Dr. Manel Esteller graduated in Medicine from the Universidad de Barcelona in 1992, where he also obtained his Ph.D. degree specializing in molecular genetics of endometrial carcinoma in 1996. He was an invited researcher at the School of Biological and Medical Sciences at the University of St. Andrews (Scotland, U.K.). From 1997 to 2001, he was a postdoctoral fellow and a research associate at the Johns Hopkins University and School of Medicine (Baltimore, USA), where he studied DNA methylation and human cancer. His work was decisive in establishing promoter hypermethylation of tumor suppressor genes as a common hallmark of all human tumors. From 2008 to 2019, he was the director of the Cancer Epigenetics and Biology Program (PEBC) in Barcelona. He is the director of the Josep Carreras Leukaemia Research Institute (IJC), chairman of Genetics at the School of Medicine of the University of Barcelona, and an ICREA research professor. He is the author of more than 600 original publications in peer-reviewed scientific journals. He is also associate editor for Cancer Research, The Lancet Oncology, Carcinogenesis, Genome Research, and The Journal of The National Cancer Institute. He is the editor-in-chief of Epigenetics. He is also the director of The Cancer Genome Atlas (TCGA) project for Cancer of Unknown Primary (CUP) of the National Cancer Institute-National Institutes of Health (NCI-NIH) in the United States (US).