Araloside A is a pentacyclic triterpenoid saponin, and L‐ascorbic acid is a globally recognized antioxidant. In this study, coadministered araloside A and L‐ascorbic acid were found to have a strong synergistic antioxidant effect, and correlations between cellular antioxidant indexes and free radical scavenging ability were found. Individual and combined pretreatment with araloside A and L‐ascorbic acid increased both cell viability and antioxidant enzyme activity and inhibited the release of lactate dehydrogenase (LDH); the accumulation of malondialdehyde (MDA), lipid peroxidation (LPO) products, and H₂O₂; and the production of intracellular reactive oxygen species (ROS), protein carbonyls, and 8‐hydroxy‐2‐deoxy guanosine (8‐OHdG). Free radical scavenging ability was positively correlated with superoxide dismutase (SOD) and catalase (CAT) activity, the glutathione (GSH)/oxidized glutathione (GSSG) ratio, and total antioxidant capacity (T‐AOC). Our study is the first investigation of araloside A and L‐ascorbic acid coadministration for the treatment of diseases caused by oxidative stress. The synergistic antioxidant effects of araloside A and L‐ascorbic acid support their potential as functional food ingredients for the elimination of oxidative stress‐induced adverse reactions.