Carla Arruda

Dr. Carla Arruda

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Research Focus & Metrics

Academic Career Length

18Years (2009-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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16 December 2019 in Archiv der Pharmazie
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OTOzildéia S. Trefzger
Ozildéia S. Trefzger
NBNatália V. Barbosa
Natália V. Barbosa
RSRenata L. Scapolatempo
Renata L. Scapolatempo
ANAmarith R. das Neves
Amarith R. das Neves
MOMaria L. F. S. Ortale
Maria L. F. S. Ortale
ABAdriano C. M. Baroni
Adriano C. M. Baroni

23 August 2021 in Journal of Biophotonics
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GLGustavo Larios
Gustavo Larios
MRMatheus Ribeiro
Matheus Ribeiro
Carla ArrudaCarla Arruda
Carla Arruda
Samuel L. OliveiraSamuel L. Oliveira
Samuel L. Oliveira
TCThalita Canassa
Thalita Canassa
CCCícero Cena
Cícero Cena

1 March 2015 in Revista Brasileira de Farmacognosia
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Journal Article
Open access
LBLauriane S.S. Bosquiroli
Lauriane S.S. Bosquiroli
Daniel Pecoraro DemarqueDaniel Pecoraro Demarque
Daniel Pecoraro Demarque
YRYasmin S. Rizk
Yasmin S. Rizk
MCMarillin C. Cunha
Marillin C. Cunha
MMMaria Carolina S. Marques
Maria Carolina S. Marques
Carla ArrudaCarla Arruda
Carla Arruda
Piper angustifolium Lam., Piperaceae, popularly known as “matito”, “pimenta-de-macaco”, “pimenta-longa” or “jagurandi” in Brazil, has been commonly used in the treatment of cutaneous leishmaniasis-associated lesions, but there are few studies on the activity against visceral leishmaniasis-associated species. This study demonstrates the first in vitro antileishmanial activity of the P. angustifolium essential oil, of which the phytochemical profile showed the presence of sesquiterpenes and monoterpenes. The main compounds were spathulenol (23.8%) and caryophyllene oxide (13.1%). P. angustifolium essential oil was highly active [the half maximum inhibitory concentration=1.43μg/ml] against intracellular amastigotes of Leishmania infantum, the etiological agent of visceral leishmaniasis in the New and Old World. Activity was obtained 24h after addition of the oil (6.25–50μg/ml), with a reduction of 100% in the infection index at concentrations of 25 and 50μg/ml. P. angustifolium essential oil showed low cytotoxicity for mammalian fibroblasts and macrophages (the half maximum inhibitory concentration values of 31.67 and 48.22μg/ml, respectively), and it was 33 and 22 times more toxic to amastigotes than to mammalian cells, as indicated by selectivity indexes. The results demonstrated that P. angustifolium essential oil is a promising alternative for the study of potential drugs for visceral leishmaniasis

20 June 2016 in Molecules
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ECEduarda C. Costa
Eduarda C. Costa
TCTatiana B. Cassamale
Tatiana B. Cassamale
DCDiego B. Carvalho
Diego B. Carvalho
LBLauriane S. S. Bosquiroli
Lauriane S. S. Bosquiroli
MOMariáh Ojeda
Mariáh Ojeda
Carla ArrudaCarla Arruda
Carla Arruda
Sixteen 1,4-diaryl-1,2,3-triazole compounds 4–19 derived from the tetrahydrofuran neolignans veraguensin 1, grandisin 2, and machilin G 3 were tested against Leishmania (Leishmania) amazonensis intracellular amastigotes. Triazole compounds 4–19 were synthetized via Click Chemistry strategy by 1,3-dipolar cycloaddition between terminal acetylenes and aryl azides containing methoxy and methylenedioxy groups as substituents. Our results suggest that most derivatives were active against intracellular amastigotes, with IC50 values ranging from 4.4 to 32.7 µM. The index of molecular hydrophobicity (ClogP) ranged from 2.8 to 3.4, reflecting a lipophilicity/hydrosolubility rate suitable for transport across membranes, which may have resulted in the potent antileishmanial activity observed. Regarding structure-activity relationship (SAR), compounds 14 and 19, containing a trimethoxy group, were the most active (IC50 values of 5.6 and 4.4 µM, respectively), with low cytotoxicity on mammalian cells (SI = 14.1 and 10.6). These compounds induced nitric oxide production by the host macrophage cells, which could be suggested as the mechanism involved in the intracellular killing of parasites. These results would be useful for the planning of new derivatives with higher antileishmanial activities.

1 December 2014 in Memórias do Instituto Oswaldo Cruz
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YRYasmin Silva Rizk
Yasmin Silva Rizk
AFAlice Fischer
Alice Fischer
MCMarillin de Castro Cunha
Marillin de Castro Cunha
PRPatrik Oening Rodrigues
Patrik Oening Rodrigues
MMMaria Carolina Silva Marques
Maria Carolina Silva Marques
Carla ArrudaCarla Arruda
Carla Arruda
Immunocompromised patients may develop severe chronic anaemia when infected by human parvovirus B19 (B19V). However, this is not the case in human immunodeficiency virus (HIV)-infected patients with good adherence to highly active antiretroviral treatment (HAART). In this study, we investigated the clinical evolution of five HIV-infected patients receiving HAART who had B19V infections confirmed by serum polymerase chain reaction. Four of the patients were infected with genotype 1a strains and the remaining patient was infected with a genotype 3b strain. Anaemia was detected in three of the patients, but all patients recovered without requiring immunoglobulin and/or blood transfusions. In all cases, the attending physicians did not suspect the B19V infections. There was no apparent relationship between the infecting genotype and the clinical course. In the HAART era, B19V infections in HIV-positive patients may be limited, subtle or unapparent.

1 October 2009 in Revista da Sociedade Brasileira de Medicina Tropical
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AAAna Rachel Oliveira de Andrade
Ana Rachel Oliveira de Andrade
VNVânia Lúcia Brandão Nunes
Vânia Lúcia Brandão Nunes
EGEunice Aparecida Bianchi Galati
Eunice Aparecida Bianchi Galati
Carla ArrudaCarla Arruda
Carla Arruda
MSMirella Ferreira da Cunha Santos
Mirella Ferreira da Cunha Santos
RARicardo Braga Aquino
Ricardo Braga Aquino
The aims of this study were to carry out a serological survey of canine leishmaniasis and identify the phlebotomine fauna in the urban area of Bonito, Mato Grosso do Sul. The serological survey was conducted on a sample of 303 dogs, by means of the indirect immunofluorescence test. Phlebotomines were captured using automated light traps. The serological survey found that 30% of the dogs were seropositive, both from the center and from all districts of the town. A total of 2,772 specimens of phlebotomines were caught and the species most found was Lutzomyia longipalpis (90.4%), which corroborated its role as the vector of for canine visceral leishmaniasis in the region. Phlebotomines of the species Bichromomyia flaviscutellata (the main vector for Leishmania (Leishmania) amazonensis) and Nyssomyia whitmani (the vector for Leishmania (Viannia) brasiliensis) were also caught. The findings indicate the need for continuous epidemiological surveillance, with attention towards diminishing the vector breeding sites and the transmission of these diseases in that region.