In the context of global warming, rising air temperatures are increasing evapotranspiration (${\mathrm{ET}}_{\mathrm{c}}$) in all agricultural crops, including rice, a staple food worldwide. Simultaneously, the occurrence of droughts is reducing water availability, affecting traditional irrigation methods for rice cultivation (flood irrigation). The objective of this study was to determine ${\mathrm{ET}}_{\mathrm{c}}$ (water use) and yield performance in rice crop under different irrigation regimes: treatments with continuous flood irrigation (CF) and irrigations with alternating wetting and drying (${\mathrm{A}\mathrm{W}\mathrm{D}}_5$, ${\mathrm{A}\mathrm{W}\mathrm{D}}_{10}$, and ${\mathrm{A}\mathrm{W}\mathrm{D}}_{20}$) in an experimental area in INIA–Vista Florida. Water balance, rice physiological data, and yield were measured in the field, and local weather data and thermal and multispectral images were collected with a meteorological station and a UAV (a total of 13 flights). ${\mathrm{ET}}_{\mathrm{c}}$ values obtained by applying the METRIC^TM (Mapping Evapotranspiration at High Resolution using Internalized Calibration) energy balance model ranged from 2.4 to 8.9 mm d⁻¹ for the AWD and CF irrigation regimes. In addition, ${\mathrm{ET}}_{\mathrm{c}}$ was estimated by a water balance using the AquaCrop model, previously parameterized with RGB image data and field weather data, soil, irrigation water, and crops, obtaining values between 4.3 and 7.1 mm d⁻¹ for the AWD and CF irrigation regimes. The results indicated that AWD irrigation allows for water savings of 27 to 28%, although it entails a yield reduction of from 2 to 15%, which translates into an increase in water use efficiency (WUE) of from 18 to 36%, allowing for optimizing water use and improving irrigation management.