Skin has a preventive role against any damage raised by harmful microorganisms and physical and chemical assaults from the external environment that could affect the body’s internal organs. Dermis represents the main section of the skin, and its contribution to skin physiology is critical due to its diverse cellularity, vasculature, and release of molecular mediators involved in the extracellular matrix maintenance and modulation of the immune response. Skin structure and complexity limit the transport of substances, promoting the study of different types of nanoparticles that penetrate the skin layers under different mechanisms intended for skin illness treatments and dermo-cosmetic applications. In this work, we present a detailed morphological description of the dermis in terms of its structures and resident cells. Furthermore, we analyze the role of the dermis in regulating skin homeostasis and its alterations in pathophysiological conditions, highlighting its potential as a therapeutic target. Additionally, we describe the use of nanoparticles for skin illness treatments focused on dermis release and promote the use of metal-organic frameworks (MOFs) as an integrative strategy for skin treatments.

Instilling segregated cationic and lipophilic domains with an angular disposition in a trehalose‐based trifaceted macrocyclic scaffold allows engineering patchy molecular nanoparticles leveraging directional interactions that emulate those controlling self‐assembling processes in viral capsids. The resulting trilobular amphiphilic derivatives, featuring a Mickey Mouse architecture, can electrostatically interact with plasmid DNA (pDNA) and further engage in hydrophobic contacts to promote condensation into transfectious nanocomplexes. Notably, the topology and internal structure of the cyclooligosaccharide/pDNA co‐assemblies can be molded by fine‐tuning the valency and characteristics of the cationic and lipophilic patches, which strongly impacts the transfection efficacy in vitro and in vivo. Outstanding organ selectivities can then be programmed with no need of incorporating a biorecognizable motif in the formulation. The results provide a versatile strategy for the construction of fully synthetic and perfectly monodisperse nonviral gene delivery systems uniquely suited for optimization schemes by making cyclooligosaccharide patchiness the focus.

The clinical utility of the anticancer drug camptothecin (CPT) is limited by its poor aqueous solubility and instability in the bloodstream, hindering bioavailability and efficacy. This study explores the complexation of CPT with carboxymethyl-beta-cyclodextrin (cmβCD) to overcome these limitations. Fluorescence spectroscopy and molecular modeling demonstrated 1:1 inclusion complexes, with stability constants governed by electrostatic interactions that were inversely correlated with pH. To validate this effect, a cationic amino-beta-cyclodextrin (amβCD) was used as a mechanistic control, revealing that Coulombic forces significantly modulate binding strength and stoichiometry. Crucially, cmβCD enhanced CPT solubility by up to 11-fold at 14 × 10⁻³ moldm⁻³, enabling a 385-fold increase in drug loading into liposomal carriers compared to the cyclodextrin-free system. Fluorescence-based release studies indicated high liposomal stability at physiological pH and partial CPT release under acidic conditions. Furthermore, CPT-loaded liposomes demonstrated cytotoxicity against cancer cell lines, particularly BT-474, with IC₅₀ values generally comparable to or slightly higher than those of free CPT and the CPT:cmβCD complex, likely due to the distinct lysosomal cellular uptake pathway. This work highlights cmβCD complexation as a promising strategy to enhance CPT solubility and liposomal loading for improved drug delivery.

The development of polymers capable of efficient chemical recycling under mild and solvent-free conditions remains a major challenge toward a sustainable circular plastics economy. Herein, we report a molecular design strategy that enables low-temperature, solvent-free depolymerization of poly(methyl methacrylate) (PMMA) through the incorporation of anthracene-based weak links within the polymer backbone. A series of well-defined PMMA architectures were synthesized via atom transfer radical polymerization (ATRP) using tailored anthracene-derived initiators, allowing precise control over the position and connectivity of the functional unit.We demonstrate that the introduction of aryl–methylene (benzyl, Bn: ArCH₂–) linkages significantly reduces the thermal stability of PMMA, triggering efficient unzipping under bulk, solvent-free conditions at temperatures as low as 165–195 °C, well below those required for conventional PMMA (300–400 °C). Thermogravimetric analysis and NMR spectroscopy confirm the recovery of methyl methacrylate (MMA) monomer, supporting a closed-loop recycling process. Density functional theory (DFT) calculations reveal that the reduced bond dissociation energy of the ArCH₂– linkage facilitates homolytic cleavage by generating stabilized radicals. This thermodynamic advantage effectively lowers the thermal threshold required to trigger the sequential unzipping depolymerization pathway.Importantly, the absence of solvent simplifies processing and enhances the sustainability of the PMMA, while the incorporation of anthracene preserves its characteristic photophysical properties, yielding multifunctional polymer systems with potential in advanced photonic applications. This work establishes a versatile platform for encoding cleavable units into vinyl polymers, enabling efficient solvent-free chemical recycling.