This work highlights the structural and thermochemical differences of two modifications of the NK₁receptor antagonist aprepitant. Form I° is the stable polymorph and crystallises in the orthorhombic space groupP2₁2₁2₁ whereas the metastable form II is monoclinic (space groupP2₁). The monotropically related polymorphs show only minor differences in melting point and heat of fusion (T_fus,I = 253.6, Δ_fusH_I = 53.7 kJ mol⁻¹, T_fus,II = 253.0 °C, Δ_fusH_II = 52.4 kJ mol⁻¹) and often crystallise concomitantly. The forms exhibit a very close structural relationship based on a common 2D packing fragment, which is in fact a stack of 1D N–H⋯O hydrogen bonded ribbon chains. Forms I° and II may therefore be interpreted as two distinct stacking modes of this common 2D unit. The alternative modes are associated with slight differences in weaker intermolecular interactions. Somewhat surprisingly, the aprepitant molecule adopts almost the same conformation in the two crystal structures in spite of its potential conformational flexibility. Hirshfeld surface analysis was successfully deployed to visualise and elaborate the small differences in the molecular environments of the two polymorphs. The study emphasises the benefit of single-crystal structure data for the judgement of the phase purity and of polymorphs exhibiting only weak energetical and structural differences.

The rate of oxidation of tertiary amines by aqueous hydrogen peroxide is increased in the presence of acetonitrile due to the formation of a reactive intermediate. The active oxidant, presumably peroxyacetimidic acid, was quantified by a photometric method. Activation parameters of the acetonitrile-assisted and non-assisted oxidations are given in the temperature range 20 to 40 °C. The increased rate of the assisted oxidation is explained by the low enthalpy of activation although the entropy of activation is more negative due to a highly ordered transition state.