Zlatko Fras

Prof. Zlatko Fras

Medical Faculty, University of Ljubljana, Ljubljana, Slovenia
orcid

Research Focus & Metrics

Academic Career Length

28Years (1999-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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31 August 2019 in European Heart Journal
Verified
Journal Article
Open access
PDF file
FCFrancesco Cosentino
Francesco Cosentino
PGPeter J Grant
Peter J Grant
VAVictor Aboyans
Victor Aboyans
CBClifford J Bailey
Clifford J Bailey
ACAntonio Ceriello
Antonio Ceriello
TCTahseen Ahmad Chowdhury
Tahseen Ahmad Chowdhury
Abbreviations and acronyms:2hPG2 h plasma glucoseABIAnkle–brachial indexABPMAmbulatory blood pressure monitoringACCORDAction to Control Cardiovascular Risk in D

3 May 2012 in European Heart Journal
Verified
Journal Article
Open access
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JPJoep Perk
Joep Perk
GBGuy De Backer
Guy De Backer
HGHelmut Gohlke
Helmut Gohlke
IGIan Graham
Ian Graham
ŽRŽeljko Reiner
Željko Reiner
DRDocument Reviewers
Document Reviewers
Atherosclerotic cardiovascular disease (CVD) is a chronic disorder developing insidiously throughout life and usually progressing to an advanced stage by the time symptoms occur. It remains the major cause of premature death in Europe, even though CVD mortality has fallen considerably over recent decades in many European countries. It is estimated that >80% of all CVD mortality now occurs in developing countries.

26 August 2017 in European Heart Journal
Verified
Journal Article
Open access
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VAVictor Aboyans
Victor Aboyans
Jean-Baptiste RiccoJean-Baptiste Ricco
Jean-Baptiste Ricco
MBMarie-Louise E L Bartelink
Marie-Louise E L Bartelink
MBMartin Björck
Martin Björck
MBMarianne Brodmann
Marianne Brodmann
AOAgu Obiekezie
Agu Obiekezie
The disclosure forms of all experts involved in the development of these guidelines are available on the ESC website http://www.escardio.org/guidelines.

26 August 2017 in European Heart Journal
Verified
Journal Article
Open access
PDF file
MVMarco Valgimigli
Marco Valgimigli
HBHéctor Bueno
Héctor Bueno
RBRobert A Byrne
Robert A Byrne
JCJean-Philippe Collet
Jean-Philippe Collet
FCFrancesco Costa
Francesco Costa
TKTim Kinnaird
Tim Kinnaird
The disclosure forms of all experts involved in the development of this focused update are available on the ESC website http://www.escardio.org/guidelines.

10 December 2019 in European Heart Journal
Verified
Journal Article
Open access
ATAdam Timmis
Adam Timmis
NTNick Townsend
Nick Townsend
CGChris P Gale
Chris P Gale
ATAleksandra Torbica
Aleksandra Torbica
MLMaddalena Lettino
Maddalena Lettino
IBIsabel Bardinet
Isabel Bardinet
Aims: The 2019 report from the European Society of Cardiology (ESC) Atlas provides a contemporary analysis of cardiovascular disease (CVD) statistics across 56 member countries, with particular emphasis on international inequalities in disease burden and healthcare delivery together with estimates of progress towards meeting 2025 World Health Organization (WHO) non-communicable disease targets. Methods and results: In this report, contemporary CVD statistics are presented for member countries of the ESC. The statistics are drawn from the ESC Atlas which is a repository of CVD data from a variety of sources including the WHO, the Institute for Health Metrics and Evaluation, and the World Bank. The Atlas also includes novel ESC sponsored data on human and capital infrastructure and cardiovascular healthcare delivery obtained by annual survey of the national societies of ESC member countries. Across ESC member countries, the prevalence of obesity (body mass index ≥30 kg/m2) and diabetes has increased two- to three-fold during the last 30 years making the WHO 2025 target to halt rises in these risk factors unlikely to be achieved. More encouraging have been variable declines in hypertension, smoking, and alcohol consumption but on current trends only the reduction in smoking from 28% to 21% during the last 20 years appears sufficient for the WHO target to be achieved. The median age-standardized prevalence of major risk factors was higher in middle-income compared with high-income ESC member countries for hypertension {23.8% [interquartile range (IQR) 22.5–23.1%] vs. 15.7% (IQR 14.5–21.1%)}, diabetes [7.7% (IQR 7.1–10.1%) vs. 5.6% (IQR 4.8–7.0%)], and among males smoking [43.8% (IQR 37.4–48.0%) vs. 26.0% (IQR 20.9–31.7%)] although among females smoking was less common in middle-income countries [8.7% (IQR 3.0–10.8) vs. 16.7% (IQR 13.9–19.7%)]. There were associated inequalities in disease burden with disability-adjusted life years per 100 000 people due to CVD over three times as high in middle-income [7160 (IQR 5655–8115)] compared with high-income [2235 (IQR 1896–3602)] countries. Cardiovascular disease mortality was also higher in middle-income countries where it accounted for a greater proportion of potential years of life lost compared with high-income countries in both females (43% vs. 28%) and males (39% vs. 28%). Despite the inequalities in disease burden across ESC member countries, survey data from the National Cardiac Societies of the ESC showed that middle-income member countries remain severely under-resourced compared with high-income countries in terms of cardiological person-power and technological infrastructure. Under-resourcing in middle-income countries is associated with a severe procedural deficit compared with high-income countries in terms of coronary intervention, device implantation and cardiac surgical procedures. Conclusion: A seemingly inexorable rise in the prevalence of obesity and diabetes currently provides the greatest challenge to achieving further reductions in CVD burden across ESC member countries. Additional challenges are provided by inequalities in disease burden that now require intensification of policy initiatives in order to reduce population risk and prioritize cardiovascular healthcare delivery, particularly in the middle-income countries of the ESC where need is greatest.

10 February 2019 in European Journal of Preventive Cardiology
Verified
Journal Article
Open access
KKKornelia P. Kotseva
Kornelia P. Kotseva
GBGuy De Backer
Guy De Backer
DBDirk De Bacquer
Dirk De Bacquer
LRLars Rydén
Lars Rydén
AHArno Hoes
Arno Hoes
OIon behalf of the EUROASPIRE Investigators*
on behalf of the EUROASPIRE Investigators*
Aims: The aim of this study was to determine whether the Joint European Societies guidelines on secondary cardiovascular prevention are followed in everyday practice. Design: A cross-sectional ESC-EORP survey (EUROASPIRE V) at 131 centres in 81 regions in 27 countries. Methods: Patients (<80 years old) with verified coronary artery events or interventions were interviewed and examined ≥6 months later. Results: A total of 8261 patients (females 26%) were interviewed. Nineteen per cent smoked and 55% of them were persistent smokers, 38% were obese (body mass index ≥30 kg/m2), 59% were centrally obese (waist circumference: men ≥102 cm; women ≥88 cm) while 66% were physically active <30 min 5 times/week. Forty-two per cent had a blood pressure ≥140/90 mmHg (≥140/85 if diabetic), 71% had low-density lipoprotein cholesterol ≥1.8 mmol/L (≥70 mg/dL) and 29% reported having diabetes. Cardioprotective medication was: anti-platelets 93%, beta-blockers 81%, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers 75% and statins 80%. Conclusion: A large majority of coronary patients have unhealthy lifestyles in terms of smoking, diet and sedentary behaviour, which adversely impacts major cardiovascular risk factors. A majority did not achieve their blood pressure, low-density lipoprotein cholesterol and glucose targets. Cardiovascular prevention requires modern preventive cardiology programmes delivered by interdisciplinary teams of healthcare professionals addressing all aspects of lifestyle and risk factor management, in order to reduce the risk of recurrent cardiovascular events.