The increased permeability of the lung microvascular endothelium is one critical initiation of acute lung injury (ALI). The disruption of vascular-endothelium integrity results in leakiness of the endothelial barrier and accumulation of protein-rich fluid in the alveoli. During ALI, increased endothelial-cell (EC) permeability is always companied by high frequency and amplitude of cytosolic Ca²⁺ oscillations. Mechanistically, cytosolic calcium oscillations include calcium release from internal stores and calcium entry via channels located in the cell membrane. Recently, numerous publications have shown substantial evidence that calcium-permeable channels play an important role in maintaining the integrity of the endothelium barrier function of the vessel wall in ALI. These novel endothelial signaling pathways are future targets for the treatment of lung injury. This short review focuses on the up-to-date research and provide insight into the contribution of calcium influx via ion channels to the disruption of lung microvascular endothelial-barrier function during ALI.

The purpose of this study is to explore the influence of virtual reality technology on college students' interest in sports learning. This paper applies virtual reality technology to table tennis teaching practice, and constructs a new teaching mode with teachers as the leading role and students as the main body. In this study, 19 non-sports major students were selected as subjects, and a single-subject experiment was conducted to evaluate the indicators of interest in sports situations in the pre-experiment and post-experiment stages in a four-week intervention experiment from June to July 2019. The results show that the use of virtual reality games in table tennis learning can improve students' interest in sports learning, learning attitude is more positive.