Vegetation classification has always been the focus of remote sensing applications, especially for tropical regions with fragmented terrain, cloudy and rainy climates, and dense vegetation. How to effectively classify vegetation in tropical regions by using multi-spectral remote sensing with high resolution and red-edge spectrum needs to be further verified. Based on the experiment in Wenchang, Hainan, China, which is located in the tropical monsoon region, and combined with the ZY-1 02D 2.5 m fused images in January, March, July, and August, this paper discusses whether NDVI and four red-edge vegetation indices (VIs), CIre, NDVIre, MCARI, and TCARI, can promote vegetation classification and reduce the saturation. The results show that the schemes with the highest classification accuracies in all phases are those in which the red-edge VIs are involved, which suggests that the red-edge VIs can effectively contribute to the classification of vegetation. The maximum accuracy of the single phase is 86%, and the combined accuracy of the four phases can be improved to 92%. It has also been found that CIre and NDVIre do not reach saturation as easily as NDVI and MCARI in July and August, and their ability to enhance the separability between different vegetation types is superior to that of TCARI. In general, red-edge VIs can effectively promote vegetation classification in tropical monsoon regions, and red-edge VIs, such as CIre and NDVIre, have an anti-saturation performance, which can slow down the confusion between different vegetation types due to saturation.