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Walaa F. Alsanie
Centre of Biomedical Sciences Research (CBSR), Deanship of Scientific Research, Taif University, Taif 21944, Saudi Arabia

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Journal article
Published: 25 August 2021 in Molecules
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In isoprenaline (ISO)-induced myocardial infarcted rats, garlic oil (GO) and its main ingredient, diallyl disulfide (DADS), were examined for cardioprotective effects when used with carvedilol (CAR). GO, DADS and CAR were given to rats in their respective groups, either alone or together, with the addition of isoprenaline (3 mg/kg/day, subcutaneously) during the last 10 days of treatment. At the end of 14 days of treatment, blood samples were collected, the hearts were excised under anesthesia and weighed. Heart tissue homogenate was used to measure superoxide dismutase (SOD), catalase (CAT), and thiobarbituric acid reactive substances (TBARS). Furthermore, the serum activities of cardiac markers, including lactate dehydrogenase, creatine kinase, and cardiac troponin, were checked. Moreover, inflammatory markers including tumor necrosis factor alpha, interleukin one beta, interleukin six, and kappa bp65 subunit were assessed. Rats that received GO, DADS, and CAR exhibited a significant increase in the cardiac antioxidant enzyme activities with a simultaneous decrease in serum cardiac markers enzymes and inflammatory markers. The TBARS were significantly reduced in rats that received treatment. The addition of carvedilol to GO or DADS significantly elevated antioxidant activities and decreased the release of cardiac enzymes into blood circulation. Both DADS and GOl were almost similar in efficacy, indicating the potential role of DADS in garlic oil-mediated cardioprotection. Combining GO or DADS with CAR increased CAR’s cardioprotective impact and protected rats from developing ISO-induced myocardial infarction.

ACS Style

Syed Mohammed Basheeruddin Asdaq; Abdulhakeem S. Alamri; Walaa F. Alsanie; Majid Alhomrani. Cardioprotective Potential of Garlic Oil and Its Active Constituent, Diallyl Disulphide, in Presence of Carvedilol during Chronic Isoprenaline Injection-Mediated Myocardial Necrosis in Rats. Molecules 2021, 26, 5137 .

AMA Style

Syed Mohammed Basheeruddin Asdaq, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani. Cardioprotective Potential of Garlic Oil and Its Active Constituent, Diallyl Disulphide, in Presence of Carvedilol during Chronic Isoprenaline Injection-Mediated Myocardial Necrosis in Rats. Molecules. 2021; 26 (17):5137.

Chicago/Turabian Style

Syed Mohammed Basheeruddin Asdaq; Abdulhakeem S. Alamri; Walaa F. Alsanie; Majid Alhomrani. 2021. "Cardioprotective Potential of Garlic Oil and Its Active Constituent, Diallyl Disulphide, in Presence of Carvedilol during Chronic Isoprenaline Injection-Mediated Myocardial Necrosis in Rats." Molecules 26, no. 17: 5137.

Journal article
Published: 16 August 2021 in Agronomy
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Crop diversity through residue incorporation is the most important method for sustaining soil health. A field study was conducted over five consecutive years (2012–2017) to see the impact of residue incorporartions in Inceptisol of eastern India. The main plot treatments had five cropping systems (CS), namely, fallow−rice−rice (FRR), jute−rice−wheat (JRW), jute−rice−baby corn (JRBc), jute−rice−vegetable pea (JRGp), jute−rice−mustard−mungbean/green gram (JRMMu), which cinsisted of four sub-plots with varied nutrient and crop residue management (NCRM) levels, namely crops with no residue +75% of the recommended dose of fertilizers (RDF) (F1R0), crops with the residue of the previous crops +75% RDF (F1R1), crops with no resiude +100% RDF (F2R0), and crops with residue +100% RDF (F2R1). The highest system productivity was obtained for JRBc (15.3 Mg·ha−1), followed by JRGp (8.81 Mg·ha−1) and JRMMu (7.61 Mg·ha−1); however, the highest sustainability index was found with the JRGp cropping system (0.88), followed by JRMMu (0.82). Among the NCRMs, the highest productivity (8.78 Mg·ha−1) and sustainability index (0.83) were recorded in F2R1. Five soil parameters, namely, bulk density, available K, urease activity, dehydrogenase activity, and soil microbial biomass carbon (SMBC), were used in the minimum data-set (MDS) for the calculation of the soil quality index (SQI). The best attainment of SQI was found in the JRGp system (0.63), closely followed by the JRMMu (0.61) cropping system.

ACS Style

Mukesh Kumar; Sabyasachi Mitra; Sonali Paul Mazumdar; Bijan Majumdar; Amit Ranjan Saha; Shiv Ram Singh; Biswajit Pramanick; Ahmed Gaber; Walaa F. Alsanie; Akbar Hossain. Improvement of Soil Health and System Productivity through Crop Diversification and Residue Incorporation under Jute-Based Different Cropping Systems. Agronomy 2021, 11, 1622 .

AMA Style

Mukesh Kumar, Sabyasachi Mitra, Sonali Paul Mazumdar, Bijan Majumdar, Amit Ranjan Saha, Shiv Ram Singh, Biswajit Pramanick, Ahmed Gaber, Walaa F. Alsanie, Akbar Hossain. Improvement of Soil Health and System Productivity through Crop Diversification and Residue Incorporation under Jute-Based Different Cropping Systems. Agronomy. 2021; 11 (8):1622.

Chicago/Turabian Style

Mukesh Kumar; Sabyasachi Mitra; Sonali Paul Mazumdar; Bijan Majumdar; Amit Ranjan Saha; Shiv Ram Singh; Biswajit Pramanick; Ahmed Gaber; Walaa F. Alsanie; Akbar Hossain. 2021. "Improvement of Soil Health and System Productivity through Crop Diversification and Residue Incorporation under Jute-Based Different Cropping Systems." Agronomy 11, no. 8: 1622.

Journal article
Published: 13 August 2021 in Sustainability
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The present study aims to improve biomass and biochemical constituents, especially lipid production of Anabaena variabilis and Nostoc muscorum by formulating an optimal growth condition using various concentrations of nutrients (NO3, PO43− and CO32−) for biodiesel production. The supplementation of the three nutrients by +50% showed the maximum dry weight and biomass productivity, while the macromolecule contents were varied. The depletion of N-NO3 by 50% N-NO3 showed the maximum lipid yield (146.67 mg L−1) in A. variabilis and the maximum carbohydrate contents (285.33 mg L−1) in N. muscorum with an increase of 35% and 30% over control of the synthetic medium, respectively. However, variation in P-PO43− and C-CO32− showed insignificant improving results for all biochemical compositions in both cyanobacteria. A. variabilis was the superior species for lipid and protein accumulation; however, N. muscorum showed the maximum carbohydrate content. Accordingly, A. variabilis was selected for biodiesel production. In A. variabilis, −50% N-NO3 resulted in 35% higher lipid productivity compared to the control. Furthermore, the fatty acid profile and biodiesel quality-related parameters have improved under this condition. This study has revealed the strategies to improve A. variabilis lipid productivity for biodiesel production for small-scale in vitro application in terms of fuel quality under low nitrate levels.

ACS Style

Shimaa M. El Shafay; Ahmed Gaber; Walaa F. Alsanie; Mostafa E. Elshobary. Influence of Nutrient Manipulation on Growth and Biochemical Constituent in Anabaena variabilis and Nostoc muscorum to Enhance Biodiesel Production. Sustainability 2021, 13, 9081 .

AMA Style

Shimaa M. El Shafay, Ahmed Gaber, Walaa F. Alsanie, Mostafa E. Elshobary. Influence of Nutrient Manipulation on Growth and Biochemical Constituent in Anabaena variabilis and Nostoc muscorum to Enhance Biodiesel Production. Sustainability. 2021; 13 (16):9081.

Chicago/Turabian Style

Shimaa M. El Shafay; Ahmed Gaber; Walaa F. Alsanie; Mostafa E. Elshobary. 2021. "Influence of Nutrient Manipulation on Growth and Biochemical Constituent in Anabaena variabilis and Nostoc muscorum to Enhance Biodiesel Production." Sustainability 13, no. 16: 9081.

Journal article
Published: 11 August 2021 in Plants
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Very little is known about the changes that occur in soil organic carbon (SOC) and total nitrogen (TN) under an intensive rice-based cropping system following the change to minimal tillage and increased crop residue retention in the Gangetic Plains of South Asia. The field experiment was conducted for 3 years at Rajbari, Bangladesh to examine the impact of tillage practices and crop residue retention on carbon (C) and nitrogen (N) cycling. The experiment comprised four tillage practices—conventional tillage (CT), zero tillage (ZT), strip-tillage (ST), and bed planting (BP) in combination with two residue retention levels—increased residue (R50%) and low residue (R20%—the current practice). The TN, SOC, and mineral N (NH4+-N and NO3-N) were measured in the soil at different crop growth stages. After 3 years, ZT, ST, and BP sequestered 12, 11, and 6% more SOC, and 18, 13, and 10% more TN, respectively than the conventional crop establishment practice at 0–5 cm soil depth. The accumulation of SOC and TN was also higher compared to the initial SOC and TN in soil. Among the tillage practices, the maximum SOC and TN sequestration were recorded with ST and with R50% that might be attributed to reduced mineralization of C and N in soil particularly with increased residue retention, since decay rates of potentially mineralizable C was lower in the ST with both the residue retention practices. Increased residue retention and minimum tillage practices after nine consecutive crops has altered the C and N cycling by slowing the in-season turnover of C and N, reducing the level of nitrate-N available to plants in the growing season and increasing retained soil levels of SOC and TN.

ACS Style

Nazmus Salahin; Khairul Alam; Sharif Ahmed; Mohammad Jahiruddin; Ahmed Gaber; Walaa F. Alsanie; Akbar Hossain; Richard W. Bell. Carbon and Nitrogen Mineralization in Dark Grey Calcareous Floodplain Soil Is Influenced by Tillage Practices and Residue Retention. Plants 2021, 10, 1650 .

AMA Style

Nazmus Salahin, Khairul Alam, Sharif Ahmed, Mohammad Jahiruddin, Ahmed Gaber, Walaa F. Alsanie, Akbar Hossain, Richard W. Bell. Carbon and Nitrogen Mineralization in Dark Grey Calcareous Floodplain Soil Is Influenced by Tillage Practices and Residue Retention. Plants. 2021; 10 (8):1650.

Chicago/Turabian Style

Nazmus Salahin; Khairul Alam; Sharif Ahmed; Mohammad Jahiruddin; Ahmed Gaber; Walaa F. Alsanie; Akbar Hossain; Richard W. Bell. 2021. "Carbon and Nitrogen Mineralization in Dark Grey Calcareous Floodplain Soil Is Influenced by Tillage Practices and Residue Retention." Plants 10, no. 8: 1650.

Journal article
Published: 24 July 2021 in Healthcare
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The World Health Organization (WHO) announced COVID-19, a novel coronavirus outbreak, as a pandemic in 2020. In the month of February 2020, the disease began to spread through the Middle East. The first case of COVID-19 in the Kingdom of Saudi Arabia was identified in March 2020, and it is now one of the region’s most affected countries. Analyzing the disease’s propagation pattern may aid in the development of pandemic-fighting strategies. This study aims to analyze the trend of COVID-19’s spread, its recovery, and mortality in the Kingdom of Saudi Arabia (KSA). Two to three major cities from the 13 provinces of the country were chosen, and the rate of infection recovery was recorded from the first month until the number of confirmed cases showed a decline. The data published on the official Ministry of Health website were recorded on an Excel sheet, graphically represented as figures to indicate the pattern of spread. According to the study’s findings, COVID-19 positive cases were discovered in the majority of provinces as early as March 2020. The province of Makkah had the largest number of COVID-19 positive cases (30.7%), followed by Riyadh (23%). The province of Al Jowf had the lowest number of COVID-19 cases (0.3%). Tabuk province had the highest rate of recovery (97.8%), followed by the Northern Border Province (96.7%). Makkah province had the highest mortality rate (2.6%), followed by Al Jawf province (2.4%). The peak case–fatality ratio was recorded in August and September. The highest number of tests to detect the COVID-19 was performed in the month of July, and the highest percentage of positive cases was detected in June (19.55%). All the provinces from the month of September 2020 showed a progressive decline in the number of confirmed COVID-19 cases. According to this study, COVID-19 infection was found in the majority of Saudi Arabian provinces in March 2020, with a peak in June–July 2020. Considering the climatic and demographic characteristics of the region, specific modalities need to be adopted in collaboration with international guidelines to defeat the COVID-19 pandemic.

ACS Style

Mohammed Alharbi; Syed Rabbani; Syed Asdaq; Abdulhakeem Alamri; Walaa Alsanie; Majid Alhomrani; Yahya Mohzari; Ahmed Alrashed; Reem Bamogaddam; Saleh Alajlan; Mansour Alharbi; Norah Aldhawyan; Saeed Najmi. Infection Spread, Recovery, and Fatality from Coronavirus in Different Provinces of Saudi Arabia. Healthcare 2021, 9, 931 .

AMA Style

Mohammed Alharbi, Syed Rabbani, Syed Asdaq, Abdulhakeem Alamri, Walaa Alsanie, Majid Alhomrani, Yahya Mohzari, Ahmed Alrashed, Reem Bamogaddam, Saleh Alajlan, Mansour Alharbi, Norah Aldhawyan, Saeed Najmi. Infection Spread, Recovery, and Fatality from Coronavirus in Different Provinces of Saudi Arabia. Healthcare. 2021; 9 (8):931.

Chicago/Turabian Style

Mohammed Alharbi; Syed Rabbani; Syed Asdaq; Abdulhakeem Alamri; Walaa Alsanie; Majid Alhomrani; Yahya Mohzari; Ahmed Alrashed; Reem Bamogaddam; Saleh Alajlan; Mansour Alharbi; Norah Aldhawyan; Saeed Najmi. 2021. "Infection Spread, Recovery, and Fatality from Coronavirus in Different Provinces of Saudi Arabia." Healthcare 9, no. 8: 931.

Review
Published: 22 July 2021 in Pharmaceuticals
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Protein kinase inhibitors (PKIs) are important therapeutic agents. As of 31 May 2021, the United States Food and Drug Administration (USFDA) has approved 70 PKIs. Most of the PKIs are employed to treat cancer and inflammatory diseases. Imatinib was the first PKI approved by USFDA in 2001. This review summarizes the compound patents and the essential polymorph patents of the PKIs approved by the USFDA from 2001 to 31 May 2021. The dates on the generic drug availability of the PKIs in the USA market have also been forecasted. It is expected that 19 and 48 PKIs will be genericized by 2025 and 2030, respectively, due to their compound patent expiry. This may reduce the financial toxicity associated with the existing PKIs. There are nearly 535 reported PKs. However, the USFDA approved PKIs target only about 10–15% of the total said PKs. As a result, there are still a large number of unexplored PKs. As the field advances during the next 20 years, one can anticipate that PKIs with many scaffolds, chemotypes, and pharmacophores will be developed.

ACS Style

Mohd. Imran; Syed Mohammed Basheeruddin Asdaq; Shah Alam Khan; Dhanalekshmi Unnikrishnan Meenakshi; Abdulhakeem S. Alamri; Walaa F. Alsanie; Majid Alhomrani; Yahya Mohzari; Ahmed Alrashed; Mohammed AlMotairi; Eman H. Alkhaldi; Abeer K. Alorabi; Ahmed Subeh Alshrari; Mohammad Tauseef; Abida Abida; Saleh I. Alaqel; Ozair Alam; Afroz Bakht. Innovations and Patent Trends in the Development of USFDA Approved Protein Kinase Inhibitors in the Last Two Decades. Pharmaceuticals 2021, 14, 710 .

AMA Style

Mohd. Imran, Syed Mohammed Basheeruddin Asdaq, Shah Alam Khan, Dhanalekshmi Unnikrishnan Meenakshi, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani, Yahya Mohzari, Ahmed Alrashed, Mohammed AlMotairi, Eman H. Alkhaldi, Abeer K. Alorabi, Ahmed Subeh Alshrari, Mohammad Tauseef, Abida Abida, Saleh I. Alaqel, Ozair Alam, Afroz Bakht. Innovations and Patent Trends in the Development of USFDA Approved Protein Kinase Inhibitors in the Last Two Decades. Pharmaceuticals. 2021; 14 (8):710.

Chicago/Turabian Style

Mohd. Imran; Syed Mohammed Basheeruddin Asdaq; Shah Alam Khan; Dhanalekshmi Unnikrishnan Meenakshi; Abdulhakeem S. Alamri; Walaa F. Alsanie; Majid Alhomrani; Yahya Mohzari; Ahmed Alrashed; Mohammed AlMotairi; Eman H. Alkhaldi; Abeer K. Alorabi; Ahmed Subeh Alshrari; Mohammad Tauseef; Abida Abida; Saleh I. Alaqel; Ozair Alam; Afroz Bakht. 2021. "Innovations and Patent Trends in the Development of USFDA Approved Protein Kinase Inhibitors in the Last Two Decades." Pharmaceuticals 14, no. 8: 710.

Journal article
Published: 24 June 2021 in Sustainability
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The formulator of aquatic diets is part of a continuous search for alternative protein sources instead of depreciated fish meal. The utilization of zooplankton as a feed ingredient is an interesting trend due to their high-quality protein content and abundance of essential nutrients. The current study aims to investigate the effects of partial and total replacement of fish meal (FM) by Dahpnia magna meal (DMM) on growth performance, feed utilization, histological, and economic status of mullet, M. cephalus, larvae. In addition to the control diet, 100% FM, D0, four diets containing DMM at different levels were used: 25% (D25), 50% (D50), 75% (D75), and 100% (D100) replacement of fish meal. A total of 300 larvae (0.097 ± 0.001 g) were equally divided into five groups (three replicate per each group) at a density of 200 larvae m−3. The aquariums were renewed at a rate of 30% daily. During the 60-day experimental period, all larvae were fed their respective diets at a level of 20% of live body weight, five times a day (9.00 a.m., 12.00, 15.00, 18.00, and 21.00 p.m.). The results indicated that compared to D0, fish fed D75 recorded the highest significant value of growth, and feed utilization parameters, while fish fed D100 achieved the lowest feed cost and incidence cost, and the highest profit index and economic efficiency ratio. A strong correlation was reported among weight gain, feed conversion ratio and fish meal replacement with DMM; R2 = 0.94 and 0.91, respectively. The fit regression model representing mullet response to FM replacement with DMM is a poly-nominal regression model with maximum response at 75–100%. The histological investigation of the intestine revealed an improvement of histomorphometric indices and goblet cell number with increasing DMM inclusion levels. These findings confirmed that 75% to 100% partial substitution of FM with DMM is the ideal replacement for mullet, M. cephalus, larvae for improving fish growth performance and feed utilization.

ACS Style

Hamdy Abo-Taleb; Mohamed Ashour; Mohamed Elokaby; Mohamed Mabrouk; Mohamed El-Feky; Othman Abdelzaher; Ahmed Gaber; Walaa Alsanie; Abdallah Mansour. Effect of a New Feed Daphnia magna (Straus, 1820), as a Fish Meal Substitute on Growth, Feed Utilization, Histological Status, and Economic Revenue of Grey Mullet, Mugil cephalus (Linnaeus 1758). Sustainability 2021, 13, 7093 .

AMA Style

Hamdy Abo-Taleb, Mohamed Ashour, Mohamed Elokaby, Mohamed Mabrouk, Mohamed El-Feky, Othman Abdelzaher, Ahmed Gaber, Walaa Alsanie, Abdallah Mansour. Effect of a New Feed Daphnia magna (Straus, 1820), as a Fish Meal Substitute on Growth, Feed Utilization, Histological Status, and Economic Revenue of Grey Mullet, Mugil cephalus (Linnaeus 1758). Sustainability. 2021; 13 (13):7093.

Chicago/Turabian Style

Hamdy Abo-Taleb; Mohamed Ashour; Mohamed Elokaby; Mohamed Mabrouk; Mohamed El-Feky; Othman Abdelzaher; Ahmed Gaber; Walaa Alsanie; Abdallah Mansour. 2021. "Effect of a New Feed Daphnia magna (Straus, 1820), as a Fish Meal Substitute on Growth, Feed Utilization, Histological Status, and Economic Revenue of Grey Mullet, Mugil cephalus (Linnaeus 1758)." Sustainability 13, no. 13: 7093.

Journal article
Published: 19 June 2021 in Saudi Journal of Biological Sciences
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In late December 2019, an outbreak of severe acute respiratory syndrome coronavirus 2 (SARS COV-2) occurred in the city of Wuhan, the capital of the Hubei province in the central part of the People’s Republic of China (Ren et al., 2020). In Saudi Arabia, the first case of COVID-19 was reported in March 2, 2020. In March 8, 2020, the Saudi authorities adopted the lockdown strategy to contain the disease. The aim of this study was to determine the effectiveness of the various phases of the lockdown strategy in Saudi Arabia and its impact on the basic reproductive number (R0) of the COVID-19 outbreak. The timeline of the COVID-19 outbreak in Saudi Arabia was divided into three-time intervals. Google Mobility Community Reports (2020) was used to estimate the changes in community mobility during the various phases of the lockdown. The basic reproductive number (R0) of the COVID-19 outbreak was calculated daily using the Susceptible, Infected and Recovered (SIR) model based on the Saudi Ministry of Health (MOH) daily reports. This is a standard system to determine the spread of the virus on the basis of infection rate, quarantine rate as well as confirmation rate. The mean values of the calculated R0 during each interval were compared using one-way ANOVA test. There was no statistically significant difference between the mean values of the different phases of the lockdown (P < 0.05). Moreover, mean R0 value of the second interval was 0.09 higher than the initial interval with free community mobility. Furthermore, the mean R0 values of the third interval with the full lockdown was 0.28 higher than the initial interval. Early implementation of lockdown strategy combined with other social distancing strategies help in containing infectious outbreaks in their early phases. Continuous assessment of such strategies’ effectiveness provides decision makers with precious information needed to justify their application when considering their economic impact.

ACS Style

Saleh Ahmad Alajlan; Noara K. Alhusseini; Syed Mohammed Basheeruddin Asdaq; Yahya Mohzari; Ahmad Alamer; Ahmed A. Alrashed; Abdulhakeem S. Alamri; Walaa F. Alsanie; Majid Alhomrani. The impact of lockdown strategies on the basic reproductive number of coronavirus (COVID-19) cases in Saudi Arabia. Saudi Journal of Biological Sciences 2021, 28, 4926 -4930.

AMA Style

Saleh Ahmad Alajlan, Noara K. Alhusseini, Syed Mohammed Basheeruddin Asdaq, Yahya Mohzari, Ahmad Alamer, Ahmed A. Alrashed, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani. The impact of lockdown strategies on the basic reproductive number of coronavirus (COVID-19) cases in Saudi Arabia. Saudi Journal of Biological Sciences. 2021; 28 (9):4926-4930.

Chicago/Turabian Style

Saleh Ahmad Alajlan; Noara K. Alhusseini; Syed Mohammed Basheeruddin Asdaq; Yahya Mohzari; Ahmad Alamer; Ahmed A. Alrashed; Abdulhakeem S. Alamri; Walaa F. Alsanie; Majid Alhomrani. 2021. "The impact of lockdown strategies on the basic reproductive number of coronavirus (COVID-19) cases in Saudi Arabia." Saudi Journal of Biological Sciences 28, no. 9: 4926-4930.

Journal article
Published: 15 June 2021 in Foods
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World Health Organization classified Listeria monocytogenes as a major notable foodborne pathogen associated with high mortality and hospitalization. The study reports the prevalence, antibiogram, virulence determination and genetic characterization of L. monocytogenes from different food products. A total of 250 food samples, fifty samples each from raw milk, ice cream, minced meat, fish fillet and sausage were collected from the Menoufiya governorate in Egypt. L. monocytogenes was detected in 17 (6.8%) of the tested food samples including minced meat (14%), fish fillet (8%), sausage (6%) and raw milk (6%). The antimicrobial susceptibility assay of 17 L. monocytogenes isolates against seventeen antibiotics belonging to eight antibiotics classes revealed a high susceptibility to norfloxacin (82.3%), amoxicillin-clavulanic acid (76.4%), cefotaxime (70.5%), erythromycin (64.6%), amoxicillin (64.6%), gentamicin (58.7%) and vancomycin (58.7%). While, high resistance was observed against oxytetracycline (76.4%), trimethoprim-sulfamethoxazole (76.4%), chloramphenicol (70.5%), doxycycline (64.6%), levofloxacin (41.2%) and azithromycin (41.2%). Of note, all L. monocytogenes isolates were multidrug-resistant. The multiplex PCR successfully amplified L. monocytogenes in all tested isolates. Screening of the five virulence-related genes revealed the hlyA and iap as the most prevalent genes followed by actA gene, however, the inlA and prfA genes were not detected in any of the studied isolates. The partial 16S rRNA gene sequencing of three L. monocytogenes isolates showed a high nucleotide similarity (99.1–99.8%) between the study isolates and various global clones, and phylogenetic analysis clustered these L. monocytogenes strains with other Listeria species including L. welshimeri, L. seeligeri and L. innocua. This study demonstrates the impact of L. monocytogenes as a major contaminant of various food products and suggests more attention to the awareness and hygienic measures in the food industry.

ACS Style

Eman Abdeen; Walid Mousa; Ola. Harb; Gehad Fath-Elbab; Mohammed Nooruzzaman; Ahmed Gaber; Walaa Alsanie; Ahmed Abdeen. Prevalence, Antibiogram and Genetic Characterization of Listeria monocytogenes from Food Products in Egypt. Foods 2021, 10, 1381 .

AMA Style

Eman Abdeen, Walid Mousa, Ola. Harb, Gehad Fath-Elbab, Mohammed Nooruzzaman, Ahmed Gaber, Walaa Alsanie, Ahmed Abdeen. Prevalence, Antibiogram and Genetic Characterization of Listeria monocytogenes from Food Products in Egypt. Foods. 2021; 10 (6):1381.

Chicago/Turabian Style

Eman Abdeen; Walid Mousa; Ola. Harb; Gehad Fath-Elbab; Mohammed Nooruzzaman; Ahmed Gaber; Walaa Alsanie; Ahmed Abdeen. 2021. "Prevalence, Antibiogram and Genetic Characterization of Listeria monocytogenes from Food Products in Egypt." Foods 10, no. 6: 1381.

Journal article
Published: 15 June 2021 in Diversity
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Burullus Lake is Egypt’s second most important coastal lagoon. The present study aimed to shed light on the different types of polluted waters entering the lake from various drains, as well as to evaluate the zooplankton community, determine the physical and chemical characteristics of the waters, and study the eutrophication state based on three years of seasonal monitoring from 2017 to 2019 at 12 stations. The results revealed that Rotifera, Copepoda, Protozoa, and Cladocera dominated the zooplankton population across the three-year study period, with a total of 98 taxa from 59 genera and 10 groups detected in the whole-body lake in 2018 and 2019, compared to 93 species from 52 genera in 2017. Twelve representative surface water samples were collected from the lake to determine physicochemical parameters, i.e., temperature, pH, salinity, dissolved oxygen, biological oxygen demand, chemical oxygen demand, ammonia-N, nitrate–N, nitrate-N, total nitrogen, total phosphorus, dissolved reactive phosphorus, and chlorophyll-a, as well as Fe, Cu, Zn, Cr, Ni, Cd, and Pb ions. Based on the calculations of the water quality index (WQI), the lake was classified as having good water quality. However, the trophic state is ranked as hyper-eutrophic and high trophic conditions.

ACS Style

Ahmed Alprol; Ahmed Heneash; Asgad Soliman; Mohamed Ashour; Walaa Alsanie; Ahmed Gaber; Abdallah Mansour. Assessment of Water Quality, Eutrophication, and Zooplankton Community in Lake Burullus, Egypt. Diversity 2021, 13, 268 .

AMA Style

Ahmed Alprol, Ahmed Heneash, Asgad Soliman, Mohamed Ashour, Walaa Alsanie, Ahmed Gaber, Abdallah Mansour. Assessment of Water Quality, Eutrophication, and Zooplankton Community in Lake Burullus, Egypt. Diversity. 2021; 13 (6):268.

Chicago/Turabian Style

Ahmed Alprol; Ahmed Heneash; Asgad Soliman; Mohamed Ashour; Walaa Alsanie; Ahmed Gaber; Abdallah Mansour. 2021. "Assessment of Water Quality, Eutrophication, and Zooplankton Community in Lake Burullus, Egypt." Diversity 13, no. 6: 268.

Journal article
Published: 30 May 2021 in Saudi Journal of Biological Sciences
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Cigarette smoke is associated with several diseased states including defects in reproductive behavior. Salvadora persica (S. persica) known as the toothbrush plant is reported to possess several pharmacological properties including antidepressants and anxiolytics. The present research was done to determine the libido-protective effect of S. persica in chronic cigarette smoke-exposed rats. The decoction of freshly dried roots of S. persica (50, 100, and 200 mg/kg, oral) was administered to the chronic-cigarette smoke-exposed adult rats. The parameters related to libido were recorded using a close-camera circuit (CCTV). Serum corticosterone and testosterone levels were estimated. Further, the phytochemical constituents were identified in the decoction. The data obtained were analyzed using one-way analysis of variance and significance was considered at p<0.05. The observation from the study revealed that cigarette smoke exposure reduces the sexual activity parameters significantly (p<0.01), besides elevated the serum corticosterone and suppressed the testosterone levels in rats. Administration of S. persica at 200 mg/kg improved significantly (p<0.05) the parameters related to libido. The decoction also reversed the changes in the levels of tested hormones in serum. Interpretation and Conclusion: The findings indicate that a 200 mg/kg S. persica decoction can protect libido in chronic cigarette smoke-exposed rats. The activity may be due to the presence of several phytoconstituents such as alkaloid, flavonoids and phytosterols that might produce vasodilatory effect in sex organs and enhance the synthesis of endogenous testosterone to improve libido characteristics weakened by chronic cigarette smoke exposure.

ACS Style

Syed Imam Rabbani; Sultan Sajid; Vasudevan Mani; Salman Mohammed Afroz; Omar Khan; Syed Mohammed Basheeruddin Asdaq; Farhana Yasmin; Abdulhakeem S. Alamri; Walaa F. Alsanie; Majid Alhomrani; Yahya Mohzari; Ahmed Alrashed; Hamdan Najib Alajami; Awad Othman Aljohani; Rakan Fahad Alamer; Abdulmajead Khalid Alanazi. Salvadora persica protects libido by reducing corticosterone and elevating the testosterone levels in chronic cigarette smoke exposure rats. Saudi Journal of Biological Sciences 2021, 28, 4931 -4937.

AMA Style

Syed Imam Rabbani, Sultan Sajid, Vasudevan Mani, Salman Mohammed Afroz, Omar Khan, Syed Mohammed Basheeruddin Asdaq, Farhana Yasmin, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani, Yahya Mohzari, Ahmed Alrashed, Hamdan Najib Alajami, Awad Othman Aljohani, Rakan Fahad Alamer, Abdulmajead Khalid Alanazi. Salvadora persica protects libido by reducing corticosterone and elevating the testosterone levels in chronic cigarette smoke exposure rats. Saudi Journal of Biological Sciences. 2021; 28 (9):4931-4937.

Chicago/Turabian Style

Syed Imam Rabbani; Sultan Sajid; Vasudevan Mani; Salman Mohammed Afroz; Omar Khan; Syed Mohammed Basheeruddin Asdaq; Farhana Yasmin; Abdulhakeem S. Alamri; Walaa F. Alsanie; Majid Alhomrani; Yahya Mohzari; Ahmed Alrashed; Hamdan Najib Alajami; Awad Othman Aljohani; Rakan Fahad Alamer; Abdulmajead Khalid Alanazi. 2021. "Salvadora persica protects libido by reducing corticosterone and elevating the testosterone levels in chronic cigarette smoke exposure rats." Saudi Journal of Biological Sciences 28, no. 9: 4931-4937.

Journal article
Published: 27 May 2021 in Molecules
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This study was conducted to determine the potential interaction of aged garlic extract (AGE) with carvedilol (CAR), as well as to investigate the role of S-allyl-l-cysteine (SAC), an active constituent of AGE, in rats with isoproterenol (ISO)-induced myocardial dysfunction. At the end of three weeks of treatment with AGE (2 and 5 mL/kg) or SAC (13.1 and 32.76 mg/kg), either alone or along with CAR (10 mg/kg) in the respective groups of animals, ISO was administered subcutaneously to induce myocardial damage. Myocardial infarction (MI) diagnostic predictor enzymes, lactate dehydrogenase (LDH) and creatinine kinase (CK-MB), were measured in both serum and heart tissue homogenates (HTH). Superoxide dismutase (SOD), catalase, and thiobarbituric acid reactive species (TBARS) were estimated in HTH. When compared with other groups, the combined therapy of high doses of AGE and SAC given alone or together with CAR caused a significant decrease in serum LDH and CK-MB activities. Further, significant rise in the LDH and CK-MB activities in HTH was noticed in the combined groups of AGE and SAC with CAR. It was also observed that both doses of AGE and SAC significantly increased endogenous antioxidants in HTH. Furthermore, histopathological observations corroborated the biochemical findings. The cytoprotective potential of SAC and AGE were dose-dependent, and SAC was more potent than AGE. The protection offered by aged garlic may be attributed to SAC. Overall, the results indicated that a high dose of AGE and its constituent SAC, when combined with carvedilol, has a synergistic effect in preventing morphological and physiological changes in the myocardium during ISO-induced myocardial damage.

ACS Style

Syed Asdaq; Obulesu Challa; Abdulhakeem Alamri; Walaa Alsanie; Majid Alhomrani; Abdulrahman Almutiri; Majed Alshammari. Cytoprotective Potential of Aged Garlic Extract (AGE) and Its Active Constituent, S-allyl-l-cysteine, in Presence of Carvedilol during Isoproterenol-Induced Myocardial Disturbance and Metabolic Derangements in Rats. Molecules 2021, 26, 3203 .

AMA Style

Syed Asdaq, Obulesu Challa, Abdulhakeem Alamri, Walaa Alsanie, Majid Alhomrani, Abdulrahman Almutiri, Majed Alshammari. Cytoprotective Potential of Aged Garlic Extract (AGE) and Its Active Constituent, S-allyl-l-cysteine, in Presence of Carvedilol during Isoproterenol-Induced Myocardial Disturbance and Metabolic Derangements in Rats. Molecules. 2021; 26 (11):3203.

Chicago/Turabian Style

Syed Asdaq; Obulesu Challa; Abdulhakeem Alamri; Walaa Alsanie; Majid Alhomrani; Abdulrahman Almutiri; Majed Alshammari. 2021. "Cytoprotective Potential of Aged Garlic Extract (AGE) and Its Active Constituent, S-allyl-l-cysteine, in Presence of Carvedilol during Isoproterenol-Induced Myocardial Disturbance and Metabolic Derangements in Rats." Molecules 26, no. 11: 3203.

Journal article
Published: 21 May 2021 in Plants
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Bioactive molecules derived from seaweed extracts are revolutionary bio-stimulants used to enhance plant growth and increase yield production. This study evaluated the effectiveness of a commercially available seaweed liquid extract, namely, True-Algae-Max (TAM®), as a plant growth stimulant on nutritional, and antioxidant activity of Capsicum annuum. Three concentrations of TAM® (0.25, 0.5, and 1%) of various NPK: TAM® ratios were investigated via foliar spray, over 2017 and 2018 cultivation seasons, under greenhouse conditions. TAM® is rich in phytochemical compounds, such as ascorbic acid (1.66 mg g−1), phenolics (101.67 mg g−1), and flavonoids (2.60 mg g−1) that showed good antioxidant activity (54.52 mg g−1) and DPPH inhibition of 70.33%. Promoting measured parameter results stated the extensive potentiality of TAM® application, in comparison with conventional NPK treatment. Yield and composition of C. annuum were significantly improved in all TAM® treated groups, especially the TAM0.5% concentration, which resulted in maximum yield (4.23 Kg m−2) and significant amounts of profuse biological molecules like chlorophyll, ascorbic, phenolic compounds, flavonoids, and total nutrients. Compared to the NPK control treatments, C. annuum treated with TAM0.5% improved the total antioxidant activity of hot Pepper from 162.16 to 190.95 mg g−1. These findings indicate that the extract of seaweed can be used as an environmentally friendly, multi-functional biostimulant in the agricultural field for more sustainable production, in addition to reducing the use of hazardous synthetic fertilizers.

ACS Style

Mohamed Ashour; Shimaa Hassan; Mostafa Elshobary; Gamal Ammar; Ahmed Gaber; Walaa Alsanie; Abdallah Mansour; Rania El-Shenody. Impact of Commercial Seaweed Liquid Extract (TAM®) Biostimulant and Its Bioactive Molecules on Growth and Antioxidant Activities of Hot Pepper (Capsicum annuum). Plants 2021, 10, 1045 .

AMA Style

Mohamed Ashour, Shimaa Hassan, Mostafa Elshobary, Gamal Ammar, Ahmed Gaber, Walaa Alsanie, Abdallah Mansour, Rania El-Shenody. Impact of Commercial Seaweed Liquid Extract (TAM®) Biostimulant and Its Bioactive Molecules on Growth and Antioxidant Activities of Hot Pepper (Capsicum annuum). Plants. 2021; 10 (6):1045.

Chicago/Turabian Style

Mohamed Ashour; Shimaa Hassan; Mostafa Elshobary; Gamal Ammar; Ahmed Gaber; Walaa Alsanie; Abdallah Mansour; Rania El-Shenody. 2021. "Impact of Commercial Seaweed Liquid Extract (TAM®) Biostimulant and Its Bioactive Molecules on Growth and Antioxidant Activities of Hot Pepper (Capsicum annuum)." Plants 10, no. 6: 1045.

Journal article
Published: 20 May 2021 in Crystals
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This research aimed to produce new 1-[(aryl)(3-amino-5-oxopyrazolidin-4-ylidene) methyl]-2-oxo-1,2-dihydroquinoline-3-carboxylic acid derivatives and check their anticancer effect against the breast cancer MCF-7 cell line. The 2-oxo-1,2-dihydroquinoline-3-carboxylic acid (4) compound was obtained by hydrolyzing ethyl 2-oxo-1,2-dihydroquinoline-3-carboxylate (2) with thiourea and anhydrous potassium carbonate ethanol, which was then treated with ethyl 3-substituted 2-cyanoacrylates (6) in the presence of triethylamine in diethyl formamide to give 1-[2-(ethoxy)carbonyl-2-cyano-1-arylvinyl]-2-oxo-1,2-dihydroquinoline-3-carboxylic (7a,d). Cyclization of compound 7 with hydrazine hydrate ethanol inferred the association of 1-[(aryl)(3 amino-5-oxopyrazolidin-4-ylidene)methyl-2-oxo-1,2-dihydroquinol-3-carboxylates (8a,d). Spectroscopic and micro-analytical techniques such as IR, NMR, and elemental analysis were used to validate the structure of the synthesized organic compounds. The anticancer effects of the synthesized compounds 7a–d and 8a–d were tested by using the MTT assay on the MCF-7 cell line. When compared to the reference compound Dox, the compounds 7b,c and 8a–c demonstrated strong anticancer activity against the MCF-7 cell line. The anticancer effects of the synthesized compounds 7a–d and 8a–d were tested against the MCF-7 cell line, using MTT assay. The compounds 7b,c and 8a–c showed significant anticancer activity compared to the reference compound Dox against the MCF-7 cell line.

ACS Style

Ahmed Gaber; Walaa Alsanie; Majid Alhomrani; Abdulhakeem Alamri; Ibrahim El-Deen; Moamen Refat. Synthesis of 1-[(Aryl)(3-amino-5-oxopyrazolidin-4-ylidene) methyl]-2-oxo-1,2-dihydroquinoline-3-carboxylic Acid Derivatives and Their Breast Anticancer Activity. Crystals 2021, 11, 571 .

AMA Style

Ahmed Gaber, Walaa Alsanie, Majid Alhomrani, Abdulhakeem Alamri, Ibrahim El-Deen, Moamen Refat. Synthesis of 1-[(Aryl)(3-amino-5-oxopyrazolidin-4-ylidene) methyl]-2-oxo-1,2-dihydroquinoline-3-carboxylic Acid Derivatives and Their Breast Anticancer Activity. Crystals. 2021; 11 (5):571.

Chicago/Turabian Style

Ahmed Gaber; Walaa Alsanie; Majid Alhomrani; Abdulhakeem Alamri; Ibrahim El-Deen; Moamen Refat. 2021. "Synthesis of 1-[(Aryl)(3-amino-5-oxopyrazolidin-4-ylidene) methyl]-2-oxo-1,2-dihydroquinoline-3-carboxylic Acid Derivatives and Their Breast Anticancer Activity." Crystals 11, no. 5: 571.

Journal article
Published: 19 May 2021 in Crystals
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This study aimed to synthesize quinolinone derivatives and investigate their cytotoxic activity. The compound 1-azacoumarin-3-carboxylic acid (2-oxo-1H-quinoline-3-carboxylic acid) was obtained via the cyclocondensation of 2-hydroxybenzaldehyde with diethyl malonate in base catalyst to give ethyl coumarin-3-carboxylate, followed by the ammonolysis of ester (ethyl coumarin-3-carboxylate) with ammonia in the presence of anhydrous potassium carbonate. Treatment of 2-oxo-1H-quinoline-3-carboxylic acid with acetic anhydride, cinnamaldehyde, cinnamic acid and methyl 5-phenyl-2-cyano-2,4-pentadienoate under different conditions led to the formation of 1 (substituted) aza coumarin-3-carboxylic acids (1-N-(acetyl)-azacoumarin-3-carboxylic acid, 1-N-(2-Formyl-1-phenyl) vinyl-azacoumarin-3-carboxylic acids, 1-N-[2-(Hydroxy) carbonyl-1-(Phenyl) vinyl]-azacoumarin-3-carboxylic acid and 1-N-(4-Cyano-5-methoxy-5-oxo-1-Phenylpenta-1,3-diene-1-y)-azacoumarin-3-carboxylic 284 acid), respectively. The structures of synthesized 1-(substituted) azacoumarin-3-carboxylic acids were confirmed based on spectroscopic methods (IR and NMR), along with elemental analyses. Interestingly compound 6 demonstrated probable impacts as an anti-cancer drug against the MCF-7 cell line. The mechanism of action was assessed using a flow cytometric assay. The outcomes revealed that compound 6 could arrest the cell cycle at G2/M phase and pre-G1 apoptosis.

ACS Style

Ahmed Gaber; Walaa Alsanie; Majid Alhomrani; Abdulhakeem Alamri; Ibrahim El-Deen; Moamen Refat. Synthesis and Characterization of Some New Coumarin Derivatives as Probable Breast Anticancer MCF-7 Drugs. Crystals 2021, 11, 565 .

AMA Style

Ahmed Gaber, Walaa Alsanie, Majid Alhomrani, Abdulhakeem Alamri, Ibrahim El-Deen, Moamen Refat. Synthesis and Characterization of Some New Coumarin Derivatives as Probable Breast Anticancer MCF-7 Drugs. Crystals. 2021; 11 (5):565.

Chicago/Turabian Style

Ahmed Gaber; Walaa Alsanie; Majid Alhomrani; Abdulhakeem Alamri; Ibrahim El-Deen; Moamen Refat. 2021. "Synthesis and Characterization of Some New Coumarin Derivatives as Probable Breast Anticancer MCF-7 Drugs." Crystals 11, no. 5: 565.

Journal article
Published: 08 May 2021 in Saudi Pharmaceutical Journal
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One of the broadly talked about class of medications for their extravagantly expanded abuse is proton pump inhibitors (PPIs). In spite of the fact that, they are known to be profoundly useful, it is accounted for several adverse manifestations. Health care professionals can assume an essential part in controlling its irrational use. The purpose of this study was to explore the knowledge, attitude and behavior of health care professionals of Riyadh region of Saudi Arabia on the use of PPIs by a cross-sectional study design. The study data was obtained through a validated self-administered questionnaire covering knowledge (20 items), attitude (8 items) and behavior (6 items). Furthermore, demographic questions were placed to decide their effect on the intended three domains. The results were analysed by descriptive analysis and affirmed by multinomial regression method using SPSS-IBM 25. Of 414 surveyors, 121 (31%), 182 (44%) and 103 (25%) were doctors, pharmacist and nurses, respectively. Average age of participants' was 33.96 ± 8.37 years. Both doctors and pharmacist showed better degree of information (13.17/20 and 13.25/20) and good attitude (6.66/8 and 6.9/8) towards PPI use compared to nurses. Altogether higher extent of knowledge score showed by highly educated individuals, middle age groups and those with more practicing experience. The reliance on the utilization of PPI is less among pharmacist and nurses when compared to doctors. The outcome of the regression analysis exhibited that the odds of having low knowledge is more in young and bachelor degree holders. Healthcare professionals in the Riyadh area are generally positive about the use of PPIs. However, increasing their level of knowledge and reducing their reliance on PPIs must be strengthened. Frequent professional development programs and trainings for healthcare professionals are needed to minimize widespread PPI overuse.

ACS Style

Syed Mohammed Basheeruddin Asdaq; Marah Albasha; Asmaa Almutairi; Reham Alyabisi; Alaa Almuhaisni; Roaa Faqihi; Abdulhakeem S. Alamri; Walaa F. Alsanie; Majid Alhomrani. Use of proton pump inhibitors: An exploration of awareness, attitude and behavior of health care professionals of Riyadh, Saudi Arabia. Saudi Pharmaceutical Journal 2021, 29, 713 -718.

AMA Style

Syed Mohammed Basheeruddin Asdaq, Marah Albasha, Asmaa Almutairi, Reham Alyabisi, Alaa Almuhaisni, Roaa Faqihi, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani. Use of proton pump inhibitors: An exploration of awareness, attitude and behavior of health care professionals of Riyadh, Saudi Arabia. Saudi Pharmaceutical Journal. 2021; 29 (7):713-718.

Chicago/Turabian Style

Syed Mohammed Basheeruddin Asdaq; Marah Albasha; Asmaa Almutairi; Reham Alyabisi; Alaa Almuhaisni; Roaa Faqihi; Abdulhakeem S. Alamri; Walaa F. Alsanie; Majid Alhomrani. 2021. "Use of proton pump inhibitors: An exploration of awareness, attitude and behavior of health care professionals of Riyadh, Saudi Arabia." Saudi Pharmaceutical Journal 29, no. 7: 713-718.

Journal article
Published: 26 April 2021 in Animals
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The modern broiler industry faces huge challenges to keep high production quality and quantity, especially under environmental heat stress conditions. The negative effect of heat stress on broiler productivity is mediated by oxidative stress induction. The blue-green alga (Spirulina platensis) has many applications in poultry nutrition with the high levels of bioactive antioxidant compounds, which can alleviate the oxidative stress damage induced by high ambient temperature. The current study was designed to investigate the effects of dietary Spirulina inclusion at different levels on growth performance, redox status, carcass traits, meat quality, blood hematology, and metabolites profile of broilers subjected to cyclic heat stress. A total of 300 one-day-old Cobb-500 broiler chicks were recruited. Starting from day 21 to 42 of age, birds were randomly divided into five treatment groups with 6 replicates × 10 birds per group, where the first one was provided with the basal diet and reared under normal thermal conditions (23 ± 1 °C) to serve as a negative control. Meanwhile, the other four groups were exposed to cyclic heat stress (34 ± 1 °C for 8 h per day) and were fed a basal diet supplemented with Spirulina at a concentration of 0, 0.5, 1 or 1.5%. Spirulina supplementation to heat-stressed broilers was able to alleviate the negative impacts of heat stress on the final average daily gain, body weight and feed conversion ratio, with the best impact observed among the chickens fed 1% Spirulina. Hematological results indicate increasing hemoglobin and hematocrit levels with Spirulina supplementation compared to the non-supplemented stressed group. Further, Spirulina supplementation significantly influenced blood lipid metabolites marked by reduced serum cholesterol and low-density lipoprotein (LDL), and increased high-density lipoprotein (HDL) levels. The lipid peroxidation level was reduced (p < 0.05), while the antioxidant enzyme activity was increased with Spirulina supplementation to the heat-stressed group. Spirulina supplementation at 0.5 or 1% improved carcass dressing, breast and leg percentages. It can be concluded that dietary Spirulina supplementation at 0.5 or 1% to broiler reared under heat stress conditions can effectively improve broiler production performance and balance the redox status.

ACS Style

Eman Moustafa; Walaa Alsanie; Ahmed Gaber; Nancy Kamel; Abdulaziz Alaqil; Ahmed Abbas. Blue-Green Algae (Spirulina platensis) Alleviates the Negative Impact of Heat Stress on Broiler Production Performance and Redox Status. Animals 2021, 11, 1243 .

AMA Style

Eman Moustafa, Walaa Alsanie, Ahmed Gaber, Nancy Kamel, Abdulaziz Alaqil, Ahmed Abbas. Blue-Green Algae (Spirulina platensis) Alleviates the Negative Impact of Heat Stress on Broiler Production Performance and Redox Status. Animals. 2021; 11 (5):1243.

Chicago/Turabian Style

Eman Moustafa; Walaa Alsanie; Ahmed Gaber; Nancy Kamel; Abdulaziz Alaqil; Ahmed Abbas. 2021. "Blue-Green Algae (Spirulina platensis) Alleviates the Negative Impact of Heat Stress on Broiler Production Performance and Redox Status." Animals 11, no. 5: 1243.

Journal article
Published: 17 April 2021 in Sustainability
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This study aimed to understand the effect of commercial seaweed extract as a biofertilizer, named True-Algae-Max (TAM®), on the yield, nutritional, antioxidant, and cytotoxic activity of Eruca vesicaria. Three concentrations of TAM® (5, 10, and 15%) were studied by foliar spray over the two cultivation years (2016 and 2017) without any chemical fertilizer, along with a control consisting of synthetic nitrogen, phosphorus and potassium (NPK) fertilizers. The yield and composition of E. vesicaria were significantly improved in all treatments, particularly at 10% concentration of TAM®, which resulted in maximum yield (1.99 kg m−2) and significant amounts of chlorophyll, carotenoids, phenolic compounds, flavonoids and total nutrients. Compared to the NPK control, E. vesicaria grown with 10% of TAM® improved total antioxidant activity from 41.80 to 49.36 mg g−1 and cytotoxicity from 25.30 to 60.40% with an IC50 value 85.7 µg mL−1 against the hepatocellular carcinoma cell line (HepG2). These findings indicate that seaweed extract can generally be used as a safe potential multifunctional biofertilizer in the agricultural field. The use of seaweed as a biofertilizer could potentially help mitigate the adverse effects of main nutrient deficiencies, diminishing the use of chemical fertilizers.

ACS Style

Shimaa Hassan; Mohamed Ashour; Ahmed Soliman; Hesham Hassanien; Walaa Alsanie; Ahmed Gaber; Mostafa Elshobary. The Potential of a New Commercial Seaweed Extract in Stimulating Morpho-Agronomic and Bioactive Properties of Eruca vesicaria (L.) Cav. Sustainability 2021, 13, 4485 .

AMA Style

Shimaa Hassan, Mohamed Ashour, Ahmed Soliman, Hesham Hassanien, Walaa Alsanie, Ahmed Gaber, Mostafa Elshobary. The Potential of a New Commercial Seaweed Extract in Stimulating Morpho-Agronomic and Bioactive Properties of Eruca vesicaria (L.) Cav. Sustainability. 2021; 13 (8):4485.

Chicago/Turabian Style

Shimaa Hassan; Mohamed Ashour; Ahmed Soliman; Hesham Hassanien; Walaa Alsanie; Ahmed Gaber; Mostafa Elshobary. 2021. "The Potential of a New Commercial Seaweed Extract in Stimulating Morpho-Agronomic and Bioactive Properties of Eruca vesicaria (L.) Cav." Sustainability 13, no. 8: 4485.

Research article
Published: 16 April 2021 in Bioinorganic Chemistry and Applications
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The solid adducts of SnCl2.(3amt).H2O, SnCl2.2(3amt).H2O, CdCl2.(3amt), CdCl2.2(3amt), SnCl2.(2mct).0.5H2O, SnCl2.2(2mct), CdCl2.(2mct), CdCl2.2(2mct).H2O, SnCl2.(2mcp).1.5H2O, >2.2(2mcp).4H2O, CdCl2.(2mcp), CdCl2.2(2mcp), SnCl2.(4amt).4H2O, SnCl2.2(4amt).1.5H2O, CdCl2.(4amt).H2O, and CdCl2.2(4amt) (where the 3amt, 4amt, 2mct, and 2mcp represent 3-amino-1,2,4-triazole, 4-amino-1,2,4-triazole, 2-mercaptothiazoline, and 2-mercaptopyridine simple organic chelates, respectively) were prepared using a solid-state route and investigated by CHN elemental analysis and infrared spectroscopy. Additionally, we investigated the thermogravimetric characterization and antimicrobial proprieties. It is verified that for 3amt and 4amt adducts, the coordination occurs through nitrogen atom. For 2mct compounds, the coordination occurs through nitrogen (Sn) or sulfur (Cd). For 2mcp adducts, both coordination sites nitrogen and sulfur are involved. By examination of TG curves, it is confirmed that for each hydrated compounds, the first mass loss step is linked with the release of water molecules followed by the release of ligand molecules and sublimation of the metal chloride. Furthermore, it is verified that, considering only the release of ligand molecules (3amp, 4amp, 2mct, or 2mcp), the cadmium adducts are always more stable than the correspondent tin adducts probably due to the formation of cross-linking bonds in these compounds. Finally, of these 16 adducts, 14 showed antimicrobial activities against different bacterial and fungal strains.

ACS Style

Ahmed Gaber; Walaa F. Alsanie; Robson F. de Farias; Moamen S. Refat. Preparation and Thermogravimetric and Antimicrobial Investigation of Cd (II) and Sn (II) Adducts of Mercaptopyridine, Amino Triazole Derivatives, and Mercaptothiazoline Organic Ligand Moieties. Bioinorganic Chemistry and Applications 2021, 2021, 1 -10.

AMA Style

Ahmed Gaber, Walaa F. Alsanie, Robson F. de Farias, Moamen S. Refat. Preparation and Thermogravimetric and Antimicrobial Investigation of Cd (II) and Sn (II) Adducts of Mercaptopyridine, Amino Triazole Derivatives, and Mercaptothiazoline Organic Ligand Moieties. Bioinorganic Chemistry and Applications. 2021; 2021 ():1-10.

Chicago/Turabian Style

Ahmed Gaber; Walaa F. Alsanie; Robson F. de Farias; Moamen S. Refat. 2021. "Preparation and Thermogravimetric and Antimicrobial Investigation of Cd (II) and Sn (II) Adducts of Mercaptopyridine, Amino Triazole Derivatives, and Mercaptothiazoline Organic Ligand Moieties." Bioinorganic Chemistry and Applications 2021, no. : 1-10.

Journal article
Published: 15 April 2021 in Molecules
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Herein, we report the synthesis of eight new mononuclear and binuclear Co2+, Ni2+, Cu2+, and Zn2+ methoxy thiosemicarbazone (MTSC) complexes aiming at obtaining thiosemicarbazone complex with potent biological activity. The structure of the MTSC ligand and its metal complexes was fully characterized by elemental analysis, spectroscopic techniques (NMR, FTIR, UV-Vis), molar conductivity, thermogravimetric analysis (TG), and thermal differential analysis (DrTGA). The spectral and analytical data revealed that the obtained thiosemicarbazone-metal complexes have octahedral geometry around the metal center, except for the Zn2+-thiosemicarbazone complexes, which showed a tetrahedral geometry. The antibacterial and antifungal activities of the MTSC ligand and its (Co2+, Ni2+, Cu2+, and Zn2+) metal complexes were also investigated. Interestingly, the antibacterial activity of MTSC- metal complexes against examined bacteria was higher than that of the MTSC alone, which indicates that metal complexation improved the antibacterial activity of the parent ligand. Among different metal complexes, the MTSC- mono- and binuclear Cu2+ complexes showed significant antibacterial activity against Bacillus subtilis and Proteus vulgaris, better than that of the standard gentamycin drug. The in silico molecular docking study has revealed that the MTSC ligand could be a potential inhibitor for the oxidoreductase protein.

ACS Style

Ahmed Gaber; Moamen Refat; Arafa Belal; Ibrahim El-Deen; Nader Hassan; Rozan Zakaria; Majid Alhomrani; Abdulhakeem Alamri; Walaa Alsanie; Essa M. Saied. New Mononuclear and Binuclear Cu(II), Co(II), Ni(II), and Zn(II) Thiosemicarbazone Complexes with Potential Biological Activity: Antimicrobial and Molecular Docking Study. Molecules 2021, 26, 2288 .

AMA Style

Ahmed Gaber, Moamen Refat, Arafa Belal, Ibrahim El-Deen, Nader Hassan, Rozan Zakaria, Majid Alhomrani, Abdulhakeem Alamri, Walaa Alsanie, Essa M. Saied. New Mononuclear and Binuclear Cu(II), Co(II), Ni(II), and Zn(II) Thiosemicarbazone Complexes with Potential Biological Activity: Antimicrobial and Molecular Docking Study. Molecules. 2021; 26 (8):2288.

Chicago/Turabian Style

Ahmed Gaber; Moamen Refat; Arafa Belal; Ibrahim El-Deen; Nader Hassan; Rozan Zakaria; Majid Alhomrani; Abdulhakeem Alamri; Walaa Alsanie; Essa M. Saied. 2021. "New Mononuclear and Binuclear Cu(II), Co(II), Ni(II), and Zn(II) Thiosemicarbazone Complexes with Potential Biological Activity: Antimicrobial and Molecular Docking Study." Molecules 26, no. 8: 2288.