The increased demand for alloys that can serve as implantation devices with outstanding bio-properties has led to the development of numerous biomedical Mg-based alloys. These alloys have been extensively investigated for their performance in living tissue with mixed results. Hence, there are still major concerns regarding the use of magnesium alloys for such applications. Among the issues raised are elevated corrosion rates, hydrogen generation, and the maintenance of mechanical integrity for designated healing times. In addition, toxicity can arise from the addition of alloying elements that are intended to improve the mechanical integrity and corrosion resistance of Mg alloys. The current work reviews the recent advances in the development of Mg alloys for applications as bio-absorbable materials in living organic environments. In particular, it attempts to develop a roadmap of effective factors that can be utilized when designing Mg alloys. Among the factors reviewed are the effects of alloying additions and processing methods on the exhibited mechanical properties and corrosion rates in simulated bio-fluids used in biomedical applications.

Magnesium, Mg, has been widely investigated due to its promising potential as magnesium alloys for various applications, particularly as biomedical implantation devices among other medical applications. This work investigates the influence of different cooling rates on the strength of pure Mg. The cooling rates were set to cover a low cooling rate LCR (0.035 °C/s) in an insulated furnace, a moderate cooling rate MCR (0.074 °C/s) in uninsulated-ends furnace, and a high cooling rate HCR (13.5 °C/s) in liquid CO₂. The casting process was accomplished using a closed system of melting and cooling due to the reactivity-flammability of magnesium in order to minimize processing defects and increase the safety factor. The as-cast samples were metallographically examined for their microstructure, and properties such as impact strength, hardness, and tension were determined. Increasing the solidification rate from 0.035 °C/s to 0.074 °C/s increased the hardness from 30 to 34 Rockwell Hardness and the UTS from 48 to 67 MPa. A higher solidification rate of 13.5 °C/s further enhanced the hardness to 48 Rockwell Hardness and the UTS to 87 MPa in comparison to the 0.074 °C/s cooling rate. Additionally, the fracture behavior and morphology were investigated. It was found that in general, the mechanical properties tended to improve by refining the grain structure.