In this paper, delay-optimal and energy-efficient communication is studied for a single link under Markov random arrivals. We present the optimal tradeoff between delay and power over Additive White Gaussian Noise (AWGN) channels and extend the optimal tradeoff for block fading channels. Under time-correlated traffic arrivals, we develop a cross-layer solution that jointly considers the arrival rate, the queue length, and the channel state in order to minimize the average delay subject to a power constraint. For this purpose, we formulate the average delay and power problem as a Constrained Markov Decision Process (CMDP). Based on steady-state analysis for the CMDP, a Linear Programming (LP) problem is formulated to obtain the optimal delay-power tradeoff. We further show the optimal transmission strategy using a Lagrangian relaxation technique. Specifically, the optimal adaptive transmission is shown to have a threshold type of structure, where the thresholds on the queue length are presented for different transmission rates under the given arrival rates and channel states. By exploiting the result, we develop a threshold-based algorithm to efficiently obtain the optimal delay-power tradeoff. We show how a trajectory-sampling version of the proposed algorithm can be developed without the prior need of arrival statistics.

The prevalence of cardiocerebrovascular disease (CVD) is continuously increasing, and it is the leading cause of human death. Since it is difficult for physicians to screen thousands of people, high-accuracy and interpretable methods need to be presented. We developed four machine learning-based CVD classifiers (i.e., multi-layer perceptron, support vector machine, random forest, and light gradient boosting) based on the Korea National Health and Nutrition Examination Survey. We resampled and rebalanced KNHANES data using complex sampling weights such that the rebalanced dataset mimics a uniformly sampled dataset from overall population. For clear risk factor analysis, we removed multicollinearity and CVD-irrelevant variables using VIF-based filtering and the Boruta algorithm. We applied synthetic minority oversampling technique and random undersampling before ML training. We demonstrated that the proposed classifiers achieved excellent performance with AUCs over 0.853. Using Shapley value-based risk factor analysis, we identified that the most significant risk factors of CVD were age, sex, and the prevalence of hypertension. Additionally, we identified that age, hypertension, and BMI were positively correlated with CVD prevalence, while sex (female), alcohol consumption and, monthly income were negative. The results showed that the feature selection and the class balancing technique effectively improve the interpretability of models.

Despite the many comorbidities and high mortality rate in preterm infants with patent ductus arteriosus (PDA), therapeutic strategies vary depending on the clinical setting, and most studies of the related risk factors are based on small sample populations. We aimed to compare the performance of artificial intelligence (AI) analysis with that of conventional analysis to identify risk factors associated with symptomatic PDA (sPDA) in very low birth weight infants. This nationwide cohort study included 8369 very low birth weight (VLBW) infants. The participants were divided into an sPDA group and an asymptomatic PDA or spontaneously close PDA (nPDA) group. The sPDA group was further divided into treated and untreated subgroups. A total of 47 perinatal risk factors were collected and analyzed. Multiple logistic regression was used as a standard analytic tool, and five AI algorithms were used to identify the factors associated with sPDA. Combining a large database of risk factors from nationwide registries and AI techniques achieved higher accuracy and better performance of the PDA prediction tasks, and the ensemble methods showed the best performances.