BACKGROUND:Although puerarin is generally considered as a protective agent for cardio-cerebrovascular diseases, the exact effect on reducing myocardial infarction reperfusion injury (MIRI) is not well understood. This study aimed to pool previous ran...

Feng Liu, Dandan Long, Wenjun Huang, Wanling Peng, Huan Lan, Yafei Zhou, Xitong Dang, Rui Zhou. IJSC 2022;15:247-57. https://doi.org/10.15283/ijsc21148

Pompe disease results from GAA mutations that leads to lysosomal glycogen accumulation and cardiac and skeletal muscle pathology. We have previously generated an infantile-onset Pompe disease patient-derived human-induced pluripotent stem cells (iPSCs) line carrying compound GAA mutations (R608X and E888X). Using his parents' peripheral blood mononuclear cells (PBMCs), we here generated two iPSCs lines which carry mutations of R608X E888X respectively. Both lines show typical cell morphology, high expressed pluripotent and self-renewal markers, normal karyotype, and trilineage differentiation potential. These two lines are valuable re-sources for studying the pathological mechanisms of GAA mutation-caused Pompe disease.

Yuanshu Liu,*, Peng Zhang,*, Wenjun Huang, Feng Liu, Dandan Long, Wanling Peng, Xitong Dang, Xiaorong Zeng, Rui Zhou. IJSC 2021;14:410-22. https://doi.org/10.15283/ijsc21051