For many years, image classification – mainly based on pixel brightness statistics – has been among themost popular remote sensing applications. However, during recent years, many users were more andmore interested in the application-oriented semantic labelling of remotely sensed image objects beingdepicted in given images.In parallel, the development of deep learning algorithms has led to several powerful imageclassification and annotation tools that became popular in the remote sensing community. In mostcases, these publicly available tools combine efficient algorithms with expert knowledge and/orexternal information ingested during an initial training phase, and we often encounter two alternativetypes of deep learning approaches, namely Autoencoders (AEs) and Convolutional Neural Networks(CNNs). Both approaches try to convert the pixel data of remote sensing images into semantic maps ofthe imaged areas.In our case, we made an attempt to provide an efficient new semantic annotation tool that helps inthe semantic interpretation of newly recorded images with known and/or possibly unknown content.Typical cases are remote sensing images depicting unexpected and hitherto uncharted phenomenasuch as flooding events or destroyed infrastructure. When we resort to the commonly applied AE orCNN software packages we cannot expect that existing statistics, or a few initial ground-truthannotations made by an image interpreter, will automatically lead to a perfect understanding of theimage content. Instead, we have to discover and combine a number of additional relationships thatdefine the actual content of a selected image and many of its characteristics.Our approach consists of a two-stage domain-change approach where we first convert an image intoa purely mathematical ‘topic representation’ initially introduced by Blei [1]. This representationprovides statistics-based topics that do not yet require final application-oriented labelling describingphysical categories or phenomena and support the idea of explainable machine learning [2]. Then,during a second stage, we try to derive physical image content categories by exploiting a weightedmulti-level neural network approach that converts weighted topics into individual application-orientedlabels. This domain-changing learning stage limits label noise and is initially supported by an imageinterpreter allowing the joint use of pixel statistics and expert knowledge [3]. The activity of the imageinterpreter can be limited to a few image patches.We tested our approach on a number of different use cases (e.g., polar ice, agriculture, naturaldisasters) and found that our concept provides promising results. [1] D.M. Blei, A.Y. Ng, and M.I. Jordan, (2003). Latent Dirichlet Allocation, Journal of Machine LearningResearch, Vol. 3, pp. 993-1022.[2] C. Karmakar, C.O. Dumitru, G. Schwarz, and M. Datcu (2020). Feature-free explainable data miningin SAR images using latent Dirichlet allocation, IEEE Journal of Selected Topics in Applied EarthObservations and Remote Sensing, Vol. 14, pp. 676-689.[3] C.O. Dumitru, G. Schwarz, and M. Datcu (2021). Semantic Labelling of Globally Distributed Urbanand Non-Urban Satellite Images Using High-Resolution SAR Data, IEEE Journal of Selected Topics inApplied Earth Observations and Remote Sensing, Vol. 15, pp. 6009-6068.