehicle driving decisions may present. Such new risks are framed as decisional limitations in that artificial driving intelligence will lack certain decisional capacities. This is most evident in the inability to annotate and categorise the driving environment in terms of human values and moral understanding. In both cases there is a need to scrutinise how autonomous vehicle decisional capacity is conceptually framed and how this, in turn, impacts a wider grasp of the technology in terms of risks and benefits. This paper interrogates the significant shortcomings in the current framing of the debate, both in terms of safety discussions and in consideration of AI as a moral actor, and offers a number of ways forward.

Machine Learning (ML) techniques have been applied in the field of nanotoxicology with very encouraging results. Adverse effects of nanoforms are affected by multiple features described by theoretical descriptors, nano-specific measured properties, and experimental conditions. ML has been proven very helpful in this field in order to gain an insight into features effecting toxicity, predicting possible adverse effects as part of proactive risk analysis, and informing safe design. At this juncture, it is important to document and categorize the work that has been carried out. This study investigates and bookmarks ML methodologies used to predict nano (eco)-toxicological outcomes in nanotoxicology during the last decade. It provides a review of the sequenced steps involved in implementing an ML model, from data pre-processing, to model implementation, model validation, and applicability domain. The review gathers and presents the step-wise information on techniques and procedures of existing models that can be used readily to assemble new nanotoxicological in silico studies and accelerates the regulation of in silico tools in nanotoxicology. ML applications in nanotoxicology comprise an active and diverse collection of ongoing efforts, although it is still in their early steps toward a scientific accord, subsequent guidelines, and regulation adoption. This study is an important bookend to a decade of ML applications to nanotoxicology and serves as a useful guide to further in silico applications.

The emergence and rapid spread of multidrug-resistant bacteria strains are a public health concern. This emergence is caused by the overuse and misuse of antibiotics leading to the evolution of antibiotic-resistant strains. Nanoparticles (NPs) are objects with all three external dimensions in the nanoscale that varies from 1 to 100 nm. Research on NPs with enhanced antimicrobial activity as alternatives to antibiotics has grown due to the increased incidence of nosocomial and community acquired infections caused by pathogens. Machine learning (ML) tools have been used in the field of nanoinformatics with promising results. As a consequence of evident achievements on a wide range of predictive tasks, ML techniques are attracting significant interest across a variety of stakeholders. In this article, we present an ML tool that successfully predicts the antibacterial capacity of NPs while the model’s validation demonstrates encouraging results (R² = 0.78). The data were compiled after a literature review of 60 articles and consist of key physico-chemical (p-chem) properties and experimental conditions (exposure variables and bacterial clustering) from in vitro studies. Following data homogenization and pre-processing, we trained various regression algorithms and we validated them using diverse performance metrics. Finally, an important attribute evaluation, which ranks the attributes that are most important in predicting the outcome, was performed. The attribute importance revealed that NP core size, the exposure dose, and the species of bacterium are key variables in predicting the antibacterial effect of NPs. This tool assists various stakeholders and scientists in predicting the antibacterial effects of NPs based on their p-chem properties and diverse exposure settings. This concept also aids the safe-by-design paradigm by incorporating functionality tools.

Explainable Artificial Intelligence (XAI) models allow for a more transparent and understandable relationship between humans and machines. The insurance industry represents a fundamental opportunity to demonstrate the potential of XAI, with the industry’s vast stores of sensitive data on policyholders and centrality in societal progress and innovation. This paper analyses current Artificial Intelligence (AI) applications in insurance industry practices and insurance research to assess their degree of explainability. Using search terms representative of (X)AI applications in insurance, 419 original research articles were screened from IEEE Xplore, ACM Digital Library, Scopus, Web of Science and Business Source Complete and EconLit. The resulting 103 articles (between the years 2000–2021) representing the current state-of-the-art of XAI in insurance literature are analysed and classified, highlighting the prevalence of XAI methods at the various stages of the insurance value chain. The study finds that XAI methods are particularly prevalent in claims management, underwriting and actuarial pricing practices. Simplification methods, called knowledge distillation and rule extraction, are identified as the primary XAI technique used within the insurance value chain. This is important as the combination of large models to create a smaller, more manageable model with distinct association rules aids in building XAI models which are regularly understandable. XAI is an important evolution of AI to ensure trust, transparency and moral values are embedded within the system’s ecosystem. The assessment of these XAI foci in the context of the insurance industry proves a worthwhile exploration into the unique advantages of XAI, highlighting to industry professionals, regulators and XAI developers where particular focus should be directed in the further development of XAI. This is the first study to analyse XAI’s current applications within the insurance industry, while simultaneously contributing to the interdisciplinary understanding of applied XAI. Advancing the literature on adequate XAI definitions, the authors propose an adapted definition of XAI informed by the systematic review of XAI literature in insurance.