Prevention of musculoskeletal disorders is supported by use of slanted rather than horizontal pointing devices, but user acceptance of the former may be compromised due to lower perceived ease of use. This study compares subjectively rated usability (N = 37) for three sizes of slanted computer mice and includes a horizontal small conventional device as a reference. For a random subset of the sample (n = 10), objective usability parameters were also elicited. Participants followed a standard protocol which is based on executing graphical pointing, steering, and dragging tasks generated by a purpose-built software. Subjective ratings were collected for each of the four pointing devices tested. The three slanted devices differed in size but were chosen because of an approximately similar slant angle (around 50–60 degrees relative to the horizontal plane). Additionally, effectiveness and efficiency were objectively calculated based on data recorded for the graphical tasks’ software for a random subset of the participants (n = 10). The results unveil small differences in preference in some of the subjective usability parameters across hand size groups. This notwithstanding, the objective efficiency results are aligned with the subjective results, indicating consistency with the hypothesis that smaller slanted devices relative to the user’s hand size are easier to use than larger ones. Mean values of weighted efficiency recorded in the study range from 68% to 75%, with differences across devices coherent with preference rank orders.

Developing new manual computer pointing devices abiding to the requirements set out in ergonomic product design literature necessitates joining contributions from several areas, including the ergonomic guidelines applicable to hand tool design, human–system interaction, and certain user characteristics such as anthropometric data. Computer mice are hand tools enabling the interaction with the computer, for use by people from both sexes and practically all ages. Moreover, the PC mouse’s intensive usage is able to cause musculoskeletal disorders. This paper reports on a study aimed at developing new computer mouse shapes, reducing forearm pronation, and providing hand–palm holding, supported by a literature review and an adequate design methodology, starting from known shapes of commercial products, the traditional (horizontal) computer mouse, and the vertical computer mouse. In this regard, potential concepts were generated as solutions to the previously specified problem through a set of creative tasks based on the specifications. Four new shapes were proposed to be evaluated through an assessment matrix; as a result, two new PC mice geometries were designed and fully prototyped. This study also reports on selected results of usability and an electromyographic evaluation of the prototypes against three commercial PC mice (horizontal, slanted, and vertical) by a sample of 20 participants, supporting validation of the development process and the newly developed geometries, with emphasis on the slanted conical innovative shape.