The pressure-induced-flow (PIF) processing can effectively prepare high-performance polymer materials. This paper studies the influence of pressure-induced-flow processing on the morphology, thermodynamic and mechanical properties of polypropylene (PP)/polyamide 6 (PA6) blends, PP/polyolefin elastomer (POE) blends and PP/thermoplastic urethane (TPU) blends. The results show that pressure-induced-flow processing can significantly improve the thermodynamic and mechanical properties of the blends by regulating internal structure. Research shows that the pressure-induced-flow processing can increase the strength and the toughness of the blends, particularly in PP/TPU blends.