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Dr. Chantal Fournier-Wirth
Pathogenesis and Control of Chronic and Emerging Infections- French Blood Establishment
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Academic Career Length
19Years (2008-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications21 December 2016 in Science Translational Medicine
Journal Article
DBDaisy Bougard
Daisy BougardJBJean-Philippe Brandel
Jean-Philippe Brandel
MBMaxime Bélondrade
Maxime Bélondrade
VBVincent Béringue
Vincent Béringue
CSChristiane Segarra
Christiane Segarra
JCJoliette Coste
Joliette Coste +12
A sensitive blood diagnostic assay can identify patients with variant Creutzfeldt-Jakob disease before symptoms appear and during the clinical phase.
1 April 2014 in Biosensors and Bioelectronics
Journal Article
SISarra El Ichi
Sarra El Ichi
FLFanny Leon
Fanny Leon
LVLudivine Vossier
Ludivine Vossier
HMHelene Marchandin
Helene Marchandin
AEAbdelhamid Errachid
Abdelhamid Errachid
CFChantal Fournier-Wirth
Chantal Fournier-Wirth +2
26 February 2020 in mSphere
Journal Article
MBMaxime Bélondrade
Maxime Bélondrade
CJChristelle Jas-Duval
Christelle Jas-Duval
SNSimon Nicot
Simon Nicot
LBLilian Bruyère-Ostells
Lilian Bruyère-Ostells
CMCharly Mayran
Charly Mayran
DBDaisy Bougard
Daisy Bougard +6
Creutzfeldt-Jakob diseases are neurodegenerative disorders for which transmission linked to medical procedures have been reported in hundreds of patients. As prion diseases, they are characterized by an unusual resistance to conventional decontamination processes. Moreover, their large tissue distribution and the ability of prions to attach to many surfaces raised the risk of transmission in health care facilities. It is therefore of major importance that decontamination procedures applied to medical devices before their reprocessing are thoroughly validated for prion inactivation. We previously described an in vitro assay, which allowed us to classify accurately prion decontamination treatments according to their efficacy on variant Creutzfeldt-Jakob disease. The significance of this study is in demonstrating the concordance between previous in vitro results and infectivity studies in transgenic mice. Furthermore, commercial reagents currently used in hospitals were tested by both protocols, and we observed that most of them were ineffective on human prions.
1 July 2018 in Emerging Infectious Diseases
Journal Article
DBDaisy Bougard
Daisy BougardMBMaxime Bélondrade
Maxime Bélondrade
CMCharly Mayran
Charly Mayran
LBLilian Bruyère-Ostells
Lilian Bruyère-Ostells
SLSylvain Lehmann
Sylvain LehmannAGAlison J.E. Green
Alison J.E. Green
+3
A patient with a heterozygous variant of Creutzfeldt-Jakob disease (CJD) with a methionine/valine genotype at codon 129 of the prion protein gene was recently reported. Using an ultrasensitive and specific protein misfolding cyclic amplification-based assay for detecting variant CJD prions in cerebrospinal fluid, we discriminated this heterozygous case of variant CJD from cases of sporadic CJD.
29 May 2018 in Analytical Chemistry
Journal Article
JGJulien Gomez-Martinez
Julien Gomez-Martinez
MSMonique Silvy
Monique Silvy
JCJacques Chiaroni
Jacques Chiaroni
CFChantal Fournier-Wirth
Chantal Fournier-WirthFRFrancis Roubinet
Francis Roubinet
JBJean-Charles Henri Brès
Jean-Charles Henri Brès +1
1 January 2010 in Biologicals
Journal Article
CFChantal Fournier-Wirth
Chantal Fournier-WirthJCJoliette Coste
Joliette Coste
About Me
UMR 1058 PCCEI - Pathogenesis and Control of Chronic and Emerging Infections (University of Montpellier, EFS, Inserm, Université des Antilles - France)
Co-coordinator of “Innovative diagnostic and pathogenesis of emerging infections” research axis
French Blood Establishment (EFS, Montpellier, France)
Regional Scientific Director, EFS Occitanie
Chantal.fournier@efs.sante.fr
Chantal FOURNIER-WIRTH obtained a PhD Degree in Life Sciences, Biochemistry and Molecular Biology at the University of Montpellier (France) in 1999. She started her career as a researcher at the EFS. The team has merged with clinicians in 2015 in a mixed research unit dedicated to the pathogenesis and control of chronic infections directed by Pr Philippe Van de Perre. In the upcoming contract (2021-2026), the integration of researchers and clinicans of the University of the Antilles represents a great opportunity to study emerging infections (UMR PCCEI, 80 members). She is now involved in the development and the coordination of multidisciplinary projects on diagnostic innovations.