Prof. Dr. Santiago Gomez-Ruiz
Department of Biology, Geology, Physics and Inorganic Chemistry, Universidad Rey Juan Carlos, Mostoles, Spain
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Academic Career Length
24Years (2003-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 April 2016 in Coordination Chemistry Reviews
Journal Article
WWWaseem A. Wani
Waseem A. Wani
SPSanjiv Prashar
Sanjiv PrasharSSSheikh Shreaz
Sheikh Shreaz
Santiago Gomez-Ruiz12 July 2012 in Bioinorganic Chemistry and Applications
Journal Article
Santiago Gomez-RuizDMDanijela Maksimović-Ivanić
Danijela Maksimović-IvanićSMSanja Mijatović
Sanja Mijatović
Goran KaluđerovićThe purpose of this paper is to summarize mode of action of cisplatin on the tumor cells, a brief outlook on the metallocene compounds as antitumor drugs as well as the future tendencies for the use of the latter in anticancer chemotherapy. Molecular mechanisms of cisplatin interaction with DNA, DNA repair mechanisms, and cellular proteins are discussed. Molecular background of the sensitivity and resistance to cisplatin, as well as its influence on the efficacy of the antitumor immune response was evaluated. Furthermore, herein are summarized some metallocenes (titanocene, vanadocene, molybdocene, ferrocene, and zirconocene) with high antitumor activity.
16 December 2015 in Biomaterials Science
Journal Article
RKRajesh Kotcherlakota
Rajesh Kotcherlakota
ABAyan Kumar Barui
Ayan Kumar BaruiSPSanjiv Prashar
Sanjiv PrasharMFMariano Fajardo
Mariano Fajardo
DBDavid Briones
David Briones
Santiago Gomez-Ruiz +2
In the present study, we report the delivery of anti-cancer drug curcumin to cancer cells using mesoporous silica materials. A series of mesoporous silica material based drug delivery systems (S2, S4 and S6) were first designed and developed through the amine functionalization of KIT-6, MSU-2 and MCM-41 followed by the loading of curcumin. The curcumin loaded materials were characterized with several physico-chemical techniques and thoroughly screened on cancer cells to evaluate their in vitro drug delivery efficacy. All the curcumin loaded silica materials exhibited higher cellular uptake and inhibition of cancer cell viability compared to pristine curcumin. The effective internalization of curcumin in cancer cells through the mesoporous silica materials initiated the generation of intracellular reactive oxygen species and the down regulation of poly ADP ribose polymerase (PARP) enzyme levels compared to free curcumin leading to the activation of apoptosis. This study shows that the anti-cancer activity of curcumin can be potentiated by loading onto mesoporous silica materials. Therefore, we strongly believe that mesoporous silica based curcumin loaded drug delivery systems may have future potential applications for the treatment of cancers.
1 June 2016 in Materials Science and Engineering: C
Journal Article
VBVishnu Sravan Bollu
Vishnu Sravan Bollu
ABAyan Kumar Barui
Ayan Kumar BaruiSMSujan K Mondal
Sujan K MondalSPSanjiv Prashar
Sanjiv PrasharMFMariano Fajardo
Mariano Fajardo
Santiago Gomez-Ruiz +3
Journal Article
YEYounes Ellahioui
Younes EllahiouiSPSanjiv Prashar
Sanjiv PrasharSantiago Gomez-RuizFor more than 100 years metal complexes have been extensively used in therapy and since the discovery of cisplatin the research in this field has expanded exponentially. The scientific community is always in search of new alternatives to platinum compounds and a wide variety of metallodrugs based on other metals have been reported with excellent therapeutic results. This short review focuses on the work that our research group has carried out since 2007 in collaboration with others and centers on the preparation of organogallium(III) compounds, organotin(IV) derivatives, and titanocene(IV) complexes together with the study of their cytotoxic anticancer properties.
14 May 2014 in Angewandte Chemie International Edition
Journal Article
MBMirna Z. Bulatović
Mirna Z. BulatovićDMDanijela Maksimović-Ivanić
Danijela Maksimović-IvanićCBChristian Bensing
Christian Bensing
Santiago Gomez-RuizDSDirk Steinborn
Dirk Steinborn
Goran Kaluđerović +7
About Me
Santiago Gómez-Ruiz (1978, Toledo, Spain) received his B.Sc. in Chemistry from the Universidad de Castilla La Mancha (Spain) (1996-2001). In 2003, he held a predoctoral position at laboratory of Prof. Hey-Hawkins at Leipzig University (Germany) as "Marie Curie Training Site Fellow", and in December 2004, he finished his Ph.D. thesis, focused on the synthesis and catalytic properties of novel metallocene complexes. He obtained one of the most prestigious postdoctoral research fellowships, from the renowned Alexander Von Humboldt Foundation (2006-2007). During that time he worked in the field of P-Chemistry, publishing several articles of high impact. In December 2007, he returned to URJC and started a new research topic based on the design and preparation of novel metallodrugs and nanostructured materials with biological applications against cancer. In August 2009 he was named as Professor of Inorganic Chemistry, and since February 2020, he has been a full Professor of Inorganic Chemistry (Catedrático de Universidad).
Starting in 2001, he has published over 175 research papers, been awarded two patents, participated in more than 20 research projects and has been principal investigator of a competitive Exchange Research Project with the University of Leipzig funded by DAAD and IP of three projects of the Ministry of Science and Innovation (MICIN-AEI, Spain).
He has also supervised six Ph.D. students and six M.Sc. students and several local or exchange researchers.