It has been confirmed that diabetes mellitus (DM) carries increased oxidative stress. This study evaluated the effects of salidroside from Rhodiolae Radix on diabetes-induced oxidative stress in mice. After induction of diabetes, diabetic mice were administered daily doses of 50, 100 and 200 mg/kg salidroside for 28 days. Body weights, fasting blood glucose (FBG), serum insulin, TC (total cholesterol), TG (triglyceride), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were measured. Results showed that salidroside possessed hypoglycemic activity and protective effects against diabetes-induced oxidative stress, which could significantly reduce FBG, TC, TG and MDA levels, and at same time increase serum insulin levels, SOD, GPx and CAT activities. Therefore, salidroside should be considered as a candidate for future studies on diabetes.

Fatigue properties are important parameters for the safety design and security evaluation of pipelines. In this work, fatigue life and fatigue crack propagation of full-thickness X80 pipeline steel joints compared with the base metal (BM) was investigated. Full-thickness BM specimens showed superior fatigue life compared with that of welded joints. The fatigue crack initiation of full-thickness X80 welded joint specimens occurred at the outside weld toe and then grew inward until a fracture was formed. During fatigue crack growth in the heat-affected zone (HAZ), crack growth rate linearly increased with increased ΔK in each HAZ subregion. However, the change rate of fatigue crack growth rate (da/dN) differed among HAZ subregions. This difference was related to the variation in crack path and fracture mode because of the possible microstructural sensitivity of fatigue crack propagation behaviour.