Dr. Plow has a longstanding interest in plasminogen and its receptors, and he received NIH grants for these studies for more than 40 years. He and his colleagues were the first to demonstrate that cells express plasminogen receptors and that the same cell can assemble both plasminogen and plasminogen activator into an efficient plasmin-generating system. There are now more than 6000 PubMed citations on plasminogen receptors. He and his colleagues were the first to isolate a plasminogen receptor, and he has used animal models to illustrate the importance of plasminogen and its receptors in a diverse array of inflammatory responses. Histone 2B was identified as a regulated plasminogen receptor in 2006, and its function as a plasminogen receptor has been demonstrated both in vitro and in vivo.