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Dr. Van-Mai Cao-Lormeau
Institut Louis Malardé, Po Box 30, 98 713 Papeete, Tahiti, French Polynesia, France

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Research Keywords & Expertise

0 Epidemiology
0 Molecular Epidemiology
0 Surveillance
0 Pathogenesis and prevalence of mosquito-borne viruses
0 Particularly dengue

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Surveillance
Epidemiology
Zika and chikungunya

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Short Biography

Van-Mai Cao-Lormeau, PhD, is the Director of the Laboratory of research on Infectious Vector-borne diseases (LIV) at the Institut Louis Malardé (ILM), French Polynesia. She has been the principal investigator of many research projects interested in the surveillance, epidemiology, molecular epidemiology, pathogenesis and prevalence of arboviruses, particularly dengue, Zika and chikungunya in the Pacific islands.

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Correspondence
Published: 31 May 2021 in Travel Medicine and Infectious Disease
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ACS Style

Van-Mai Cao-Lormeau; Iotefa Teiti; Anita Teissier; Vaea Richard; Maite Aubry. Self-sampling kit delivered to travelers for COVID-19 testing 4 days after arrival in French Polynesia, July 2020-February 2021. Travel Medicine and Infectious Disease 2021, 43, 102098 .

AMA Style

Van-Mai Cao-Lormeau, Iotefa Teiti, Anita Teissier, Vaea Richard, Maite Aubry. Self-sampling kit delivered to travelers for COVID-19 testing 4 days after arrival in French Polynesia, July 2020-February 2021. Travel Medicine and Infectious Disease. 2021; 43 ():102098.

Chicago/Turabian Style

Van-Mai Cao-Lormeau; Iotefa Teiti; Anita Teissier; Vaea Richard; Maite Aubry. 2021. "Self-sampling kit delivered to travelers for COVID-19 testing 4 days after arrival in French Polynesia, July 2020-February 2021." Travel Medicine and Infectious Disease 43, no. : 102098.

Journal article
Published: 15 March 2021 in Nature Communications
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Zika virus (ZIKV) has caused large, brief outbreaks in isolated populations, however ZIKV can also persist at low levels over multiple years. The reasons for these diverse transmission dynamics remain poorly understood. In Fiji, which has experienced multiple large single-season dengue epidemics, there was evidence of multi-year transmission of ZIKV between 2013 and 2017. To identify factors that could explain these differences in dynamics between closely related mosquito-borne flaviviruses, we jointly fit a transmission dynamic model to surveillance, serological and molecular data. We estimate that the observed dynamics of ZIKV were the result of two key factors: strong seasonal effects, which created an ecologically optimal time of year for outbreaks; and introduction of ZIKV after this optimal time, which allowed ZIKV transmission to persist over multiple seasons. The ability to jointly fit to multiple data sources could help identify a similar range of possible outbreak dynamics in other settings.

ACS Style

Alasdair D. Henderson; Mike Kama; Maite Aubry; Stephane Hue; Anita Teissier; Taina Naivalu; Vinaisi D. Bechu; Jimaima Kailawadoko; Isireli Rabukawaqa; Aalisha Sahukhan; Martin L. Hibberd; Eric J. Nilles; Sebastian Funk; Jimmy Whitworth; Conall H. Watson; Colleen L. Lau; W. John Edmunds; Van-Mai Cao-Lormeau; Adam J. Kucharski. Interactions between timing and transmissibility explain diverse flavivirus dynamics in Fiji. Nature Communications 2021, 12, 1 -9.

AMA Style

Alasdair D. Henderson, Mike Kama, Maite Aubry, Stephane Hue, Anita Teissier, Taina Naivalu, Vinaisi D. Bechu, Jimaima Kailawadoko, Isireli Rabukawaqa, Aalisha Sahukhan, Martin L. Hibberd, Eric J. Nilles, Sebastian Funk, Jimmy Whitworth, Conall H. Watson, Colleen L. Lau, W. John Edmunds, Van-Mai Cao-Lormeau, Adam J. Kucharski. Interactions between timing and transmissibility explain diverse flavivirus dynamics in Fiji. Nature Communications. 2021; 12 (1):1-9.

Chicago/Turabian Style

Alasdair D. Henderson; Mike Kama; Maite Aubry; Stephane Hue; Anita Teissier; Taina Naivalu; Vinaisi D. Bechu; Jimaima Kailawadoko; Isireli Rabukawaqa; Aalisha Sahukhan; Martin L. Hibberd; Eric J. Nilles; Sebastian Funk; Jimmy Whitworth; Conall H. Watson; Colleen L. Lau; W. John Edmunds; Van-Mai Cao-Lormeau; Adam J. Kucharski. 2021. "Interactions between timing and transmissibility explain diverse flavivirus dynamics in Fiji." Nature Communications 12, no. 1: 1-9.

Journal article
Published: 10 February 2021 in Nature Communications
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The global emergence of Zika virus (ZIKV) revealed the unprecedented ability for a mosquito-borne virus to cause congenital birth defects. A puzzling aspect of ZIKV emergence is that all human outbreaks and birth defects to date have been exclusively associated with the Asian ZIKV lineage, despite a growing body of laboratory evidence pointing towards higher transmissibility and pathogenicity of the African ZIKV lineage. Whether this apparent paradox reflects the use of relatively old African ZIKV strains in most laboratory studies is unclear. Here, we experimentally compare seven low-passage ZIKV strains representing the recently circulating viral genetic diversity. We find that recent African ZIKV strains display higher transmissibility in mosquitoes and higher lethality in both adult and fetal mice than their Asian counterparts. We emphasize the high epidemic potential of African ZIKV strains and suggest that they could more easily go unnoticed by public health surveillance systems than Asian strains due to their propensity to cause fetal loss rather than birth defects.

ACS Style

Fabien Aubry; Sofie Jacobs; Maïlis Darmuzey; Sebastian Lequime; Leen Delang; Albin Fontaine; Natapong Jupatanakul; Elliott F. Miot; Stéphanie Dabo; Caroline Manet; Xavier Montagutelli; Artem Baidaliuk; Fabiana Gámbaro; Etienne Simon-Lorière; Maxime Gilsoul; Claudia M. Romero-Vivas; Van-Mai Cao-Lormeau; Richard G. Jarman; Cheikh T. Diagne; Oumar Faye; Ousmane Faye; Amadou A. Sall; Johan Neyts; Laurent Nguyen; Suzanne J. F. Kaptein; Louis Lambrechts. Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains. Nature Communications 2021, 12, 1 -14.

AMA Style

Fabien Aubry, Sofie Jacobs, Maïlis Darmuzey, Sebastian Lequime, Leen Delang, Albin Fontaine, Natapong Jupatanakul, Elliott F. Miot, Stéphanie Dabo, Caroline Manet, Xavier Montagutelli, Artem Baidaliuk, Fabiana Gámbaro, Etienne Simon-Lorière, Maxime Gilsoul, Claudia M. Romero-Vivas, Van-Mai Cao-Lormeau, Richard G. Jarman, Cheikh T. Diagne, Oumar Faye, Ousmane Faye, Amadou A. Sall, Johan Neyts, Laurent Nguyen, Suzanne J. F. Kaptein, Louis Lambrechts. Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains. Nature Communications. 2021; 12 (1):1-14.

Chicago/Turabian Style

Fabien Aubry; Sofie Jacobs; Maïlis Darmuzey; Sebastian Lequime; Leen Delang; Albin Fontaine; Natapong Jupatanakul; Elliott F. Miot; Stéphanie Dabo; Caroline Manet; Xavier Montagutelli; Artem Baidaliuk; Fabiana Gámbaro; Etienne Simon-Lorière; Maxime Gilsoul; Claudia M. Romero-Vivas; Van-Mai Cao-Lormeau; Richard G. Jarman; Cheikh T. Diagne; Oumar Faye; Ousmane Faye; Amadou A. Sall; Johan Neyts; Laurent Nguyen; Suzanne J. F. Kaptein; Louis Lambrechts. 2021. "Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains." Nature Communications 12, no. 1: 1-14.

Report
Published: 19 November 2020 in Science
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The drivers and patterns of zoonotic virus emergence in the human population are poorly understood. The mosquito Aedes aegypti is a major arbovirus vector native to Africa that invaded most of the world’s tropical belt over the past four centuries, after the evolution of a “domestic” form that specialized in biting humans and breeding in water storage containers. Here, we show that human specialization and subsequent spread of A. aegypti out of Africa were accompanied by an increase in its intrinsic ability to acquire and transmit the emerging human pathogen Zika virus. Thus, the recent evolution and global expansion of A. aegypti promoted arbovirus emergence not solely through increased vector–host contact but also as a result of enhanced vector susceptibility.

ACS Style

Fabien Aubry; Stéphanie Dabo; Caroline Manet; Igor Filipović; Noah H. Rose; Elliott F. Miot; Daria Martynow; Artem Baidaliuk; Sarah H. Merkling; Laura B. Dickson; Anna B. Crist; Victor O. Anyango; Claudia M. Romero-Vivas; Anubis Vega-Rúa; Isabelle Dusfour; Davy Jiolle; Christophe Paupy; Martin N. Mayanja; Julius J. Lutwama; Alain Kohl; Veasna Duong; Alongkot Ponlawat; Massamba Sylla; Jewelna Akorli; Sampson Otoo; Joel Lutomiah; Rosemary Sang; John-Paul Mutebi; Van-Mai Cao-Lormeau; Richard G. Jarman; Cheikh T. Diagne; Oumar Faye; Ousmane Faye; Amadou A. Sall; Carolyn S. McBride; Xavier Montagutelli; Gordana Rašić; Louis Lambrechts. Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations. Science 2020, 370, 991 -996.

AMA Style

Fabien Aubry, Stéphanie Dabo, Caroline Manet, Igor Filipović, Noah H. Rose, Elliott F. Miot, Daria Martynow, Artem Baidaliuk, Sarah H. Merkling, Laura B. Dickson, Anna B. Crist, Victor O. Anyango, Claudia M. Romero-Vivas, Anubis Vega-Rúa, Isabelle Dusfour, Davy Jiolle, Christophe Paupy, Martin N. Mayanja, Julius J. Lutwama, Alain Kohl, Veasna Duong, Alongkot Ponlawat, Massamba Sylla, Jewelna Akorli, Sampson Otoo, Joel Lutomiah, Rosemary Sang, John-Paul Mutebi, Van-Mai Cao-Lormeau, Richard G. Jarman, Cheikh T. Diagne, Oumar Faye, Ousmane Faye, Amadou A. Sall, Carolyn S. McBride, Xavier Montagutelli, Gordana Rašić, Louis Lambrechts. Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations. Science. 2020; 370 (6519):991-996.

Chicago/Turabian Style

Fabien Aubry; Stéphanie Dabo; Caroline Manet; Igor Filipović; Noah H. Rose; Elliott F. Miot; Daria Martynow; Artem Baidaliuk; Sarah H. Merkling; Laura B. Dickson; Anna B. Crist; Victor O. Anyango; Claudia M. Romero-Vivas; Anubis Vega-Rúa; Isabelle Dusfour; Davy Jiolle; Christophe Paupy; Martin N. Mayanja; Julius J. Lutwama; Alain Kohl; Veasna Duong; Alongkot Ponlawat; Massamba Sylla; Jewelna Akorli; Sampson Otoo; Joel Lutomiah; Rosemary Sang; John-Paul Mutebi; Van-Mai Cao-Lormeau; Richard G. Jarman; Cheikh T. Diagne; Oumar Faye; Ousmane Faye; Amadou A. Sall; Carolyn S. McBride; Xavier Montagutelli; Gordana Rašić; Louis Lambrechts. 2020. "Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations." Science 370, no. 6519: 991-996.

Preprint content
Published: 01 September 2020
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SummaryThe global emergence of Zika virus (ZIKV) in the last decade revealed the unprecedented ability for a mosquito-borne virus to cause congenital birth defects such as microcephaly. A puzzling aspect of ZIKV emergence is that all human outbreaks and birth defects to date have been exclusively associated with the Asian ZIKV lineage, despite a growing body of laboratory evidence pointing towards higher transmissibility and pathogenicity of the African ZIKV lineage. Whether this apparent paradox reflects the use of relatively old African ZIKV strains in most laboratory studies is unclear. Here, we experimentally compared the transmissibility and pathogenicity of seven low-passage ZIKV strains representing the recently circulating viral genetic diversity. We found that recent African ZIKV strains largely outperformed their Asian counterparts in mosquito transmission kinetics experiments, which translated into a markedly higher epidemic potential in outbreak computer simulations. In addition, African ZIKV strains were significantly more lethal than Asian ZIKV strains in immunocompromised adult mice. Finally, prenatal infection of immunocompetent mouse embryos with an African ZIKV strain resulted in embryonic death whereas it caused microcephaly with Asian ZIKV strains. Together, our results demonstrate the high epidemic potential and pathogenicity of recent ZIKV strains from Africa. Importantly, they also imply that the African ZIKV lineage could more easily go unnoticed by public health surveillance systems than the Asian ZIKV lineage due to its propensity to cause fetal loss rather than birth defects.

ACS Style

Fabien Aubry; Sofie Jacobs; Maïlis Darmuzey; Sebastian Lequime; Leen Delang; Albin Fontaine; Natapong Jupatanakul; Elliott F. Miot; Stéphanie Dabo; Caroline Manet; Xavier Montagutelli; Artem Baidaliuk; Fabiana Gambaro; Etienne Simon-Lorière; Maxime Gilsoul; Claudia M. Romero-Vivas; Van-Mai Cao-Lormeau; Richard G. Jarman; Cheikh T. Diagne; Oumar Faye; Ousmane Faye; Amadou A. Sall; Johan Neyts; Laurent Nguyen; Suzanne J. F. Kaptein; Louis Lambrechts. High transmissibility and fetal pathogenicity of recent Zika virus strains from the African lineage. 2020, 1 .

AMA Style

Fabien Aubry, Sofie Jacobs, Maïlis Darmuzey, Sebastian Lequime, Leen Delang, Albin Fontaine, Natapong Jupatanakul, Elliott F. Miot, Stéphanie Dabo, Caroline Manet, Xavier Montagutelli, Artem Baidaliuk, Fabiana Gambaro, Etienne Simon-Lorière, Maxime Gilsoul, Claudia M. Romero-Vivas, Van-Mai Cao-Lormeau, Richard G. Jarman, Cheikh T. Diagne, Oumar Faye, Ousmane Faye, Amadou A. Sall, Johan Neyts, Laurent Nguyen, Suzanne J. F. Kaptein, Louis Lambrechts. High transmissibility and fetal pathogenicity of recent Zika virus strains from the African lineage. . 2020; ():1.

Chicago/Turabian Style

Fabien Aubry; Sofie Jacobs; Maïlis Darmuzey; Sebastian Lequime; Leen Delang; Albin Fontaine; Natapong Jupatanakul; Elliott F. Miot; Stéphanie Dabo; Caroline Manet; Xavier Montagutelli; Artem Baidaliuk; Fabiana Gambaro; Etienne Simon-Lorière; Maxime Gilsoul; Claudia M. Romero-Vivas; Van-Mai Cao-Lormeau; Richard G. Jarman; Cheikh T. Diagne; Oumar Faye; Ousmane Faye; Amadou A. Sall; Johan Neyts; Laurent Nguyen; Suzanne J. F. Kaptein; Louis Lambrechts. 2020. "High transmissibility and fetal pathogenicity of recent Zika virus strains from the African lineage." , no. : 1.

Journal article
Published: 01 July 2020 in International Journal of Infectious Diseases
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Ross River virus (RRV) is a zoonotic alphavirus transmitted by several mosquito species. Until recently, endemic transmission was only considered possible in the presence of marsupial reservoirs. We investigated RRV seroprevalence in placental mammals, including horses, cows, goats, pigs, dogs, rats, and mice in Fiji, where there are no marsupials. A total of 302 vertebrate serum samples were collected from 86 households from 10 communities in Western Fiji. Neutralizing antibodies against RRV were detected in 28 to 100% of sera depending on species, and neutralization was strong even at high dilutions. Our results are unlikely to be due to cross reactions; Chikungunya is the only other alphavirus known to be present in the Pacific Islands, but it rarely spills over into non-humans, even during epidemics. Our findings, together with recent report of high RRV seroprevalence in humans, strongly suggest that RRV is circulating in Fiji in the absence of marsupial reservoirs. Considering that all non-human vertebrates present in Fiji are panglobal in distribution, RRV has the potential to further expand its geographic range. Further surveillance and access to diagnostics of RRV is critical for the early detection of emergence and outbreaks.

ACS Style

Eri Togami; Narayan Gyawali; Oselyne Ong; Mike Kama; Van-Mai Cao-Lormeau; Maite Aubry; Albert Ko; Eric J. Nilles; Julie M. Collins-Emerson; Gregor Devine; Philip Weinstein; Colleen L. Lau. First evidence of concurrent enzootic and endemic transmission of Ross River virus in the absence of marsupial reservoirs in Fiji. International Journal of Infectious Diseases 2020, 96, 94 -96.

AMA Style

Eri Togami, Narayan Gyawali, Oselyne Ong, Mike Kama, Van-Mai Cao-Lormeau, Maite Aubry, Albert Ko, Eric J. Nilles, Julie M. Collins-Emerson, Gregor Devine, Philip Weinstein, Colleen L. Lau. First evidence of concurrent enzootic and endemic transmission of Ross River virus in the absence of marsupial reservoirs in Fiji. International Journal of Infectious Diseases. 2020; 96 ():94-96.

Chicago/Turabian Style

Eri Togami; Narayan Gyawali; Oselyne Ong; Mike Kama; Van-Mai Cao-Lormeau; Maite Aubry; Albert Ko; Eric J. Nilles; Julie M. Collins-Emerson; Gregor Devine; Philip Weinstein; Colleen L. Lau. 2020. "First evidence of concurrent enzootic and endemic transmission of Ross River virus in the absence of marsupial reservoirs in Fiji." International Journal of Infectious Diseases 96, no. : 94-96.

Research article
Published: 06 March 2020 in PLOS Neglected Tropical Diseases
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Understanding the transition of epidemic to endemic dengue transmission remains a challenge in regions where serotypes co-circulate and there is extensive human mobility. French Polynesia, an isolated group of 117 islands of which 72 are inhabited, distributed among five geographically separated subdivisions, has recorded mono-serotype epidemics since 1944, with long inter-epidemic periods of circulation. Laboratory confirmed cases have been recorded since 1978, enabling exploration of dengue epidemiology under monotypic conditions in an isolated, spatially structured geographical location. A database was constructed of confirmed dengue cases, geolocated to island for a 35-year period. Statistical analyses of viral establishment, persistence and fade-out as well as synchrony among subdivisions were performed. Seven monotypic and one heterotypic dengue epidemic occurred, followed by low-level viral circulation with a recrudescent epidemic occurring on one occasion. Incidence was asynchronous among the subdivisions. Complete viral die-out occurred on several occasions with invasion of a new serotype. Competitive serotype replacement has been observed previously and seems to be characteristic of the South Pacific. Island population size had a strong impact on the establishment, persistence and fade-out of dengue cases and endemicity was estimated achievable only at a population size in excess of 175 000. Despite island remoteness and low population size, dengue cases were observed somewhere in French Polynesia almost constantly, in part due to the spatial structuration generating asynchrony among subdivisions. Long-term persistence of dengue virus in this group of island populations may be enabled by island hopping, although could equally be explained by a reservoir of sub-clinical infections on the most populated island, Tahiti.

ACS Style

Yoann Teissier; Richard Paul; Maite Aubry; Xavier Rodo; Carlos Dommar; Henrik Salje; Anavaj Sakuntabhai; Bernard Cazelles; Van-Mai Cao-Lormeau. Long-term persistence of monotypic dengue transmission in small size isolated populations, French Polynesia, 1978-2014. PLOS Neglected Tropical Diseases 2020, 14, e0008110 .

AMA Style

Yoann Teissier, Richard Paul, Maite Aubry, Xavier Rodo, Carlos Dommar, Henrik Salje, Anavaj Sakuntabhai, Bernard Cazelles, Van-Mai Cao-Lormeau. Long-term persistence of monotypic dengue transmission in small size isolated populations, French Polynesia, 1978-2014. PLOS Neglected Tropical Diseases. 2020; 14 (3):e0008110.

Chicago/Turabian Style

Yoann Teissier; Richard Paul; Maite Aubry; Xavier Rodo; Carlos Dommar; Henrik Salje; Anavaj Sakuntabhai; Bernard Cazelles; Van-Mai Cao-Lormeau. 2020. "Long-term persistence of monotypic dengue transmission in small size isolated populations, French Polynesia, 1978-2014." PLOS Neglected Tropical Diseases 14, no. 3: e0008110.

Journal article
Published: 28 January 2020 in eLife
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It has been commonly assumed that Zika virus (ZIKV) infection confers long-term protection against reinfection, preventing ZIKV from re-emerging in previously affected areas for several years. However, the long-term immune response to ZIKV following an outbreak remains poorly documented. We compared results from eight serological surveys before and after known ZIKV outbreaks in French Polynesia and Fiji, including cross-sectional and longitudinal studies. We found evidence of a decline in seroprevalence in both countries over a two-year period following first reported ZIKV transmission. This decline was concentrated in adults, while high seroprevalence persisted in children. In the Fiji cohort, there was also a significant decline in neutralizing antibody titres against ZIKV, but not against dengue viruses that circulated during the same period.

ACS Style

Alasdair D Henderson; Maite Aubry; Mike Kama; Jessica Vanhomwegen; Anita Teissier; Teheipuaura Mariteragi-Helle; Tuterarii Paoaafaite; Yoann Teissier; Jean-Claude Manuguerra; John Edmunds; Jimmy Whitworth; Conall H Watson; Colleen L Lau; Van-Mai Cao-Lormeau; Adam J Kucharski. Zika seroprevalence declines and neutralizing antibodies wane in adults following outbreaks in French Polynesia and Fiji. eLife 2020, 9, 1 .

AMA Style

Alasdair D Henderson, Maite Aubry, Mike Kama, Jessica Vanhomwegen, Anita Teissier, Teheipuaura Mariteragi-Helle, Tuterarii Paoaafaite, Yoann Teissier, Jean-Claude Manuguerra, John Edmunds, Jimmy Whitworth, Conall H Watson, Colleen L Lau, Van-Mai Cao-Lormeau, Adam J Kucharski. Zika seroprevalence declines and neutralizing antibodies wane in adults following outbreaks in French Polynesia and Fiji. eLife. 2020; 9 ():1.

Chicago/Turabian Style

Alasdair D Henderson; Maite Aubry; Mike Kama; Jessica Vanhomwegen; Anita Teissier; Teheipuaura Mariteragi-Helle; Tuterarii Paoaafaite; Yoann Teissier; Jean-Claude Manuguerra; John Edmunds; Jimmy Whitworth; Conall H Watson; Colleen L Lau; Van-Mai Cao-Lormeau; Adam J Kucharski. 2020. "Zika seroprevalence declines and neutralizing antibodies wane in adults following outbreaks in French Polynesia and Fiji." eLife 9, no. : 1.

Journal article
Published: 02 November 2019 in International Journal of Infectious Diseases
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Objectives In Fiji, autochthonous chikungunya virus (CHIKV) infection was first detected in March 2015. In a previous serosurvey conducted during October–November 2015, we reported a prevalence of anti-CHIKV IgG antibodies of 0.9%. In the present study, we investigated the seroprevalence of CHIKV two years after its emergence in Fiji. Methods Sera from 320 residents of Fiji recruited in June 2017, from the same cohort of individuals that participated in the serosurvey in 2015, were tested for the presence of IgG antibodies against CHIKV using a recombinant antigen-based microsphere immunoassay. Results Between 2015 and 2017, CHIKV seroprevalence among residents increased from 0.9% (3/333) to 12.8% (41/320). Of the participants with available serum samples collected in both 2015 and 2017 (n=200), 31 (15.5%) who were seronegative in 2015 had seroconverted to CHIKV in 2017. Conclusions Our findings suggest that low-level transmission of CHIKV occurred during the two years following the emergence of the virus in Fiji. No CHIKV infection has been reported in Fiji since 2017, but due to the presumed low herd immunity of the population, the risk of CHIKV re-emergence is high. Consequently, chikungunya should be considered in the differential diagnosis of acute febrile diseases in Fiji.

ACS Style

Maite Aubry; Mike Kama; Alasdair D. Henderson; Anita Teissier; Jessica Vanhomwegen; Teheipuaura Mariteragi-Helle; Tuterarii Paoaafaite; Jean-Claude Manuguerra; Ketan Christi; Conall H. Watson; Colleen L. Lau; Adam J. Kucharski; Van-Mai Cao-Lormeau. Low chikungunya virus seroprevalence two years after emergence in Fiji. International Journal of Infectious Diseases 2019, 90, 223 -225.

AMA Style

Maite Aubry, Mike Kama, Alasdair D. Henderson, Anita Teissier, Jessica Vanhomwegen, Teheipuaura Mariteragi-Helle, Tuterarii Paoaafaite, Jean-Claude Manuguerra, Ketan Christi, Conall H. Watson, Colleen L. Lau, Adam J. Kucharski, Van-Mai Cao-Lormeau. Low chikungunya virus seroprevalence two years after emergence in Fiji. International Journal of Infectious Diseases. 2019; 90 ():223-225.

Chicago/Turabian Style

Maite Aubry; Mike Kama; Alasdair D. Henderson; Anita Teissier; Jessica Vanhomwegen; Teheipuaura Mariteragi-Helle; Tuterarii Paoaafaite; Jean-Claude Manuguerra; Ketan Christi; Conall H. Watson; Colleen L. Lau; Adam J. Kucharski; Van-Mai Cao-Lormeau. 2019. "Low chikungunya virus seroprevalence two years after emergence in Fiji." International Journal of Infectious Diseases 90, no. : 223-225.

Journal article
Published: 15 September 2019 in Journal of Virology
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The mosquito Aedes aegypti carries several arthropod-borne viruses (arboviruses) that are pathogenic to humans, including dengue and Zika viruses. Interestingly, A. aegypti is also naturally infected with insect-only viruses, such as cell-fusing agent virus. Although interactions between cell-fusing agent virus and dengue virus have been documented in mosquito cells in culture, whether wild strains of cell-fusing agent virus interfere with arbovirus transmission by live mosquitoes was unknown. We used an experimental approach to demonstrate that cell-fusing agent virus infection reduces the propagation of dengue and Zika viruses in A. aegypti mosquitoes. These results support the idea that insect-only viruses in nature can modulate the ability of mosquitoes to carry arboviruses of medical significance and that they could possibly be manipulated to reduce arbovirus transmission.

ACS Style

Artem Baidaliuk; Elliott Miot; Sebastian Lequime; Isabelle Moltini-Conclois; Fanny Delaigue; Stéphanie Dabo; Laura B. Dickson; Fabien Aubry; Sarah H. Merkling; Van-Mai Cao-Lormeau; Louis Lambrechts. Cell-Fusing Agent Virus Reduces Arbovirus Dissemination in Aedes aegypti Mosquitoes In Vivo. Journal of Virology 2019, 93, 1 .

AMA Style

Artem Baidaliuk, Elliott Miot, Sebastian Lequime, Isabelle Moltini-Conclois, Fanny Delaigue, Stéphanie Dabo, Laura B. Dickson, Fabien Aubry, Sarah H. Merkling, Van-Mai Cao-Lormeau, Louis Lambrechts. Cell-Fusing Agent Virus Reduces Arbovirus Dissemination in Aedes aegypti Mosquitoes In Vivo. Journal of Virology. 2019; 93 (18):1.

Chicago/Turabian Style

Artem Baidaliuk; Elliott Miot; Sebastian Lequime; Isabelle Moltini-Conclois; Fanny Delaigue; Stéphanie Dabo; Laura B. Dickson; Fabien Aubry; Sarah H. Merkling; Van-Mai Cao-Lormeau; Louis Lambrechts. 2019. "Cell-Fusing Agent Virus Reduces Arbovirus Dissemination in Aedes aegypti Mosquitoes In Vivo." Journal of Virology 93, no. 18: 1.

Journal article
Published: 01 August 2019 in Emerging Infectious Diseases
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Zika and chikungunya viruses were first detected in Fiji in 2015. Examining surveillance and phylogenetic and serologic data, we found evidence of low-level transmission of Zika and chikungunya viruses during 2013-2017, in contrast to the major outbreaks caused by closely related virus strains in other Pacific Island countries.

ACS Style

Mike Kama; Maite Aubry; M. Kama Et Al.; Jessica Vanhomwegen; Teheipuaura Mariteragi-Helle; Anita Teissier; Tuterarii Paoaafaite; Stéphane Hué; Martin Hibberd; Jean-Claude Manuguerra; Ketan Christi; Conall H. Watson; Eric Nilles; John Aaskov; Colleen L. Lau; Didier Musso; Adam J. Kucharski; Van-Mai Cao-Lormeau. Sustained Low-Level Transmission of Zika and Chikungunya Viruses after Emergence in the Fiji Islands. Emerging Infectious Diseases 2019, 25, 1535 -1538.

AMA Style

Mike Kama, Maite Aubry, M. Kama Et Al., Jessica Vanhomwegen, Teheipuaura Mariteragi-Helle, Anita Teissier, Tuterarii Paoaafaite, Stéphane Hué, Martin Hibberd, Jean-Claude Manuguerra, Ketan Christi, Conall H. Watson, Eric Nilles, John Aaskov, Colleen L. Lau, Didier Musso, Adam J. Kucharski, Van-Mai Cao-Lormeau. Sustained Low-Level Transmission of Zika and Chikungunya Viruses after Emergence in the Fiji Islands. Emerging Infectious Diseases. 2019; 25 (8):1535-1538.

Chicago/Turabian Style

Mike Kama; Maite Aubry; M. Kama Et Al.; Jessica Vanhomwegen; Teheipuaura Mariteragi-Helle; Anita Teissier; Tuterarii Paoaafaite; Stéphane Hué; Martin Hibberd; Jean-Claude Manuguerra; Ketan Christi; Conall H. Watson; Eric Nilles; John Aaskov; Colleen L. Lau; Didier Musso; Adam J. Kucharski; Van-Mai Cao-Lormeau. 2019. "Sustained Low-Level Transmission of Zika and Chikungunya Viruses after Emergence in the Fiji Islands." Emerging Infectious Diseases 25, no. 8: 1535-1538.

Journal article
Published: 18 July 2019 in Eurosurveillance
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In 1996–97, the last dengue virus serotype 2 (DENV-2) outbreak occurred in French Polynesia. In February 2019, DENV-2 infection was detected in a traveller from New Caledonia. In March, autochthonous DENV-2 infection was diagnosed in two residents. A DENV-2 outbreak was declared on 10 April with 106 cases as at 24 June. Most of the population is not immune to DENV-2; a large epidemic could occur with risk of imported cases in mainland France.

ACS Style

Maite Aubry; Mihiau Mapotoeke; Anita Teissier; Tuterarii Paoaafaite; Elsa Dumas-Chastang; Marine Giard; Van-Mai Cao-Lormeau. Dengue virus serotype 2 (DENV-2) outbreak, French Polynesia, 2019. Eurosurveillance 2019, 24, 1 .

AMA Style

Maite Aubry, Mihiau Mapotoeke, Anita Teissier, Tuterarii Paoaafaite, Elsa Dumas-Chastang, Marine Giard, Van-Mai Cao-Lormeau. Dengue virus serotype 2 (DENV-2) outbreak, French Polynesia, 2019. Eurosurveillance. 2019; 24 (29):1.

Chicago/Turabian Style

Maite Aubry; Mihiau Mapotoeke; Anita Teissier; Tuterarii Paoaafaite; Elsa Dumas-Chastang; Marine Giard; Van-Mai Cao-Lormeau. 2019. "Dengue virus serotype 2 (DENV-2) outbreak, French Polynesia, 2019." Eurosurveillance 24, no. 29: 1.

Review article
Published: 10 June 2019 in New Microbes and New Infections
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The circulation of arthropod-borne viruses (arboviruses) throughout the Pacific is no exception in French Polynesia (FP). We review here the mosquito vectors involved or potentially involved in the transmission of arboviruses in FP. We highlight Aedes aegypti and Aedes polynesiensis; species that are widely distributed in FP and whose ability to transmit dengue, zika and chikungunya viruses is well known. In addition, we discuss the contribution of those species and the abundant Culex annulirostris to the silent circulation of Ross River virus in FP. As these mosquito species and others present in FP are known to be vectors of a large panel of arboviruses, there is a high risk for new emergences.

ACS Style

V. Richard; V.-M. Cao-Lormeau. Mosquito vectors of arboviruses in French Polynesia. New Microbes and New Infections 2019, 31, 100569 .

AMA Style

V. Richard, V.-M. Cao-Lormeau. Mosquito vectors of arboviruses in French Polynesia. New Microbes and New Infections. 2019; 31 ():100569.

Chicago/Turabian Style

V. Richard; V.-M. Cao-Lormeau. 2019. "Mosquito vectors of arboviruses in French Polynesia." New Microbes and New Infections 31, no. : 100569.

Journal article
Published: 01 April 2019 in Emerging Infectious Diseases
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A unique outbreak of Ross River virus (RRV) infection was reported in Fiji in 1979. In 2013, RRV seroprevalence among residents was 46.5% (362/778). Of the residents who were seronegative in 2013 and retested in 2015, 10.9% (21/192) had seroconverted to RRV, suggesting ongoing endemic circulation of RRV in Fiji.

ACS Style

Maite Aubry; Mike Kama; Jessica Vanhomwegen; Anita Teissier; Teheipuaura Mariteragi-Helle; Stephane Hue; Martin Hibberd; Jean-Claude Manuguerra; Ketan Christi; Conall Watson; Eric J. Nilles; Colleen L. Lau; John Aaskov; Didier Musso; Adam J. Kucharski; Van-Mai Cao-Lormeau. Ross River Virus Antibody Prevalence, Fiji Islands, 2013-2015. Emerging Infectious Diseases 2019, 25, 827 -830.

AMA Style

Maite Aubry, Mike Kama, Jessica Vanhomwegen, Anita Teissier, Teheipuaura Mariteragi-Helle, Stephane Hue, Martin Hibberd, Jean-Claude Manuguerra, Ketan Christi, Conall Watson, Eric J. Nilles, Colleen L. Lau, John Aaskov, Didier Musso, Adam J. Kucharski, Van-Mai Cao-Lormeau. Ross River Virus Antibody Prevalence, Fiji Islands, 2013-2015. Emerging Infectious Diseases. 2019; 25 (4):827-830.

Chicago/Turabian Style

Maite Aubry; Mike Kama; Jessica Vanhomwegen; Anita Teissier; Teheipuaura Mariteragi-Helle; Stephane Hue; Martin Hibberd; Jean-Claude Manuguerra; Ketan Christi; Conall Watson; Eric J. Nilles; Colleen L. Lau; John Aaskov; Didier Musso; Adam J. Kucharski; Van-Mai Cao-Lormeau. 2019. "Ross River Virus Antibody Prevalence, Fiji Islands, 2013-2015." Emerging Infectious Diseases 25, no. 4: 827-830.

Preprint
Published: 15 March 2019
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SUMMARYBackgroundSerosurveys published following major outbreaks of Zika virus (ZIKV) have so far shown a high level of seroprevalence from samples collected within 12 months of the first confirmed case. A common assumption is that ZIKV infection confers long-term protection against reinfection, preventing ZIKV from re-emerging in previously affected areas for many years. However, the long-term immune response to ZIKV following an outbreak remains poorly documented.MethodsWe compared results from eight serological surveys, with sample sizes ranging from 49 to 700, before and after known ZIKV outbreaks in the Pacific region: five from cross-sectional studies of schoolchildren and the general population in French Polynesia over a seven-year period; and three from a longitudinal cohort in Fiji over a four-year period.FindingsWe found strong evidence of a decline in seroprevalence in both countries over a two-year period following first reported ZIKV transmission. In the cohort in Fiji, there was also a significant decline in antibody titres against ZIKV. However, the decline in seroprevalence was concentrated in adults, while high seroprevalence persisted in children.InterpretationThe observed patterns of long-term anti-ZIKV antibody levels following outbreaks in the Pacific could be an early indication of the dynamics of population immunity in Latin America. Given that ZIKV antibody levels can wane substantially over time, follow-up seroprevalence studies and prospective clinical trial designs in Latin America may need to be revised, and assumptions about the potential for ZIKV to re-emerge may need to be revisited.FundingPacific Funds, ANR, MRC, Wellcome, Royal Society.

ACS Style

Alasdair D Henderson; Maite Aubry; Mike Kama; Jessica Vanhomwegen; Anita Teissier; Teheipuaura Mariteragi-Helle; Tuterarii Paoaafaite; Jean-Claude Manuguerra; W John Edmunds; Jimmy Whitworth; Conall H Watson; Colleen L Lau; Van-Mai Cao-Lormeau; Adam J Kucharski. Zika virus seroprevalence declines and neutralization antibodies wane in adults following outbreaks in French Polynesia and Fiji. 2019, 578211 .

AMA Style

Alasdair D Henderson, Maite Aubry, Mike Kama, Jessica Vanhomwegen, Anita Teissier, Teheipuaura Mariteragi-Helle, Tuterarii Paoaafaite, Jean-Claude Manuguerra, W John Edmunds, Jimmy Whitworth, Conall H Watson, Colleen L Lau, Van-Mai Cao-Lormeau, Adam J Kucharski. Zika virus seroprevalence declines and neutralization antibodies wane in adults following outbreaks in French Polynesia and Fiji. . 2019; ():578211.

Chicago/Turabian Style

Alasdair D Henderson; Maite Aubry; Mike Kama; Jessica Vanhomwegen; Anita Teissier; Teheipuaura Mariteragi-Helle; Tuterarii Paoaafaite; Jean-Claude Manuguerra; W John Edmunds; Jimmy Whitworth; Conall H Watson; Colleen L Lau; Van-Mai Cao-Lormeau; Adam J Kucharski. 2019. "Zika virus seroprevalence declines and neutralization antibodies wane in adults following outbreaks in French Polynesia and Fiji." , no. : 578211.

Review article
Published: 08 February 2019 in New Microbes and New Infections
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In French Polynesia, arthropod-borne diseases are major public health problems. From the mid-1940s, the four serotypes of dengue virus (DENV-1 to -4) have caused 15 epidemics of variable severity. In 2013, for the first time, a sustained co-circulation of two different DENV serotypes (DENV-1 and -3) was reported. The same year, Zika virus (ZIKV) caused the largest outbreak ever recorded at that time. Severe neurologic complications in adults, including Guillain-Barré syndrome and central nervous system malformations in newborns and foeteuses, such as microcephaly, were reported, and a causal link with ZIKV infection was established. In addition to mosquito-borne transmission, the potential for perinatal, sexual and blood-transfusion transmission of ZIKV was demonstrated. In 2014, chikungunya virus (CHIKV) caused an explosive outbreak. Series of Guillain-Barré syndrome temporally associated with the CHIKV epidemic were reported. Except for DENV, ZIKV and CHIKV, no other arboviruses have been detected so far, but serologic evidence suggested the past silent circulation of Ross River virus. From May 2015 DENV-1 has been the only arbovirus transmitted in French Polynesia, but the reemergence of DENV-2 is highly expected since the detection of two autochthonous cases of DENV-2 infection in June 2018.

ACS Style

M. Aubry; V.-M. Cao-Lormeau. History of arthropod-borne virus infections in French Polynesia. New Microbes and New Infections 2019, 29, 100513 .

AMA Style

M. Aubry, V.-M. Cao-Lormeau. History of arthropod-borne virus infections in French Polynesia. New Microbes and New Infections. 2019; 29 ():100513.

Chicago/Turabian Style

M. Aubry; V.-M. Cao-Lormeau. 2019. "History of arthropod-borne virus infections in French Polynesia." New Microbes and New Infections 29, no. : 100513.

Historical article
Published: 01 October 2018 in Emerging Infectious Diseases
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Congenital Zika virus syndrome consists of a large spectrum of neurologic abnormalities seen in infants infected with Zika virus in utero. However, little is known about the effects of Zika virus intrauterine infection on the neurocognitive development of children born without birth defects. Using a case-control study design, we investigated the temporal association of a cluster of congenital defects with Zika virus infection. In a nested study, we also assessed the early childhood development of children recruited in the initial study as controls who were born without known birth defects,. We found evidence for an association of congenital defects with both maternal Zika virus seropositivity (time of infection unknown) and symptomatic Zika virus infection during pregnancy. Although the early childhood development assessment found no excess burden of developmental delay associated with maternal Zika virus infection, larger, longer-term studies are needed.

ACS Style

Lorenzo Subissi; Timothée Dub; Marianne Besnard; Teheipuaura Mariteragi-Helle; Tuxuan Nhan; Delphine Lutringer-Magnin; Philippe Barboza; Céline Gurry; Pauline Brindel; Eric J. Nilles; David Baud; Angela Merianos; Didier Musso; Judith R. Glynn; Gilles Dupuis; Van-Mai Cao-Lormeau; Marine Giard; Henri-Pierre Mallet. Zika Virus Infection during Pregnancy and Effects on Early Childhood Development, French Polynesia, 2013–2016. Emerging Infectious Diseases 2018, 24, 1850 -1858.

AMA Style

Lorenzo Subissi, Timothée Dub, Marianne Besnard, Teheipuaura Mariteragi-Helle, Tuxuan Nhan, Delphine Lutringer-Magnin, Philippe Barboza, Céline Gurry, Pauline Brindel, Eric J. Nilles, David Baud, Angela Merianos, Didier Musso, Judith R. Glynn, Gilles Dupuis, Van-Mai Cao-Lormeau, Marine Giard, Henri-Pierre Mallet. Zika Virus Infection during Pregnancy and Effects on Early Childhood Development, French Polynesia, 2013–2016. Emerging Infectious Diseases. 2018; 24 (10):1850-1858.

Chicago/Turabian Style

Lorenzo Subissi; Timothée Dub; Marianne Besnard; Teheipuaura Mariteragi-Helle; Tuxuan Nhan; Delphine Lutringer-Magnin; Philippe Barboza; Céline Gurry; Pauline Brindel; Eric J. Nilles; David Baud; Angela Merianos; Didier Musso; Judith R. Glynn; Gilles Dupuis; Van-Mai Cao-Lormeau; Marine Giard; Henri-Pierre Mallet. 2018. "Zika Virus Infection during Pregnancy and Effects on Early Childhood Development, French Polynesia, 2013–2016." Emerging Infectious Diseases 24, no. 10: 1850-1858.

Journal article
Published: 28 August 2018 in American Journal of Epidemiology
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Since the 2007 Zika epidemic in Yap, it has been apparent that not all people infected with Zika virus (ZIKV) experience symptoms. However, the proportion of infections that result in symptoms remains unclear. Existing estimates varied in their interpretation of symptoms due to other causes and the case definition used, and assumed perfect test sensitivity and specificity. Using a Bayesian model and data from ZIKV serosurveys in Yap (2007), French Polynesia (2013-14), and Puerto Rico (2016), we found that assuming perfect sensitivity and specificity generally led to lower estimates of the symptomatic proportion. Incorporating reasonable assumptions for assay sensitivity and specificity, we estimated that 27% (95% Credible Interval: 15–37%) (Yap), 44% (26-66%) (French Polynesia), and 50% (34-92%) (Puerto Rico) of infections were symptomatic, with variation due to differences in study populations, study designs, and case definitions. The proportion of ZIKV infections causing symptoms is critical for surveillance system design and impact assessment. Here, we accounted for key uncertainties in existing seroprevalence data and found that estimates for the symptomatic proportion ranged from 27% to 50%, suggesting that while the majority of infections are asymptomatic or mildly symptomatic, symptomatic infections might be more common than previously estimated.

ACS Style

Patrick K Mitchell; Luis Mier-Y-Teran-Romero; Brad J Biggerstaff; Mark J Delorey; Maite Aubry; Van-Mai Cao-Lormeau; Matthew J Lozier; Simon Cauchemez; Michael A Johansson. Reassessing Serosurvey-Based Estimates of the Symptomatic Proportion of Zika Virus Infections. American Journal of Epidemiology 2018, 188, 206 -213.

AMA Style

Patrick K Mitchell, Luis Mier-Y-Teran-Romero, Brad J Biggerstaff, Mark J Delorey, Maite Aubry, Van-Mai Cao-Lormeau, Matthew J Lozier, Simon Cauchemez, Michael A Johansson. Reassessing Serosurvey-Based Estimates of the Symptomatic Proportion of Zika Virus Infections. American Journal of Epidemiology. 2018; 188 (1):206-213.

Chicago/Turabian Style

Patrick K Mitchell; Luis Mier-Y-Teran-Romero; Brad J Biggerstaff; Mark J Delorey; Maite Aubry; Van-Mai Cao-Lormeau; Matthew J Lozier; Simon Cauchemez; Michael A Johansson. 2018. "Reassessing Serosurvey-Based Estimates of the Symptomatic Proportion of Zika Virus Infections." American Journal of Epidemiology 188, no. 1: 206-213.

Journal article
Published: 14 August 2018 in eLife
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Dengue is a major health burden, but it can be challenging to examine transmission and evaluate control measures because outbreaks depend on multiple factors, including human population structure, prior immunity and climate. We combined population-representative paired sera collected before and after the 2013/14 dengue-3 outbreak in Fiji with surveillance data to determine how such factors influence transmission and control in island settings. Our results suggested the 10–19 year-old age group had the highest risk of infection, but we did not find strong evidence that other demographic or environmental risk factors were linked to seroconversion. A mathematical model jointly fitted to surveillance and serological data suggested that herd immunity and seasonally varying transmission could not explain observed dynamics. However, the model showed evidence of an additional reduction in transmission coinciding with a vector clean-up campaign, which may have contributed to the decline in cases in the later stages of the outbreak.

ACS Style

Adam J Kucharski; Mike Kama; Conall H Watson; Maite Aubry; Sebastian Funk; Alasdair D Henderson; Oliver J Brady; Jessica Vanhomwegen; Jean-Claude Manuguerra; Colleen L Lau; W John Edmunds; John Aaskov; Eric James Nilles; Van-Mai Cao-Lormeau; Stéphane Hué; Martin L Hibberd. Using paired serology and surveillance data to quantify dengue transmission and control during a large outbreak in Fiji. eLife 2018, 7, 1 .

AMA Style

Adam J Kucharski, Mike Kama, Conall H Watson, Maite Aubry, Sebastian Funk, Alasdair D Henderson, Oliver J Brady, Jessica Vanhomwegen, Jean-Claude Manuguerra, Colleen L Lau, W John Edmunds, John Aaskov, Eric James Nilles, Van-Mai Cao-Lormeau, Stéphane Hué, Martin L Hibberd. Using paired serology and surveillance data to quantify dengue transmission and control during a large outbreak in Fiji. eLife. 2018; 7 ():1.

Chicago/Turabian Style

Adam J Kucharski; Mike Kama; Conall H Watson; Maite Aubry; Sebastian Funk; Alasdair D Henderson; Oliver J Brady; Jessica Vanhomwegen; Jean-Claude Manuguerra; Colleen L Lau; W John Edmunds; John Aaskov; Eric James Nilles; Van-Mai Cao-Lormeau; Stéphane Hué; Martin L Hibberd. 2018. "Using paired serology and surveillance data to quantify dengue transmission and control during a large outbreak in Fiji." eLife 7, no. : 1.

Research article
Published: 17 July 2018 in PLOS Neglected Tropical Diseases
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In 2013, Zika virus (ZIKV) emerged in French Polynesia and spread through the Pacific region between 2013 and 2017. Several potential Aedes mosquitoes may have contributed to the ZIKV transmission including Aedes aegypti, the main arbovirus vector in the region, and Aedes polynesiensis, vector of lymphatic filariasis and secondary vector of dengue virus. The aim of this study was to analyze the ability of these two Pacific vectors to transmit ZIKV at a regional scale, through the evaluation and comparison of the vector competence of wild Ae. aegypti and Ae. polynesiensis populations from different Pacific islands for a ZIKV strain which circulated in this region during the 2013–2017 outbreak. Field Ae. aegypti (three populations) and Ae. polynesiensis (two populations) from the Pacific region were collected for this study. Female mosquitoes were orally exposed to ZIKV (107 TCID50/mL) isolated in the region in 2014. At 6, 9, 14 and 21 days post-infection, mosquito bodies (thorax and abdomen), heads and saliva were analyzed to measure infection, dissemination, transmission rates and transmission efficiency, respectively. According to our results, ZIKV infection rates were heterogeneous between the Ae. aegypti populations, but the dissemination rates were moderate and more homogenous between these populations. For Ae. polynesiensis, infection rates were less heterogeneous between the two populations tested. The transmission rate and efficiency results revealed a low vector competence for ZIKV of the different Aedes vector populations under study. Our results indicated a low ZIKV transmission by Ae. aegypti and Ae. polynesiensis tested from the Pacific region. These results were unexpected and suggest the importance of other factors especially the vector density, the mosquito lifespan or the large immunologically naive fraction of the population that may have contributed to the rapid spread of the ZIKV in the Pacific region during the 2013–2017 outbreak. Zika virus (ZIKV) was isolated for the first time in Uganda in 1947. The virus was sporadically detected in Africa and Asia during few decades. The first human outbreak was declared in Yap Island in Micronesia in 2007. The virus reemerged in 2013 in French Polynesia and circulated throughout the Pacific region and in Americas between 2013 and 2017. ZIKV is transmitted to human by the bite of an infected mosquito. Aedes mosquitoes were particularly incriminated in the ZIKV outbreak. In this study, we showed for the first time the results of vector competence study of wild Aedes aegypti and Aedes polynesiensis from different islands of the Pacific region. Our results demonstrated an unexpected homogenous and low ZIKV vector competence for the different populations of these two vectors. These findings seemed to indicate that other factors have contributed to the rapid spread of ZIKV in the Pacific region.

ACS Style

Elodie Calvez; Laurence Mousson; Marie Vazeille; Olivia O'Connor; Van-Mai Cao-Lormeau; Francoise Mathieu-Daude; Nicolas Pocquet; Anna-Bella Failloux; Myrielle Dupont-Rouzeyrol. Zika virus outbreak in the Pacific: Vector competence of regional vectors. PLOS Neglected Tropical Diseases 2018, 12, e0006637 .

AMA Style

Elodie Calvez, Laurence Mousson, Marie Vazeille, Olivia O'Connor, Van-Mai Cao-Lormeau, Francoise Mathieu-Daude, Nicolas Pocquet, Anna-Bella Failloux, Myrielle Dupont-Rouzeyrol. Zika virus outbreak in the Pacific: Vector competence of regional vectors. PLOS Neglected Tropical Diseases. 2018; 12 (7):e0006637.

Chicago/Turabian Style

Elodie Calvez; Laurence Mousson; Marie Vazeille; Olivia O'Connor; Van-Mai Cao-Lormeau; Francoise Mathieu-Daude; Nicolas Pocquet; Anna-Bella Failloux; Myrielle Dupont-Rouzeyrol. 2018. "Zika virus outbreak in the Pacific: Vector competence of regional vectors." PLOS Neglected Tropical Diseases 12, no. 7: e0006637.