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Exposure to air pollution has been linked with altered immune function in adults, but little is known about its effects on early life. This study aimed to investigate the effects of exposure to air pollution during prenatal and postnatal windows on cell-mediated immune function in preschoolers. Pre-school aged children (2.9 ± 0.5 y old, n = 391) were recruited from a mother-child cohort study in Wuhan, China. We used a spatial-temporal land use regression (LUR) model to estimate exposures of particulate matter with aerodynamic diameters ≤2.5 μm (PM2.5) and ≤10 μm (PM10), and nitrogen dioxide (NO2) during the specific trimesters of pregnancy and the first two postnatal years. We measured peripheral blood T lymphocyte subsets and plasma cytokines as indicators of cellular immune function. We used multiple informant models to examine the associations of prenatal and postnatal exposures to air pollution with cell-mediated immune function. Prenatal exposures to PM2.5, PM10, and NO2 during early pregnancy were negatively associated with %CD3+ and %CD3+CD8+ cells, and during late pregnancy were positively associated with %CD3+ cells. Postnatal exposures to these air pollutants during 1-y or 2-y childhood were positively associated with IL-4, IL-5, IL-6, and TNF-α. We also observed that the associations of prenatal or postnatal air pollution exposures with cellular immune responses varied by child's sex. Our results suggest that exposure to air pollution during different critical windows of early life may differentially alter cellular immune responses, and these effects appear to be sex-specific.
Yan-Ling Deng; Jia-Qiang Liao; Bin Zhou; Wen-Xin Zhang; Chong Liu; Xiao-Qiong Yuan; Pan-Pan Chen; Yu Miao; Qiong Luo; Fei-Peng Cui; Min Zhang; Sheng-Zhi Sun; Tong-Zhang Zheng; Wei Xia; Yuan-Yuan Li; Shun-Qing Xu; Qiang Zeng. Early life exposure to air pollution and cell-mediated immune responses in preschoolers. Chemosphere 2021, 286, 131963 .
AMA StyleYan-Ling Deng, Jia-Qiang Liao, Bin Zhou, Wen-Xin Zhang, Chong Liu, Xiao-Qiong Yuan, Pan-Pan Chen, Yu Miao, Qiong Luo, Fei-Peng Cui, Min Zhang, Sheng-Zhi Sun, Tong-Zhang Zheng, Wei Xia, Yuan-Yuan Li, Shun-Qing Xu, Qiang Zeng. Early life exposure to air pollution and cell-mediated immune responses in preschoolers. Chemosphere. 2021; 286 ():131963.
Chicago/Turabian StyleYan-Ling Deng; Jia-Qiang Liao; Bin Zhou; Wen-Xin Zhang; Chong Liu; Xiao-Qiong Yuan; Pan-Pan Chen; Yu Miao; Qiong Luo; Fei-Peng Cui; Min Zhang; Sheng-Zhi Sun; Tong-Zhang Zheng; Wei Xia; Yuan-Yuan Li; Shun-Qing Xu; Qiang Zeng. 2021. "Early life exposure to air pollution and cell-mediated immune responses in preschoolers." Chemosphere 286, no. : 131963.
Fungicides are widely used in agriculture worldwide. However, data on the occurrence of fungicides in drinking water are scarce. This study aimed to determine the occurrence of 12 selected fungicides in drinking water, the removal efficiency of conventional water treatment processes for fungicides, and the risk of fungicide exposure. In this study, source water (February and July), treated water (February and July), and tap water samples (February, April, July, and October) were collected from Wuhan, central China, in 2019. Seven of the twelve selected fungicides were 100% detected in the three types of water samples; tricyclazole was found with the highest concentrations in the source water phase (median: 15.2 ng/L; range: 4.21–67.9 ng/L). The concentrations of the 12 selected fungicides remaining in the treated water samples (median proportion of the remaining content: 77.5%) revealed that most of the target analytes may not be removed efficiently by conventional water treatment processes, though they could be removed efficiently by advanced treatment. Higher concentrations of the fungicides were observed in samples collected in July (median: 38.7 ng/L; range: 12.5–85.8 ng/L), followed by those in October (median: 21.8 ng/L; range: 10.2–58.8 ng/L), February (median: 9.82 ng/L; range: 5.63–93.3 ng/L), and April (median: 7.13 ng/L; range: 6.23–91.1 ng/L). The health risk assessment implied that estimated daily intake of these fungicides through tap water ingestion might pose a low risk to consumers, though risk associated with infant exposure to the fungicides requires further attention. This study provides baseline data on the occurrence, removal efficiencies, and seasonal variations of the selected fungicides in tap water from central China.
Juan Liu; Wei Xia; Yanjian Wan; Shunqing Xu. Azole and strobilurin fungicides in source, treated, and tap water from Wuhan, central China: Assessment of human exposure potential. Science of The Total Environment 2021, 801, 149733 .
AMA StyleJuan Liu, Wei Xia, Yanjian Wan, Shunqing Xu. Azole and strobilurin fungicides in source, treated, and tap water from Wuhan, central China: Assessment of human exposure potential. Science of The Total Environment. 2021; 801 ():149733.
Chicago/Turabian StyleJuan Liu; Wei Xia; Yanjian Wan; Shunqing Xu. 2021. "Azole and strobilurin fungicides in source, treated, and tap water from Wuhan, central China: Assessment of human exposure potential." Science of The Total Environment 801, no. : 149733.
General population are concurrently and extensively exposed to many volatile organic compounds (VOCs), including some Group 1 human carcinogens, such as 1,3-butadiene. However, only a few studies assessed internal exposure levels of VOCs; particularly, very limited studies have examined associations between the urinary concentrations of multiple VOC metabolites (mVOCs) and oxidative stress biomarkers (OSBs) among the general population. In this study, 21 mVOCs and three OSBs including 8-hydroxy-2′-deoxyguanosine (8-OHdG; for DNA), 8-hydroxyguanosine (8-OHG; for RNA), and 4-hydroxy nonenal mercapturic acid (HNEMA; for lipid) were measured in 406 urine samples collected from 128 healthy adults during autumn and winter of 2018 in Wuhan, central China, including repeated samples taken in 3 d from 75 volunteers. Inter-day reproducibility for most mVOCs was good to excellent; urinary concentrations of mVOCs in winter were generally higher than those in autumn. Risk assessment was conducted by calculating hazard quotients for the parent compounds, and the results suggested that acrolein, 1,3-butadiene, and cyanide should be considered as high-priority hazardous ones for management. After false-discovery adjustment, 16 of the studied mVOCs were positively associated with 8-OHdG and 8-OHG (β values ranged from 0.04 to 0.48), and four mVOCs were positively associated with HNEMA (β values ranged from 0.21 to 0.78). Weighted quantile sum regression analyses were used to assess associations of mVOC mixture and OSBs, and we found significantly positive associations between the mixture index and OSBs, among which the strongest mVOC contributors for the associations were 2-methylhippuric acid for both DNA (20%) and RNA (17%) oxidative damage, and trans,trans-muconic acid (50%) for lipid peroxidation. This study firstly reported good to excellent short-term reproducibility, seasonal difference in autumn and winter, and possible health risk in urinary concentrations of multiple mVOCs among the general population.
Xi Qian; Yanjian Wan; Aizhen Wang; Wei Xia; Zong Yang; Zhenyu He; Shunqing Xu. Urinary metabolites of multiple volatile organic compounds among general population in Wuhan, central China: Inter-day reproducibility, seasonal difference, and their associations with oxidative stress biomarkers. Environmental Pollution 2021, 289, 117913 .
AMA StyleXi Qian, Yanjian Wan, Aizhen Wang, Wei Xia, Zong Yang, Zhenyu He, Shunqing Xu. Urinary metabolites of multiple volatile organic compounds among general population in Wuhan, central China: Inter-day reproducibility, seasonal difference, and their associations with oxidative stress biomarkers. Environmental Pollution. 2021; 289 ():117913.
Chicago/Turabian StyleXi Qian; Yanjian Wan; Aizhen Wang; Wei Xia; Zong Yang; Zhenyu He; Shunqing Xu. 2021. "Urinary metabolites of multiple volatile organic compounds among general population in Wuhan, central China: Inter-day reproducibility, seasonal difference, and their associations with oxidative stress biomarkers." Environmental Pollution 289, no. : 117913.
A perinatal high-salt (HS) diet was reported to elevate plasma triglycerides. This study aimed to investigate the hypothesis that a perinatal HS diet predisposed offspring to non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of abnormal lipid metabolism, and the possible mechanism. Female C57BL/6 mice were fed a control diet (0.5% NaCl) or HS diet (4% NaCl) during pregnancy and lactation and their offspring were sacrificed at weaning. The perinatal HS diet induced greater variation in fecal microbial beta-diversity (β-diversity) and increased bacteria abundance of Proteobacteria and Bacteroides. The gut microbiota dysbiosis promoted bile acid homeostasis disbalance, characterized by the accumulation of lithocholic acid (LCA) and deoxycholic acid (DCA) in feces. These alterations disturbed gut barrier by increasing the expression of tight junction protein (Tjp) and occludin (Ocln), and increased systemic lipopolysaccharide (LPS) levels and hepatic inflammatory cytokine secretion (TNF-α and IL-6) in the liver. The perinatal HS diet also inhibited hepatic expression of hepatic FXR signaling (CYP7A1 and FXR), thus triggering increased hepatic expression of pro-inflammatory cytokines (TNF-α and IL-6) and hepatic lipid metabolism-associated genes (SREBP-1c, FAS, ACC), leading to unique characteristics of NAFLD. In conclusion, a perinatal HS diet induced NAFLD in weanling mice offspring; the possible mechanism was related to increased bacteria abundance of Proteobacteria and Bacteroides, increased levels of LCA and DCA in feces, and increased expressions of hepatic FXR signaling.
Qing Guo; Yi Tang; Ying Li; Ziyuan Xu; Di Zhang; Jiangtao Liu; Xin Wang; Wei Xia; Shunqing Xu. Perinatal High-Salt Diet Induces Gut Microbiota Dysbiosis, Bile Acid Homeostasis Disbalance, and NAFLD in Weanling Mice Offspring. Nutrients 2021, 13, 2135 .
AMA StyleQing Guo, Yi Tang, Ying Li, Ziyuan Xu, Di Zhang, Jiangtao Liu, Xin Wang, Wei Xia, Shunqing Xu. Perinatal High-Salt Diet Induces Gut Microbiota Dysbiosis, Bile Acid Homeostasis Disbalance, and NAFLD in Weanling Mice Offspring. Nutrients. 2021; 13 (7):2135.
Chicago/Turabian StyleQing Guo; Yi Tang; Ying Li; Ziyuan Xu; Di Zhang; Jiangtao Liu; Xin Wang; Wei Xia; Shunqing Xu. 2021. "Perinatal High-Salt Diet Induces Gut Microbiota Dysbiosis, Bile Acid Homeostasis Disbalance, and NAFLD in Weanling Mice Offspring." Nutrients 13, no. 7: 2135.
A growing body of evidence indicates that early-term births (37–38 weeks of gestational age) have an increased risk of short-term and long-term complications. Here, we sought to explore the association between early-term births and the risk of delayed neurodevelopment at age 2 years. Pregnant women and their live singleton birth were recruited from a single tertiary hospital between October 2013 and February 2017. Mental and Psychomotor Development Indexes (MDI and PDI) were assessed using the Bayley Scales of Infant Development (BSID). Delayed neurodevelopment was defined as scores of PDI or MDI less than −1SD relative to the mean score of the study population. In total, 1678 full-term infants and 727 early-term infants were assessed when they were 2 years old. After adjustment for potential confounders, early-term birth was related to 43% increased odds of neurodevelopmental delay in the PDI domain as compared with full-term birth (OR: 1.43; 95% CI: 1.12, 1.82). The observed associations were more prominent among those infants born by cesarean (OR: 1.44; 95% CI: 1.03, 2.00) and among males (OR: 1.66; 95% CI: 1.20, 2.28). No statistical difference in the MDI domain was found between early-term and full-term births. Conclusions: Our findings suggest that early-term birth was associated with increased odds of delayed neurodevelopment in the PDI domain as measured by BSID assessments at age 2 years. Health professionals should be aware of the influence of early-term birth on the risk of delayed neurodevelopment.
Mingyang Wu; Lulin Wang; Yunyun Liu; Jianing Bi; Qing Liu; Kai Chen; Yuanyuan Li; Wei Xia; Shunqing Xu; Aifen Zhou; Zhongqiang Cao; Youjie Wang; Rong Yang. Association between early-term birth and delayed neurodevelopment at the age of 2 years: results from a cohort study in China. European Journal of Pediatrics 2021, 1 -9.
AMA StyleMingyang Wu, Lulin Wang, Yunyun Liu, Jianing Bi, Qing Liu, Kai Chen, Yuanyuan Li, Wei Xia, Shunqing Xu, Aifen Zhou, Zhongqiang Cao, Youjie Wang, Rong Yang. Association between early-term birth and delayed neurodevelopment at the age of 2 years: results from a cohort study in China. European Journal of Pediatrics. 2021; ():1-9.
Chicago/Turabian StyleMingyang Wu; Lulin Wang; Yunyun Liu; Jianing Bi; Qing Liu; Kai Chen; Yuanyuan Li; Wei Xia; Shunqing Xu; Aifen Zhou; Zhongqiang Cao; Youjie Wang; Rong Yang. 2021. "Association between early-term birth and delayed neurodevelopment at the age of 2 years: results from a cohort study in China." European Journal of Pediatrics , no. : 1-9.
The associations of bisphenol A exposure during pregnancy with risk of preterm birth (PTB) and changes in gestational age have remained controversial. To conduct the meta-analysis, the relevant studies were searched through PubMed, OVID, and Web of Science from inception through June 17, 2020. Data were independently extracted and analyzed using odds ratio (OR) or regression coefficient (β) and their 95% confidence intervals (CIs). We identified 668 references and included 7 studies for preterm birth and 9 studies for gestational age. The included studies reported that the median or geometric mean (GM) of maternal urinary BPA ranged from 0.48 to 6.44 ng/ml. The meta-analysis estimated OR to be 1.36 (95% CI: 1.03, 1.69) for preterm birth associated with maternal urinary BPA exposure during pregnancy. In the subgroup analysis based on BPA exposure level, a significant association was observed between preterm birth and higher BPA exposure among the populations had BPA median or GM concentrations higher than 2.16 ng/ml (OR: 1.92; 95% CI: 1.38, 2.47). In the subgroup analyses by maternal urinary BPA exposure assessed in different trimesters, a significant association of preterm birth was only observed with BPA assessed in the third trimester (OR: 1.62; 95% CI: 1.15, 2.09). In addition, higher maternal urinary BPA exposure during pregnancy was associated with decreased gestational age by 0.50 (−0.87, −0.13) days, and the subgroup analyses also showed that only BPA exposure in the third trimester was associated with decreased gestational age by 1.36 (−2.21, −0.52) days. This meta-analysis demonstrated that higher BPA exposure was associated with an increased risk of preterm birth and decreased length of gestational age, and suggested that BPA exposure in the third trimester of pregnancy may be a critical susceptible period of preterm birth.
Asmagvl Namat; Wei Xia; Chao Xiong; Shunqing Xu; Chuansha Wu; Aizhen Wang; Yuanyuan Li; Yongning Wu; Jingguang Li. Association of BPA exposure during pregnancy with risk of preterm birth and changes in gestational age: A meta-analysis and systematic review. Ecotoxicology and Environmental Safety 2021, 220, 112400 .
AMA StyleAsmagvl Namat, Wei Xia, Chao Xiong, Shunqing Xu, Chuansha Wu, Aizhen Wang, Yuanyuan Li, Yongning Wu, Jingguang Li. Association of BPA exposure during pregnancy with risk of preterm birth and changes in gestational age: A meta-analysis and systematic review. Ecotoxicology and Environmental Safety. 2021; 220 ():112400.
Chicago/Turabian StyleAsmagvl Namat; Wei Xia; Chao Xiong; Shunqing Xu; Chuansha Wu; Aizhen Wang; Yuanyuan Li; Yongning Wu; Jingguang Li. 2021. "Association of BPA exposure during pregnancy with risk of preterm birth and changes in gestational age: A meta-analysis and systematic review." Ecotoxicology and Environmental Safety 220, no. : 112400.
The immunotoxicity induced by vanadium exposure have been reported in some toxicology researches. However, evidence from population-based epidemiological studies was lacking. This study was conducted to assess the associations between prenatal and postnatal exposure to vanadium and immune function of children. A total of 407 pre-school aged children were followed, whose peripheral blood was collected for T lymphocyte subsets and inflammatory cytokines analysis, as well as vanadium concentration measurement. Maternal urine samples were also collected to measure vanadium concentration. We used generalized linear models to evaluate the associations of maternal and children vanadium concentration with children’s immune function. Stratification analysis was further conducted to explore the potential gender-specific effects. The geometric means of vanadium concentration in maternal urine and children plasma were 0.85 and 1.12 μg/L, respectively. Maternal urinary vanadium was inversely associated with the percentage of CD3+CD4+ cells [-5.53 % (-10.38 %, -0.41 %)] and absolute counts of CD3+ cells [-2.43 % (-5.05 %, 0.25 %)], and we only observed significant negative associations in males when stratifying by fetal gender. Children plasma vanadium was also associated with reduced absolute counts of CD3+ cells [-5.25 % (-9.57 %, -0.73 %)], but gender-specific effects were not observed. No significant associations of vanadium exposure with cytokines were found. Prenatal and postnatal exposure to vanadium had suppressive impacts on childhood cellular immune. Further studies are needed to confirm our findings.
Wenxin Zhang; Huan Chen; Qiang Zeng; Shunqing Xu; Wei Xia; Yuanyuan Li. Prenatal and postnatal exposure to vanadium and the immune function of children. Journal of Trace Elements in Medicine and Biology 2021, 67, 126787 .
AMA StyleWenxin Zhang, Huan Chen, Qiang Zeng, Shunqing Xu, Wei Xia, Yuanyuan Li. Prenatal and postnatal exposure to vanadium and the immune function of children. Journal of Trace Elements in Medicine and Biology. 2021; 67 ():126787.
Chicago/Turabian StyleWenxin Zhang; Huan Chen; Qiang Zeng; Shunqing Xu; Wei Xia; Yuanyuan Li. 2021. "Prenatal and postnatal exposure to vanadium and the immune function of children." Journal of Trace Elements in Medicine and Biology 67, no. : 126787.
Fipronil (FP) is widely used as a highly effective insecticide worldwide, thereby raising concern about environmental contamination and risk for human health. However, data on the occurrence of FP and its transformation products (FPs) in human blood and urine are limited. In this study, 39 pairs of serum, plasma, blood cells (BCs), and urine samples were collected from adults in Wuhan, central China (2020), in order to characterize the concentration profiles of FPs in different matrices. FPs were also determined in serum samples (n = 226, including 57, 56, 56, and 57 samples for Wuhan, Huangshi, Nanjing, and Zhenjiang, respectively) collected from four cities of China (2015) to characterize the exposure levels of FPs among the general population and potential spatial variations. Fipronil sulfone (FP-SFO) was 100% detectable in blood samples, and it was the predominant metabolite (accounting for 86–95% of the cumulative concentrations of FPs [ΣFPs]), with the median concentrations (ng/mL) of 0.17, 0.16, and 0.03 in serum (range: 0.07–1.53), plasma (range: 0.06–1.41), and BCs (range: 0.01–0.24), respectively. The compositional profiles of FPs in serum, plasma, and BCs were similar; very strong positive correlations were observed between different blood matrices for FP-SFO (r = 0.94–0.97, p < 0.01) but not between blood and urine. The median ΣFPs (ng/mL) in the serum (0.20; range: 0.09–1.56) and the plasma samples (0.19; range: 0.09–1.43) was higher than that in BCs samples (0.04; range: 0.01–0.24). In the urine samples, only the major metabolite FP-SFO was detectable in approximately 10% of the samples. Additionally, the highest median ΣFPs (ng/mL) in the serum samples was found in Nanjing (0.56; range: 0.13–1.88), followed by Wuhan (0.34; range: 0.06–1.02), Huangshi (0.10; range: 0.03–0.60), and Zhenjiang (0.08; range: 0.02–0.42). The level of ΣFPs seemed to increase with city sizes and urbanization scale, though further studies are needed to confirm the variations with larger sample size. The estimated daily intake of ΣFPs based on the median concentration of samples from Nanjing (18.5 ng/kg-bw/d) was higher than that of Wuhan (11.3), Huangshi (3.40), and Zhenjiang (2.80). Dietary intake should be the major exposure route for the general population, while water or indoor dust accounted for <1% of the ΣFPs intake. This pilot study provided the first data on the profiles of FPs in paired human serum, plasma, BCs, and urine samples, and potential spatial variations of ΣFPs in China. FP-SFO and FP desulfinyl should be considered among priority substances worthy to be bio-monitored in China due to its moderated persistence and ubiquitous occurrence in human blood.
Lisha Shi; Yanjian Wan; Juan Liu; Zhenyu He; Shunqing Xu; Wei Xia. Insecticide fipronil and its transformation products in human blood and urine: Assessment of human exposure in general population of China. Science of The Total Environment 2021, 786, 147342 .
AMA StyleLisha Shi, Yanjian Wan, Juan Liu, Zhenyu He, Shunqing Xu, Wei Xia. Insecticide fipronil and its transformation products in human blood and urine: Assessment of human exposure in general population of China. Science of The Total Environment. 2021; 786 ():147342.
Chicago/Turabian StyleLisha Shi; Yanjian Wan; Juan Liu; Zhenyu He; Shunqing Xu; Wei Xia. 2021. "Insecticide fipronil and its transformation products in human blood and urine: Assessment of human exposure in general population of China." Science of The Total Environment 786, no. : 147342.
Prenatal exposure to di(2-ethylhexyl) phthalate (DEHP) may cause adverse health outcomes. However, trimester-specific impacts of DEHP exposure on offspring growth from fetal to early childhood stage have not been thoroughly evaluated. In this study, participants who provided a full series of urine specimens at three trimesters were selected from a birth cohort conducted at Wuhan, China from 2014 to 2015. 814 mother-offspring pairs were included in the study. Urinary concentrations of DEHP metabolites were determined using liquid chromatography-tandem mass spectrometry. Z-scores for ultrasound-measured fetal growth parameters at 14.0–18.9, 22.6–27.0, and 29.0–33.9 weeks of gestation, were calculated. Weight, height, and body mass index (BMI) at 6, 12, and 24 months were standardized to z-scores using sex-specific and age-specific WHO child growth standards. Linear regressions with generalized estimating equations were used to assess the relationships of DEHP levels per trimester to fetal growth, birth size, and growth at 6, 12, and 24 months to explore the trimester-specific impacts of DEHP exposure on offspring development. Among males, the1st-trimester DEHP was negatively related to fetal growth (β < 0, p < 0.05), but positively related to 24-month BMI. The 2nd-trimester DEHP was negatively related to birth weight and birth length, but positively related to weight gain rates from birth to 24 months old. The 3rd-trimester DEHP was positively (β > 0, p < 0.05) associated with birth weight and BMI at 6 and 12 months. Among females, the 1st-trimester DEHP was associated with increased birth length, while the 2nd-trimester DEHP was negatively associated with BMI at 6 and 12 months. A negative association between DEHP and weight gain rates at 6 months was noted among females. This prospective cohort revealed the sex-specific and trimester-specific relationships of DEHP exposure to offspring growth from fetal to early-childhood stage.
Jiufeng Li; Xi Qian; Yanqiu Zhou; Yuanyuan Li; Shunqing Xu; Wei Xia; Zongwei Cai. Trimester-specific and sex-specific effects of prenatal exposure to di(2-ethylhexyl) phthalate on fetal growth, birth size, and early-childhood growth: A longitudinal prospective cohort study. Science of The Total Environment 2021, 777, 146146 .
AMA StyleJiufeng Li, Xi Qian, Yanqiu Zhou, Yuanyuan Li, Shunqing Xu, Wei Xia, Zongwei Cai. Trimester-specific and sex-specific effects of prenatal exposure to di(2-ethylhexyl) phthalate on fetal growth, birth size, and early-childhood growth: A longitudinal prospective cohort study. Science of The Total Environment. 2021; 777 ():146146.
Chicago/Turabian StyleJiufeng Li; Xi Qian; Yanqiu Zhou; Yuanyuan Li; Shunqing Xu; Wei Xia; Zongwei Cai. 2021. "Trimester-specific and sex-specific effects of prenatal exposure to di(2-ethylhexyl) phthalate on fetal growth, birth size, and early-childhood growth: A longitudinal prospective cohort study." Science of The Total Environment 777, no. : 146146.
Metabolomics represents a powerful tool for measuring environmental exposures and biological responses to unveil potential mechanisms. Few studies have investigated the effects of exposure to fine particulate matter (PM2.5) longitudinally on serum metabolomics in regions with high-level PM2.5. Therefore, we examined the changes of serum metabolomics corresponding to individual PM2.5 exposure levels in spring and autumn among 63 healthy college students in Baoding city, Hebei, China. The metabolic profiling was determined by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. The average level of individual PM2.5 in the spring was 1.82-fold higher than in the autumn (240 μg/m3 vs 132 μg/m3). Males were exposed to a higher level of PM2.5 than females in the spring. Metabolic profiling was clearly separated by orthogonal partial least square-discriminant analysis in males but not in females. In the analysis of the associations between the metabolome and PM2.5 of the two seasons, the changes of 14 serum metabolites were significantly associated with PM2.5 in males. The metabolites related to heme metabolism (bilirubin, biliverdin), energy metabolism and oxidative stress (2-Octenoylcarnitine, N-Heptanoylglycine, and acetylcysteine), phospholipid metabolism (lysophosphatidic acid, phospholipid acid, and lysophosphatidylethanolamine), and tryptophan metabolism (N-Acetylserotonin, indolepyruvate, and melatonin) were decreased in the range of 2.16%–6.80% for each 10 μg/m3 increase of PM2.5, while thyrotropin-releasing hormone, glutathione, and phosphatidylethanolamine related to energy metabolism and oxidative stress, and phospholipid metabolism were increased in the range of 2.95%–4.90% for each 10 μg/m3 increase of PM2.5. This longitudinal study suggests that higher PM2.5 exposure may induce perturbations in serum metabolic signaling related to oxidative stress and inflammation, and males may be more prone to these metabolic perturbations.
Shu Huan; Shuna Jin; Hongxiu Liu; Wei Xia; Gaodao Liang; Shunqing Xu; Xingjie Fang; Chunhui Li; Qianqian Wang; Xiaojie Sun; Yuanyuan Li. Fine particulate matter exposure and perturbation of serum metabolome: A longitudinal study in Baoding, China. Chemosphere 2021, 276, 130102 .
AMA StyleShu Huan, Shuna Jin, Hongxiu Liu, Wei Xia, Gaodao Liang, Shunqing Xu, Xingjie Fang, Chunhui Li, Qianqian Wang, Xiaojie Sun, Yuanyuan Li. Fine particulate matter exposure and perturbation of serum metabolome: A longitudinal study in Baoding, China. Chemosphere. 2021; 276 ():130102.
Chicago/Turabian StyleShu Huan; Shuna Jin; Hongxiu Liu; Wei Xia; Gaodao Liang; Shunqing Xu; Xingjie Fang; Chunhui Li; Qianqian Wang; Xiaojie Sun; Yuanyuan Li. 2021. "Fine particulate matter exposure and perturbation of serum metabolome: A longitudinal study in Baoding, China." Chemosphere 276, no. : 130102.
Objectives This study aimed to evaluate whether PM2.5 exposure in a highly polluted area (>100 µg/m3) affects glucose and lipid metabolism in healthy adults. Methods We recruited 110 healthy adults in Baoding city, Hebei, China, and followed them up between 2017 and 2018. Personal air samplers were used to monitor personal PM2.5 levels. Eight glucose and lipid metabolism parameters were quantified. We performed the linear mixed-effect models to investigate the relationships between PM2.5 and glucose and lipid metabolism parameters. Stratified analyses were further performed according to sex and body mass index (BMI). Results The concentration of PM2.5 was the highest in spring, with a median of 232 μg/m3 and the lowest in autumn (139 μg/m3). After adjusting for potential confounders, we found that for each twofold increase in PM2.5, the median of insulin concentration decreased by 5.89% (95% CI −10.91% to −0.58%; p<0.05), and ox-LDL increased by 6.43% (95% CI 2.21% to 10.82%; p<0.05). Stratified analyses indicated that the associations were more pronounced in females, overweight and obese participants. Conclusions Exposure to high PM2.5 may have deleterious effects on glucose and lipid metabolism. Females, overweight and obese participants are more vulnerable.
Jingyi Qin; Wei Xia; Gaodao Liang; Shunqing Xu; Xiuge Zhao; Danlu Wang; Xiaojie Sun; Yuanyuan Li; Hongxiu Liu. Association of fine particulate matter with glucose and lipid metabolism: a longitudinal study in young adults. Occupational and Environmental Medicine 2021, 78, 448 -453.
AMA StyleJingyi Qin, Wei Xia, Gaodao Liang, Shunqing Xu, Xiuge Zhao, Danlu Wang, Xiaojie Sun, Yuanyuan Li, Hongxiu Liu. Association of fine particulate matter with glucose and lipid metabolism: a longitudinal study in young adults. Occupational and Environmental Medicine. 2021; 78 (6):448-453.
Chicago/Turabian StyleJingyi Qin; Wei Xia; Gaodao Liang; Shunqing Xu; Xiuge Zhao; Danlu Wang; Xiaojie Sun; Yuanyuan Li; Hongxiu Liu. 2021. "Association of fine particulate matter with glucose and lipid metabolism: a longitudinal study in young adults." Occupational and Environmental Medicine 78, no. 6: 448-453.
Prenatal vanadium exposure is reported to be associated with restricted fetal growth and adverse birth outcomes. However, trimester-specific vanadium exposure in relation to early-childhood growth still remains unclear. A total of 1873 Chinese mother-infant pairs from whom a complete series of maternal urinary samples were collected over three stages of pregnancy were included from 2014 to 2016. The urinary concentrations of vanadium were analyzed. Children’s anthropometric parameters were measured at birth, 6, 12 and 24 months. In boys, each doubling increase in vanadium concentrations at middle pregnancy was inversely associated with weight-for-length [− 9.07% (− 17.21%, − 0.93%)] and BMI z-score [− 9.66% (− 18.05%, − 1.28%)] at 24 months. Moreover, vanadium exposure at late pregnancy was negatively associated with weight [− 9.85% (− 16.42%, − 3.28%)], weight-for-length [− 11.00% (− 18.40%, − 3.60%)], and BMI z-scores [− 11.05% (− 18.67%, − 3.42%)] at 24 months in boys. However, the negative associations were not observed in girls, and we found evidence for sex difference (FDR p for interaction = 0.01, 0.01 and 0.03 for weight, weight-for-length and BMI z-scores, respectively). Prenatal vanadium exposure may have an adverse effect on early-childhood growth, and the middle and late pregnancy could be windows of vulnerability for the adverse effects of vanadium exposure on growth development.
Chunhui Li; Chuansha Wu; Jingjing Zhang; Yuanyuan Li; Bin Zhang; Aifen Zhou; Wenyu Liu; Zhong Chen; Ruizhen Li; Zhongqiang Cao; Wei Xia; Shunqing Xu. Associations of prenatal exposure to vanadium with early-childhood growth: A prospective prenatal cohort study. Journal of Hazardous Materials 2021, 411, 125102 .
AMA StyleChunhui Li, Chuansha Wu, Jingjing Zhang, Yuanyuan Li, Bin Zhang, Aifen Zhou, Wenyu Liu, Zhong Chen, Ruizhen Li, Zhongqiang Cao, Wei Xia, Shunqing Xu. Associations of prenatal exposure to vanadium with early-childhood growth: A prospective prenatal cohort study. Journal of Hazardous Materials. 2021; 411 ():125102.
Chicago/Turabian StyleChunhui Li; Chuansha Wu; Jingjing Zhang; Yuanyuan Li; Bin Zhang; Aifen Zhou; Wenyu Liu; Zhong Chen; Ruizhen Li; Zhongqiang Cao; Wei Xia; Shunqing Xu. 2021. "Associations of prenatal exposure to vanadium with early-childhood growth: A prospective prenatal cohort study." Journal of Hazardous Materials 411, no. : 125102.
Background: Thallium is a widely known toxic heavy metal that has been reported have embryo toxicity.Objective: We aimed to investigate the relationship of prenatal thallium exposure with neonatal telomere length.Methods: A total of 746 mother-newborn pairs were recruited from Wuhan Children Hospital between November 2013 and March 2015 in Wuhan City, China. Maternal thallium exposure levels were measured in spot urine samples collected during the three trimesters and during hospital delivery using inductively coupled plasma mass spectrometry. Neonatal relative telomere length (rTL) was measured by a real-time quantitative polymerase chain reaction assay in cord blood. Multiple informant models were used to evaluate the association of maternal thallium exposure with neonatal rTL.Results: After adjustment for multiple potential confounders, each 25% incremental increase of maternal thallium exposure, measured in urine samples collected during hospital delivery, was associated with a 1.85% shortened neonatal rTL (95% CI: -3.62%, -0.05%; P = 0.044). Similarly, mothers in the highest quartile of urinary thallium exposure had a 11.74% (95% CI: -21.57%, -0.68%; P = 0.038) shorter cord blood leukocyte rTL than those in the lowest quartile. However, no significant association was found between neonatal rTL and maternal thallium exposure measured in urine samples collected during the three trimesters of pregnancy.Conclusions: This study reveals that prenatal thallium exposure was related to shortened neonatal telomere length in Chinese population, pointing to the important role of thallium exposure in accelerating biological aging.
Mingyang Wu; Lulin Wang; Lulu Song; Bingqing Liu; Yunyun Liu; Jianing Bi; Qing Liu; Kai Chen; Yuanyuan Li; Wei Xia; Shunqing Xu; Zhongqiang Cao; Aifen Zhou; Yaohua Tian; Youjie Wang. The association between prenatal exposure to thallium and shortened telomere length of newborns. Chemosphere 2020, 265, 129025 .
AMA StyleMingyang Wu, Lulin Wang, Lulu Song, Bingqing Liu, Yunyun Liu, Jianing Bi, Qing Liu, Kai Chen, Yuanyuan Li, Wei Xia, Shunqing Xu, Zhongqiang Cao, Aifen Zhou, Yaohua Tian, Youjie Wang. The association between prenatal exposure to thallium and shortened telomere length of newborns. Chemosphere. 2020; 265 ():129025.
Chicago/Turabian StyleMingyang Wu; Lulin Wang; Lulu Song; Bingqing Liu; Yunyun Liu; Jianing Bi; Qing Liu; Kai Chen; Yuanyuan Li; Wei Xia; Shunqing Xu; Zhongqiang Cao; Aifen Zhou; Yaohua Tian; Youjie Wang. 2020. "The association between prenatal exposure to thallium and shortened telomere length of newborns." Chemosphere 265, no. : 129025.
Neonicotinoid insecticides (NNIs) are the most extensively used insecticides worldwide, threatening ecosystem and human health. However, nationwide studies of NNIs and their metabolites in drinking water are limited. In order to characterize the contamination status of NNIs in drinking water throughout China, we collected 884 drinking water samples including 789 tap water and 95 groundwater samples from 32 provinces (covering seven regions of mainland China: south, central, east, north, northeast, northwest, and southwest) and Hong Kong. Ten NNIs and six of their main metabolites were determined in the water samples. The relative potency factor method was used to assess the cumulative concentrations of NNIs and their metabolites (imidacloprid-equivalent total NNIs, IMIeq) based on the chronic reference doses (cRfDs) of the NNIs or the toxic effects of the mataboilites. The IMIeq varied among the studied regions, with a median concentration of 24.5 ng/L and a maximum concentration of 8,622 ng/L. The predominant NNIs in drinking water were acetamiprid (ACE) and imidacloprid (IMI). Compared with tap water derived from groundwater, much higher concentrations of IMIeq and NNIs were found in tap water derived from surface water. Different concentrations and patterns of NNIs in drinking water were observed in different regions, provinces, and capital cities, mainly due to regional and provincial differences in crop types and volumes of pesticide usage. The concentrations of NNIs in the drinking water of provincial capitals and small/medium cities were higher than the concentrations in rural areas. The estimated daily intake (EDI) of IMIeq was at least two orders of magnitude lower than the cRfD of IMI, while the NNIs in 16 drinking water samples exceeded the acceptable value (100 ng/L) recommended by the European Union. This study provided a nationwide profile of the occurrence of NNIs and their metabolites in the drinking water of China and the associated potential cumulative human health risks, taking into account of the toxicity differences between NNIs and their metabolites.
Gaga Mahai; Yanjian Wan; Wei Xia; Aizhen Wang; Lisha Shi; Xi Qian; Zhenyu He; Shunqing Xu. A nationwide study of occurrence and exposure assessment of neonicotinoid insecticides and their metabolites in drinking water of China. Water Research 2020, 189, 116630 .
AMA StyleGaga Mahai, Yanjian Wan, Wei Xia, Aizhen Wang, Lisha Shi, Xi Qian, Zhenyu He, Shunqing Xu. A nationwide study of occurrence and exposure assessment of neonicotinoid insecticides and their metabolites in drinking water of China. Water Research. 2020; 189 ():116630.
Chicago/Turabian StyleGaga Mahai; Yanjian Wan; Wei Xia; Aizhen Wang; Lisha Shi; Xi Qian; Zhenyu He; Shunqing Xu. 2020. "A nationwide study of occurrence and exposure assessment of neonicotinoid insecticides and their metabolites in drinking water of China." Water Research 189, no. : 116630.
Studies have shown that lead exposure affected the immune function, but few studies have examined the relationships between in utero lead exposure, a sensitive period that is important for immune development, and later immune responses. To investigate the effects of prenatal and childhood lead exposure on the preschool-aged children’s immune responses, a prospective birth cohort study was established in Wuhan, China, in which lead concentrations were analyzed in maternal urine during the third trimester and in plasma samples from children aged about 3 years. We assessed immune responses by measuring immune cytokines in the children's plasma (n = 326) and peripheral blood T lymphocyte subsets (n = 394) at 3 years of age. Each unit increase in maternal urinary lead concentration (μg/g creatinine) was associated with reduced IL-10 (β = −5.93%, 95%CI: −11.82%, −0.03%) and reduced IL-4 levels (β = −5.62%, 95%CI: −10.44%, −0.80%). Lead in children’s plasma (μg/L) was associated with significant increase in TNF-α (β = 10.78%, 95%CI: 3.97%, 17.59%). No statistically significant relationship of childhood lead exposure with T lymphocyte subsets was observed. The study suggested prenatal and childhood lead exposure was associated with changes in preschool children’s plasma cytokine levels.
Meng Wang; Wei Xia; Qiang Zeng; Wenxin Zhang; Xi Qian; Shuangshuang Bao; Aifen Zhou; Yuanyuan Li; Shunqing Xu. Associations between prenatal and postnatal lead exposure and preschool children humoral and cellular immune responses. Ecotoxicology and Environmental Safety 2020, 207, 111536 .
AMA StyleMeng Wang, Wei Xia, Qiang Zeng, Wenxin Zhang, Xi Qian, Shuangshuang Bao, Aifen Zhou, Yuanyuan Li, Shunqing Xu. Associations between prenatal and postnatal lead exposure and preschool children humoral and cellular immune responses. Ecotoxicology and Environmental Safety. 2020; 207 ():111536.
Chicago/Turabian StyleMeng Wang; Wei Xia; Qiang Zeng; Wenxin Zhang; Xi Qian; Shuangshuang Bao; Aifen Zhou; Yuanyuan Li; Shunqing Xu. 2020. "Associations between prenatal and postnatal lead exposure and preschool children humoral and cellular immune responses." Ecotoxicology and Environmental Safety 207, no. : 111536.
Increasing evidence shows that exposure to per- and polyfluoroalkyl substances (PFASs), common and persistent anthropogenic pollutants, may affect glucose homeostasis. However, data is limited for pregnant women, and it is less clear how novel fluorinated pollutants affect glucose homeostasis during pregnancy. Our goal was to investigate the relationships of exposure to13 PFASs including some novel fluorinated pollutants with blood glucose in 874 Chinese pregnant women from the general population. We measured blood glucose following an oral glucose tolerance test (OGTT) in the second trimester and quantified PFAS concentrations in umbilical cord blood. The associations of PFAS exposure with fasting, 1-h OGTT and 2-h OGTT glucose were examined using the general linear regression model. For every doubling of perfluorobutane sulfonate (PFBS), a short-chain PFAS, the 1-h and 2-h OGTT blood glucose increased 0.09 mmol/L (β = 0.09, 95%CI: 0.02, 0.17) and 0.07 mmol/L (β = 0.07, 95%CI: 0.01, 0.13), respectively. In addition, perfluoroheptanoate (PFHpA), an alternative of perfluorooctanoate (PFOA), was positively associated with fasting glucose (β = 0.07, 95%CI: 0.02, 0.13; high vs low). Higher levels of PFAS exposure were related to increased blood glucose in pregnant women, indicating PFAS exposure may impair glucose homeostasis during pregnancy.
Juxiao Li; Jingzhi Yao; Wei Xia; Jiayin Dai; Hongxiu Liu; Yitao Pan; Shunqing Xu; Shi Lu; Shuna Jin; Yuanyuan Li; Xiaojie Sun; Bin Zhang; Tongzhang Zheng; Yangqian Jiang; Tao Jing. Association between exposure to per- and polyfluoroalkyl substances and blood glucose in pregnant women. International Journal of Hygiene and Environmental Health 2020, 230, 113596 .
AMA StyleJuxiao Li, Jingzhi Yao, Wei Xia, Jiayin Dai, Hongxiu Liu, Yitao Pan, Shunqing Xu, Shi Lu, Shuna Jin, Yuanyuan Li, Xiaojie Sun, Bin Zhang, Tongzhang Zheng, Yangqian Jiang, Tao Jing. Association between exposure to per- and polyfluoroalkyl substances and blood glucose in pregnant women. International Journal of Hygiene and Environmental Health. 2020; 230 ():113596.
Chicago/Turabian StyleJuxiao Li; Jingzhi Yao; Wei Xia; Jiayin Dai; Hongxiu Liu; Yitao Pan; Shunqing Xu; Shi Lu; Shuna Jin; Yuanyuan Li; Xiaojie Sun; Bin Zhang; Tongzhang Zheng; Yangqian Jiang; Tao Jing. 2020. "Association between exposure to per- and polyfluoroalkyl substances and blood glucose in pregnant women." International Journal of Hygiene and Environmental Health 230, no. : 113596.
Previous studies on environmental pollutant exposure during pregnancy have mostly focused on individual chemical substances or single urine measurements. Thus, our understanding of the potential cumulative or interactive effects of exposure is limited. We aimed to ascertain the characteristics and predictors of exposure to environmental chemicals over three trimesters among pregnant women. We measured the concentrations of 34 chemicals in spot urine samples provided by 745 participants in their early, middle, and late pregnancy. We calculated Spearman correlation coefficients (SCC) between exposure levels of multiple chemicals in each trimester. K-means clustering and principal components analysis (PCA) were applied to classify the populations and reduce data dimensionality. We used generalized linear models (GLM) to confirm predictors of each cluster and principal component. SCC showed that the correlations of chemical concentrations from the same classes were higher than those among concentrations of different classes. Cluster analysis categorized participants into three clusters, and each cluster represented different chemical concentrations. We restricted the principal components to six, which explained more than 50% of the data variations. Several physiological, socio-demographic factors, and behavior patterns were related to different clusters and principal components. Distinct exposure patterns and dominant exposure components of multiple environmental chemicals among pregnant women might help research the potential health effects of exposure to chemical mixtures and develop relevant public health interventions.
Huan Chen; Wenxin Zhang; Yanqiu Zhou; Jiufeng Li; Hongzhi Zhao; Shunqing Xu; Wei Xia; Zongwei Cai; Yuanyuan Li. Characteristics of exposure to multiple environmental chemicals among pregnant women in Wuhan, China. Science of The Total Environment 2020, 754, 142167 .
AMA StyleHuan Chen, Wenxin Zhang, Yanqiu Zhou, Jiufeng Li, Hongzhi Zhao, Shunqing Xu, Wei Xia, Zongwei Cai, Yuanyuan Li. Characteristics of exposure to multiple environmental chemicals among pregnant women in Wuhan, China. Science of The Total Environment. 2020; 754 ():142167.
Chicago/Turabian StyleHuan Chen; Wenxin Zhang; Yanqiu Zhou; Jiufeng Li; Hongzhi Zhao; Shunqing Xu; Wei Xia; Zongwei Cai; Yuanyuan Li. 2020. "Characteristics of exposure to multiple environmental chemicals among pregnant women in Wuhan, China." Science of The Total Environment 754, no. : 142167.
Objective This study aimed to estimate the associations of gestational weight gain rate (GWGR) during different trimesters with offspring growth and overweight/obesity risk. Methods The study included 4,807 mother‐infant pairs enrolled in Wuhan, China. GWGR in each trimester was used as a continuous and a categorical variable to estimate the associations with offspring BMI z score (ZBMI) and overweight/obesity risk between 0 and 2 years. Results Greater GWGR (per 0.2 kg/wk) in the first, second, and third trimester was positively associated with offspring ZBMI across birth to 2 years old (β 0.06 [95% CI: 0.04‐0.09], β 0.13 [95% CI: 0.09‐0.16], and β 0.04 [95% CI: 0.02‐0.07], respectively). Excessive GWGR in the first trimester (≥ 0.30 kg/wk) was associated with an odds ratio (OR) of 1.58 (95% CI: 1.18‐2.13) and 1.37 (95% CI: 1.11‐1.71) for macrosomia and 2‐year overweight/obesity, respectively. Excessive GWGR in the second trimester was associated with an OR of 2.09 (95% CI: 1.42‐3.08), 1.21 (95% CI: 1.02‐1.43), and 1.48 (95% CI: 1.15‐1.90) for macrosomia, 1‐year, and 2‐year overweight/obesity, respectively. Excessive GWGR in the third trimester was associated with an OR of 1.91 (95% CI: 1.27‐2.86) and 1.32 (95% CI: 1.02‐1.72) for macrosomia and 2‐year overweight/obesity, respectively. Conclusions Excessive GWGR in each trimester was positively associated with offspring ZBMI and early‐childhood overweight/obesity risk.
Xin Xiong; Wei Xia; Yuanyuan Li; Shunqing Xu; Yaqi Zhang. Associations of Gestational Weight Gain Rate During Different Trimesters with Early‐Childhood Body Mass Index and Risk of Obesity. Obesity 2020, 28, 1941 -1950.
AMA StyleXin Xiong, Wei Xia, Yuanyuan Li, Shunqing Xu, Yaqi Zhang. Associations of Gestational Weight Gain Rate During Different Trimesters with Early‐Childhood Body Mass Index and Risk of Obesity. Obesity. 2020; 28 (10):1941-1950.
Chicago/Turabian StyleXin Xiong; Wei Xia; Yuanyuan Li; Shunqing Xu; Yaqi Zhang. 2020. "Associations of Gestational Weight Gain Rate During Different Trimesters with Early‐Childhood Body Mass Index and Risk of Obesity." Obesity 28, no. 10: 1941-1950.
No known data are available regarding the occurrence of fipronil (FP) in indoor dust in China, despite the fact that it is an emerging insecticide that is used extensively. In this study, FP and its derivatives (FPs), including fipronil sulfone (FP-SFO), fipronil sulfide, fipronil desulfinyl, and fipronil amide, were determined in indoor dust samples (n = 436) collected from three different cities in China between 2016 and 2019, namely Shenzhen (February and September 2019), Wuhan (October 2016, October 2018, and August 2019), and Taiyuan (October 2016), located in south, central, and north China, respectively. FP and FP-SFO were the major target analytes detected in all dust samples, accounting for approximately 68.6–90.1% of the cumulative concentration of FPs (ΣFPs). The ΣFPs values for the dust samples ranged from not detected (ND) to 33.6 μg/g (median ± median absolute deviation [MAD]: 7.12 ± 6.44 ng/g), with a detection frequency of 95.6%. The median value of the ΣFPs of the dust samples collected from Shenzhen (22.6 ± 15.6 ng/g) was higher than that found in the dust samples collected in Taiyuan 2016 (1.87 ± 1.65 ng/g) and Wuhan (6.43 ± 5.62 ng/g). Significantly higher ΣFPs were observed in the dust samples collected in urban areas than in the rural areas of Taiyuan and Wuhan. Furthermore, an increasing trend of FP (from 2016 to 2018) in the rural areas of Wuhan, and a seasonal variation (summer > autumn) in FP, FP-SFO, and ΣFPs in the dust samples from urban areas of Wuhan were observed. The estimated daily intake of FPs via dust ingestion for people in Shenzhen was approximately 12 times higher than in Taiyuan based on the samples analyzed. This is the first study to describe the occurrence and spatiotemporal variations of FPs in indoor dust in China.
Lisha Shi; Ying Jiang; Yanjian Wan; Juan Huang; Qianqian Meng; Zhenyu He; Shunqing Xu; Wei Xia. Occurrence of the insecticide fipronil and its degradates in indoor dust from South, Central, and North China. Science of The Total Environment 2020, 741, 140110 .
AMA StyleLisha Shi, Ying Jiang, Yanjian Wan, Juan Huang, Qianqian Meng, Zhenyu He, Shunqing Xu, Wei Xia. Occurrence of the insecticide fipronil and its degradates in indoor dust from South, Central, and North China. Science of The Total Environment. 2020; 741 ():140110.
Chicago/Turabian StyleLisha Shi; Ying Jiang; Yanjian Wan; Juan Huang; Qianqian Meng; Zhenyu He; Shunqing Xu; Wei Xia. 2020. "Occurrence of the insecticide fipronil and its degradates in indoor dust from South, Central, and North China." Science of The Total Environment 741, no. : 140110.
The presence of benzotriazoles and benzothiazoles (BTs) in maternal urine and amniotic fluid indicated the widespread fetal exposure to the contaminants. We investigated the associations of prenatal BTs exposure with fetal and birth size and explored the window of susceptibility. Participants consisted of 856 mother-infant pairs drawn from a prospective birth cohort between 2014 and 2015 in Wuhan, China. Prenatal BTs exposure were measured in multiple urine samples collected across three trimesters. We observed positive associations between prenatal exposure to specific BTs (e.g., 1-H-benzotriazole, 1-hydroxy-benzotriazole and 2-amino-benzothiazole) and femur length (FL) and birth length z-scores among girls. In boys, a 2-fold increase of averaged concentration of urinary benzothiazole (BTH) was associated with decrement in FL (β = -0.068, p < 0.001) and birth length (β = -0.055, p = 0.005) z-scores. Further analysis indicated that the negative associations between urinary concentrations of BTH and birth length z-score among boys were observed at exposure measurement in 25–35 gestational weeks. This study reported the associations between prenatal exposure to BTs and fetal and birth size, suggests the associations maybe in a sex-specific manner and the window of exposure may influence susceptibility. These findings require replication in future research.
Yanqiu Zhou; Ying Li; Shunqing Xu; Jiaqiang Liao; Hongna Zhang; Jiufeng Li; Yanjun Hong; Wei Xia; Zongwei Cai. Prenatal exposure to benzotraizoles and benzothiazoles in relation to fetal and birth size: A longitudinal study. Journal of Hazardous Materials 2020, 398, 122828 .
AMA StyleYanqiu Zhou, Ying Li, Shunqing Xu, Jiaqiang Liao, Hongna Zhang, Jiufeng Li, Yanjun Hong, Wei Xia, Zongwei Cai. Prenatal exposure to benzotraizoles and benzothiazoles in relation to fetal and birth size: A longitudinal study. Journal of Hazardous Materials. 2020; 398 ():122828.
Chicago/Turabian StyleYanqiu Zhou; Ying Li; Shunqing Xu; Jiaqiang Liao; Hongna Zhang; Jiufeng Li; Yanjun Hong; Wei Xia; Zongwei Cai. 2020. "Prenatal exposure to benzotraizoles and benzothiazoles in relation to fetal and birth size: A longitudinal study." Journal of Hazardous Materials 398, no. : 122828.