Scientific research plays a fundamental role in current medical practice and it is of great importance that medical students relate to it from the beginning of their professional career, since it generates multiple benefits that will be reflected during the course of their careers as university students and future professionals. However, getting involved in research during the undergraduate years is not always easy, as there are different obstacles and challenges that result in a reduced number of research students. Because of this, it is necessary to adopt appropriate strategies and measures to help facilitate this process, in order to foster the early development of essential skills that will facilitate responsible clinical practice. Knowing the evidence on this issue is fundamental to propose educational solutions depending on each context.

The brain-lung interaction can seriously affect patients with traumatic brain injury, triggering a vicious cycle that worsens patient prognosis. Although the mechanisms of the interaction are not fully elucidated, several hypotheses, notably the “blast injury” theory or “double hit” model, have been proposed and constitute the basis of its development and progression. The brain and lungs strongly interact via complex pathways from the brain to the lungs but also from the lungs to the brain. The main pulmonary disorders that occur after brain injuries are neurogenic pulmonary edema, acute respiratory distress syndrome, and ventilator-associated pneumonia, and the principal brain disorders after lung injuries include brain hypoxia and intracranial hypertension. All of these conditions are key considerations for management therapies after traumatic brain injury and need exceptional case-by-case monitoring to avoid neurological or pulmonary complications. This review aims to describe the history, pathophysiology, risk factors, characteristics, and complications of brain-lung and lung-brain interactions and the impact of different old and recent modalities of treatment in the context of traumatic brain injury.

End-of-life care is an increasingly relevant topic due to advances in biomedical research and the establishment of new disciplines in evidence-based medicine and bioethics. Euthanasia and assisted suicide are two terms widely discussed in medicine, which cause displeasure on many occasions and cause relief on others. The evolution of these terms and the events associated with their study have allowed the evaluation of cases that have established useful definitions for the legal regulation of palliative care and public policies in the different health systems. However, there are still many aspects to be elucidated and defined. Based on the above, this review aimed to compile relevant historical aspects on the evolution of euthanasia and assisted suicide, which will allow understanding the use and research of these terms.

In recent years, there has been a growing concern over questionable practices and a lack of rigor in scientific activities, particularly in health and medical sciences. Universities and research institutes are key players in the development of science, technology, and innovation. Academic institutions, whose primary mission is to generate and disseminate knowledge, bear the responsibility in many parts of the world to act as consultants and guardians of scientific integrity in health research. Then, universities and research institutes must act as guardians of the research and technological development process, utilizing methodological and operational evaluation tools to validate the rigor and quality of medical research. Meta-research is defined as the research of research itself. Some of the most important specific objectives of meta-research include the assessment of research relevance, the evaluation of evidence validity, and the exploration of scientific integrity. A significant portion of evidence in the medical and health sciences literature has been found to be redundant, misleading, or inconsistent. Although this issue is of great importance in global health, discussions about practical and tangible solutions remain fragmented and limited. The aim of this manuscript is to highlight the significance of employing meta-research within universities and research institutes as a tool to monitor scientific rigor and promote responsible practices in medical research.

Meta-research in biomedical science is crucial for ensuring rigour, relevance, and transparency in an era marked by the exponential growth of scientific publications. This study examines global and historical trends in meta-research activities within biomedicine and investigates their relationship with health, science, and human development indicators. A systematic analysis of 9633 publications from Scopus, Web of Science, and PubMed was conducted, focusing on publication volume, citation impact, and geographic distribution. Regression analyses reveal a significant positive association between meta-research activity and the Human Development Index (HDI), suggesting that meta-research contributes to societal advancement by enhancing evidence-based decision-making in health. However, no association was found between meta-research output and research and development (R&D) expenditure, reflecting the minimal resource requirements of secondary data-driven studies compared to primary or experimental research. Meta-research activity correlates positively with clinical trial completion, indicating its role in refining study designs and addressing evidence gaps. These findings highlight the importance of expanding meta-research in underrepresented regions to promote equity in scientific advancement and improve the reliability of biomedical knowledge. This result underscores the need for targeted support for meta-research, particularly in low- and middle-income countries with limited scientific infrastructure and resources for new knowledge generation.