Air pollutants have significant direct and indirect adverse effects on public health. To explore the relationship between air pollutants and meteorological conditions on the hospitalization for respiratory diseases, we collected a whole year of daily major air pollutants’ concentrations from Shenzhen city in 2013, including Particulate Matter (PM₁₀, PM_2.5), Nitrogen dioxide (NO₂), Ozone (O₃), Sulphur dioxide (SO₂), and Carbon monoxide (CO). Meanwhile, we also gained meteorological data. This study collected 109,927 patients cases with diseases of the respiratory system from 98 hospitals. We investigated the influence of meteorological factors on air pollution by Spearman correlation analysis. Then, we tested the short-term correlation between significant air pollutants and respiratory diseases’ hospitalization by Distributed Lag Non-linear Model (DLNM). There was a significant negative correlation between the north wind and NO₂ and a significant negative correlation between the south wind and six pollutants. Except for CO, other air pollutants were significantly correlated with the number of hospitalized patients during the lag period. Most of the pollutants reached maximum Relative Risk (RR) with a lag of five days. When the time lag was five days, the annual average of PM₁₀, PM_2.5, SO₂, NO₂, and O₃ increased by 10%, and the risk of hospitalization for the respiratory system increased by 0.29%, 0.23%, 0.22%, 0.25%, and 0.22%, respectively. All the pollutants except CO impact the respiratory system’s hospitalization in a short period, and PM10 has the most significant impact. The results are helpful for pollution control from a public health perspective.

Ozone pollution is a prominent public health issue, but there are few studies on the effect of ozone on the ultrastructure of respiratory system; we conducted this research. Exposed to 1.1 ppm O₃ 4 h per day, the mice lungs and bronchi were taken on the 15th or 30th day. The sections stained with HE and immunohistochemical streptavidin–peroxidase methods for NQO1, Nrf2, and Keap1 were observed and measured under the optical microscope. TEM was used for ultrastructure observation. The animals’ serums were detected for CRP and IL-6 levels. The HE-stained sections showed no obvious micromorphological changes in the O₃ exposure, but the NQO1 average optical density was higher than the control on the 15th day (p < 0.05). The ultrastructural changes were found in the O₃ exposure group, such as bulges and vacuoles in type I alveolar cells, the increased evacuation of substance from lamellar bodies in the type II alveolar cells, the increased space around the goblet nucleus, binuclear goblet, and columnar cells. CRP and IL-6 levels increased compared with the control (p < 0.05). Although inhaling 1.1 ppm O₃ had no significant effect on the micromorphology of the mice lungs and bronchi, it did affect the ultrastructure with oxidative stress and inflammatory responses.