This paper describes the design and function of an application that enables vulnerable people to provide medical information for use in disasters, and presents the results of an initial test of its usability in Nankoku, Japan. The application consists of two parts: K-DiPS Solo, a smartphone app, and K-DiPS Online, a web application for disaster management by local governments. We asked vulnerable people or their family caregivers to enter medical information into the app on their smartphones and connected this information to a local government application as a demonstration of a disaster response solution that manages information. We targeted a group of 14 healthy older people. The user information that they entered into the app was stored in the cloud via the communication system of the mobile phone. A ledger of vulnerable people for use in the event of a disaster was automatically created on the web application using the information supplied by the individuals. Local government staff corrected the location information, if necessary, by dragging points plotted on a map. This disaster response solution was shown to connect individuals to government offices, and to enable a consistent flow of information from patient details to stocking of supplies, and for simulation, training, and response during disasters.

This study investigated factors affecting disaster preparedness and evacuation intentions among home-care patients dependent on electrical power for life support. Health professionals interviewed 53 home-care patients using the Kanazawa and Kochi Disaster Preparedness Checklist. About half of the participants requiring continuous artificial ventilation or aspiration indicated that they would not or could not evacuate following a disaster—even though their lives could be at risk. The availability of emergency medical equipment for use during a power outage was positively associated with the desire to evacuate. Our results indicate the need for improved systems to assist power-dependent home-care patients.

In the current study, we sought to identify special needs and safe evacuation conditions for children with neurodevelopmental disorders (CNDs) along Japan’s tsunami-prone Pacific coast. A survey and spatial analysis were used to collect data of CNDs (n = 47) and their caregivers. Areas predicted to be flooded in a tsunami, as well as evacuation routes to emergency shelters for vulnerable people (ESVPs), were mapped using geographic information systems (GIS). Our results showed that five professional staff were needed to support 33 CNDs requiring 135.9 m² of ESVP space. Critical safety factors were altitude, vertical evacuation, accessibility to ESVPs, and nonexistence of estuaries in the direction of evacuation. GIS-based spatial analysis and evacuation modeling for disaster preparedness and training plans that involve nurses are essential.

A series of 4-anilinopyrazolopyridine derivatives were synthesized and biologically evaluated as inhibitors of phosphodiesterase (PDE4). Chemical modification of 3, a structurally new chemical lead that was found in our in-house library, was focused on 1- and 3-substituents. Full details of the discovery of a new orally active chemical lead 5 are presented. Structure–activity relationship data, pharmacological evaluation, and the subtype selectivity study are also presented.