Domenico D'Ugo

Prof. Domenico D'Ugo

ESSO - European Society of Surgical Oncology
orcid

Research Focus & Metrics

Academic Career Length

18Years (2009-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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7 April 2020 in World Journal of Emergency Surgery
Verified
Journal Article
Open access
PDF file
ACand Federico Coccolini
and Federico Coccolini
Gennaro PerroneGennaro Perrone
Gennaro Perrone
MCMassimo Chiarugi
Massimo Chiarugi
FMFrancesco Di Marzo
Francesco Di Marzo
LALuca Ansaloni
Luca Ansaloni
Fausto CatenaFausto Catena
Fausto Catena
The current COVID-19 pandemic underlines the importance of a mindful utilization of financial and human resources. Preserving resources and manpower is paramount in healthcare. It is important to ensure the ability of surgeons and specialized professionals to function through the pandemic. A conscious effort should be made to minimize infection in this sector. A high mortality rate within this group would be detrimental.This manuscript is the result of a collaboration between the major Italian surgical and anesthesiologic societies: ACOI, SIC, SICUT, SICO, SICG, SIFIPAC, SICE, and SIAARTI. We aim to describe recommended clinical pathways for COVID-19-positive patients requiring acute non-deferrable surgical care. All hospitals should organize dedicated protocols and workforce training as part of the effort to face the current pandemic.

24 February 2023 in European Journal of Cancer
Verified
Journal Article
Open access
TKTiuri E. Kroese
Tiuri E. Kroese
HLHanneke Van Laarhoven
Hanneke Van Laarhoven
SSSebastian F. Schoppman
Sebastian F. Schoppman
PDPieter R.A.J. Deseyne
Pieter R.A.J. Deseyne
ECEric van Cutsem
Eric van Cutsem
KRKarol Rawicz-Pruszyński
Karol Rawicz-Pruszyński
Local treatment improves the outcomes for oligometastatic disease (OMD, i.e. an intermediate state between locoregional and widespread disseminated disease). However, consensus about the definition, diagnosis and treatment of oligometastatic oesophagogastric cancer is lacking. The aim of this study was to develop a multidisciplinary European consensus statement on the definition, diagnosis and treatment of oligometastatic oesophagogastric cancer. In total, 65 specialists in the multidisciplinary treatment for oesophagogastric cancer from 49 expert centres across 16 European countries were requested to participate in this Delphi study. The consensus finding process consisted of a starting meeting, 2 online Delphi questionnaire rounds and an online consensus meeting. Input for Delphi questionnaires consisted of (1) a systematic review on definitions of oligometastatic oesophagogastric cancer and (2) a discussion of real-life clinical cases by multidisciplinary teams. Experts were asked to score each statement on a 5-point Likert scale. The agreement was scored to be either absent/poor (2 years, either upfront local treatment or systemic treatment followed by restaging was considered as treatment (fair agreement). The OMEC project has resulted in a multidisciplinary European consensus statement for the definition, diagnosis and treatment of oligometastatic oesophagogastric adenocarcinoma and squamous cell cancer. This can be used to standardise inclusion criteria for future clinical trials.

5 February 2022 in European Journal of Cancer
Verified
Journal Article
Open access
TKTiuri E. Kroese
Tiuri E. Kroese
RHRichard van Hillegersberg
Richard van Hillegersberg
SSSebastian Schoppmann
Sebastian Schoppmann
PDPieter R.A.J. Deseyne
Pieter R.A.J. Deseyne
PNPhilippe Nafteux
Philippe Nafteux
ICIrene Chong
Irene Chong

9 August 2023 in Annals of Surgery
Verified
Journal Article
Closed access
KSKatarzyna Sedlak
Katarzyna Sedlak
KRKarol Rawicz-Pruszyński
Karol Rawicz-Pruszyński
Radosław MlakRadosław Mlak
Radosław Mlak
JSJohanna Van Sandick
Johanna Van Sandick
SGSuzanne S. Gisbertz
Suzanne S. Gisbertz
Wojciech PolkowskiWojciech Polkowski
Wojciech Polkowski
Objective: To assess the rate of textbook outcome (TO) and textbook oncological outcome (TOO) in the European population based on the GASTRODATA registry. Background: TO is a composite parameter assessing surgical quality and strongly correlates with improved overall survival. Following the standard of treatment for locally advanced gastric cancer, TOO was proposed as a quality and optimal multimodal treatment parameter. Methods: TO was achieved when all the following criteria were met: no intraoperative complications, radical resection according to the surgeon, pR0 resection, retrieval of at least 15 lymph nodes, no severe postoperative complications, no reintervention, no admission to the intensive care unit, no prolonged length of stay, no postoperative mortality and no hospital readmission. TOO was defined as TO with the addition of perioperative chemotherapy compliance. Results: Of the 2558 patients, 1700 were included in the analysis. TO was achieved in 1164 (68.5%) patients. The use of neoadjuvant chemotherapy [odds ratio (OR) = 1.33, 95% CI: 1.04–1.70] and D2 or D2+ lymphadenectomy (OR = 1.55, 95% CI: 1.15–2.10) had a positive impact on TO achievement. Older age (OR = 0.73, 95% CI: 0.54–0.94), pT3/4 (OR = 0.79, 95% CI: 0.63–0.99), ASA 3/4 (OR = 0.68, 95% CI: 0.54–0.86) and total gastrectomy (OR = 0.56, 95% CI: 0.45–0.70), had a negative impact on TO achievement. TOO was achieved in 388 (22.8%) patients. Older age (OR = 0.37, 95% CI: 0.27–0.53), pT3 or pT4 (OR = 0.52, 95% CI: 0.39–0.69), and ASA 3 or 4 (OR = 0.58, 95% CI: 0.43–0.79) had a negative impact on TOO achievement. Conclusions: Despite successively improved surgical outcomes, stage‐appropriate chemotherapy in adherence to the current guidelines for multimodal treatment of gastric cancer remains poor. Further implementation of oncologic quality metrics should include greater emphasis on perioperative chemotherapy and adequate lymphadenectomy.

1 November 2021 in European Journal of Surgical Oncology
Verified
Journal Article
Open access
JHJos van der Hage
Jos van der Hage
SSsergio Sandrucci
sergio Sandrucci
RARiccardo Audisio
Riccardo Audisio
LWLynda Wyld
Lynda Wyld
TATeresa F Amaral
Teresa F Amaral
AEAne Gerda Zahl Eriksson
Ane Gerda Zahl Eriksson
Surgical oncology is a defined specialty within the European Board of Surgery within the European Union of Medical Specialists (UEMS). Variation in training and specialization still occurs across Europe. There is a need to align the core knowledge needed to fulfil the criteria across subspecialities in surgical oncology. The core curriculum, established in 2013, was developed with contributions from expert advisors from within the European Society of Surgical Oncology (ESSO), European Society for Radiotherapy and Oncology (ESTRO) and European Society of Medical Oncology (ESMO) and related subspeciality experts. The current version reiterates and updates the core curriculum structure needed for current and future candidates who plans to train for and eventually sit the European fellowship exam for the European Board of Surgery in Surgical Oncology. The content included is not intended to be exhaustive but, rather to give the candidate an idea of expectations and areas for in depth study, in addition to the practical requirements. The five elements included are: Basic principles of oncology; Disease site specific oncology; Generic clinical skills; Training recommendations, and, lastly; Eligibility for the EBSQ exam in Surgical Oncology. As evidence-based care for cancer patients evolves through research into basic science, translational research and clinical trials, the core curriculum will evolve, mature and adapt to deliver continual improvements in cancer outcomes for patients.

1 January 2018 in The American Journal of Surgery
Verified
Journal Article
Closed access
FSFrancesco Santullo
Francesco Santullo
ABAlberto Biondi
Alberto Biondi
FCFerdinando C.M. Cananzi
Ferdinando C.M. Cananzi
VFValeria Fico
Valeria Fico
FTFlavio Tirelli
Flavio Tirelli
RPRoberto Persiani
Roberto Persiani