The METAPOLIS as the polycentric network of urban–rural settlement is undergoing constant transformation and urbanization processes. In particular, the associated imbalance of the shrinkage and growth of different settlement types in relative geographical proximity causes negative effects, such as urban sprawl and the divergence of urban–rural lifestyles with their related resource, land and energy consumption. Implicitly related to these developments, national and global sustainable development goals for the building sector lead to the question of how a region can be assessed without detailed research and surveys to identify critical areas with high potential for sustainable development. In this study, the TOPOI method is used. It classifies settlement units and their interconnections along the urban–rural gradient, in order to quantify and assess the land-uptake and global warming potential driven by residential developments. Applying standard planning parameters in combination with key data from a comprehensive life cycle assessment of the residential building stock, a detailed understanding of different settlement types and their associated resource and energy consumption is achieved.