Urszula Lewandowska

Prof. Dr. Urszula Lewandowska

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Academic Career Length

14Years (2013-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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10 December 2013 in Journal of Agricultural and Food Chemistry
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Journal Article
Closed access
ULUrszula Lewandowska
Urszula Lewandowska
KSKarolina Szewczyk
Karolina Szewczyk
EHElżbieta Hrabec
Elżbieta Hrabec
AJAnna Janecka
Anna Janecka
SGSylwia Gorlach
Sylwia Gorlach
1 October 2015 in Cancer Letters
Verified
Journal Article
Closed access
SGSylwia Gorlach
Sylwia Gorlach
JFJakub Fichna
Jakub Fichna
ULUrszula Lewandowska
Urszula Lewandowska
12 April 2022 in International Journal of Molecular Sciences
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Journal Article
Open access
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MCMiłosz Caban
Miłosz Caban
KOKatarzyna Owczarek
Katarzyna Owczarek
ULUrszula Lewandowska
Urszula Lewandowska
Eye diseases are associated with visual impairment, reduced quality of life, and may even lead to vision loss. The efficacy of available treatment of eye diseases is not satisfactory. The unique environment of the eye related to anatomical and physiological barriers and constraints limits the bioavailability of existing agents. In turn, complex ethiopathogenesis of ocular disorders that used drugs generally are non-disease specific and do not act causally. Therefore, there is a need for the development of a new therapeutic and preventive approach. It seems that matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have a significant role in the development and progression of eye diseases and could be used in the therapy of these disorders as pharmacological targets. MMPs and TIMPs play an important role in the angiogenesis, epithelial-mesenchymal transition, cell invasion, and migration, which occur in ocular diseases. In this review, we aim to describe the participation of MMPs and TIMPs in the eye diseases, such as age-related macular degeneration, cataract, diabetic retinopathy, dry eye syndrome, glaucoma, and ocular cancers, posterior capsule opacification focusing on potential mechanisms.
14 July 2022 in Journal of Functional Foods
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Journal Article
Open access
MCMiłosz Caban
Miłosz Caban
ULUrszula Lewandowska
Urszula Lewandowska
1 June 2016 in Biochemical Pharmacology
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Journal Article
Closed access
ULUrszula Lewandowska
Urszula Lewandowska
JFJakub Fichna
Jakub Fichna
SGSylwia Gorlach
Sylwia Gorlach
26 February 2013 in Nutrition and Cancer
Verified
Journal Article
Closed access
ULUrszula Lewandowska
Urszula Lewandowska
KSKarolina Szewczyk
Karolina Szewczyk
KOKatarzyna Owczarek
Katarzyna Owczarek
ZHZbigniew Hrabec
Zbigniew Hrabec
APAnna Podsedek
Anna Podsedek
EHElżbieta Hrabec
Elżbieta Hrabec
Polyphenols are natural compounds of high structural diversity which translates into a very wide spectrum of biological activities, including chemoprevention. Here we report that a Japanese quince fruit flavanol preparation (JQFFP) caused favorable changes in Bax/Bcl-2 mRNA ratio, which rendered normal and cancer cells more resistant and more sensitive, respectively, to apoptosis. DU145 human prostate cancer cells were characterized by the most advantageous Bax/Bcl-2 ratio. The growth and invasiveness of MDA-MB-231 human breast cancer cells were strongly suppressed by JQFFP, which was accompanied with a decrease in MMP-9 activity and stimulation of TIMP-1 expression. Importantly, JQFFP did not decrease normal human prostate PNT1A cell number, whereas Bax/Bcl-2 ratio decreased which implies increased resistance to apoptosis. In conclusion, JQFFP exhibited a potent antiproliferative effect against cancer cells, inhibited their invasiveness, and decreased expression level of several genes involved in apoptosis, angiogenesis, and metastasis.