Mary Anne Tablizo

Dr. Mary Anne Tablizo

Division of Pediatric Pulmonary and Sleep Medicine, Valley Children’s Hospital, Madera, CA 93636, USA

Research Focus & Metrics

Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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19 September 2021 in Children
Verified
Journal Article
Open access
PDF file
GUGino Urbano
Gino Urbano
BTBea Tablizo
Bea Tablizo
YMYoumna Moufarrej
Youmna Moufarrej
Mary Anne TablizoMary Anne Tablizo
Mary Anne Tablizo
MCMaida Lynn Chen
Maida Lynn Chen
Manisha WitmansManisha Witmans
Manisha Witmans
Obstructive sleep apnea (OSA) is a form of sleep-disordered breathing that affects up to 9.5% of the pediatric population. Untreated OSA is associated with several complications, including neurobehavioral sequelae, growth and developmental delay, cardiovascular dysfunction, and insulin resistance. Attention-deficit/hyperactivity disorder (ADHD) is among the neurobehavioral sequelae associated with OSA. This review aims to summarize the research on the relationship between OSA and ADHD and investigate the impacts of OSA treatment on ADHD symptoms. A literature search was conducted on electronic databases with the key terms: “attention deficit hyperactivity disorder” or “ADHD”, “obstructive sleep apnea” or “OSA”, “sleep disordered breathing”, and “pediatric” or “children”. Review of relevant studies showed adenotonsillectomy to be effective in the short-term treatment of ADHD symptoms. The success of other treatment options, including continuous positive airway pressure (CPAP), in treating ADHD symptoms in pediatric OSA patients has not been adequately evaluated. Further studies are needed to evaluate the long-term benefits of surgical intervention, patient factors that may influence treatment success, and the potential benefits of other OSA treatment methods for pediatric ADHD patients.

15 February 2022 in Children
Verified
Journal Article
Open access
PDF file
STSelena Thomas
Selena Thomas
SPShefali Patel
Shefali Patel
PGPrabhavathi Gummalla
Prabhavathi Gummalla
Mary Anne TablizoMary Anne Tablizo
Mary Anne Tablizo
CKCatherine Kier
Catherine Kier
Pediatric obstructive sleep apnea (OSA) has been shown to not only affect the quality of sleep, but also overall health in general. Untreated or inadequately treated OSA can lead to long-term sequelae involving cardiovascular, endothelial, metabolic, endocrine, neurocognitive, and psychological consequences. The physiological effects of pediatric OSA eventually become pathological. As the complex effects of pediatric OSA are discovered, they must be identified early so that healthcare providers can be better equipped to treat and even prevent them. Ultimately, adequate management of OSA improves overall quality of life.

24 February 2022 in Children
Verified
Journal Article
Open access
PDF file
MKMandip Singh Kang
Mandip Singh Kang
FMFan Mo
Fan Mo
Manisha WitmansManisha Witmans
Manisha Witmans
VSVicente Santiago
Vicente Santiago
Mary Anne TablizoMary Anne Tablizo
Mary Anne Tablizo
Obstructive sleep apnea in children has been linked with behavioral and neurocognitive problems, impaired growth, cardiovascular morbidity, and metabolic consequences. Diagnosing children at a young age can potentially prevent significant morbidity associated with OSA. Despite the importance of taking a comprehensive sleep history and performing thorough physical examination to screen for signs and symptoms of OSA, these findings alone are inadequate for definitively diagnosing OSA. In-laboratory polysomnography (PSG) remains the gold standard of diagnosing pediatric OSA. However, there are limitations related to the attended in-lab polysomnography, such as limited access to a sleep center, the specialized training involved in studying children, the laborious nature of the test and social/economic barriers, which can delay diagnosis and treatment. There has been increasing research about utilizing alternative methods of diagnosis of OSA in children including home sleep testing, especially with the emergence of wearable technology. In this article, we aim to look at the presentation, physical exam, screening questionnaires and current different modalities used to aid in the diagnosis of OSA in children.

15 March 2022 in Children
Verified
Journal Article
Open access
PDF file
ICIndira Chandrasekar
Indira Chandrasekar
Mary Anne TablizoMary Anne Tablizo
Mary Anne Tablizo
Manisha WitmansManisha Witmans
Manisha Witmans
JCJose Maria Cruz
Jose Maria Cruz
MCMarcus Cummins
Marcus Cummins
WEWendy Estrellado-Cruz
Wendy Estrellado-Cruz
Neonates have distinctive anatomic and physiologic features that predispose them to obstructive sleep apnea (OSA). The overall prevalence of neonatal OSA is unknown, although an increase in prevalence has been reported in neonates with craniofacial malformations, neurological disorders, and airway malformations. If remained unrecognized and untreated, neonatal OSA can lead to impaired growth and development, cardiovascular morbidity, and can even be life threatening. Polysomnography and direct visualization of the airway are essential diagnostic modalities in neonatal OSA. Treatment of neonatal OSA is based on the severity of OSA and associated co-morbidities. This may include medical and surgical interventions individualized for the affected neonate. Based on this, it is expected that infants with OSA have more significant healthcare utilization.

22 November 2021 in Children
Verified
Journal Article
Open access
PDF file
EGErica Gastelum
Erica Gastelum
MCMarcus Cummins
Marcus Cummins
ASAmitoj Singh
Amitoj Singh
MMMichael Montoya
Michael Montoya
GUGino Urbano
Gino Urbano
Mary Anne TablizoMary Anne Tablizo
Mary Anne Tablizo
Children with Down syndrome (DS) are at high risk for developing obstructive sleep apnea (OSA) compared to children without DS. The negative impact of OSA on health, behavior, and cognitive development in children with DS highlights the importance of timely and effective treatment. Due to the higher prevalence of craniofacial and airway abnormalities, obesity, and hypotonia in patients with DS, residual OSA can still occur after exhausting first-line options. While treatment commonly includes adenotonsillectomy (AT) and continuous positive airway pressure (CPAP) therapy, additional therapy such as medical management and/or adjuvant surgical procedures need to be considered in refractory OSA. Given the significant comorbidities secondary to untreated OSA in children with DS, such as cardiovascular and neurobehavioral consequences, more robust randomized trials in this patient population are needed to produce treatment guidelines separate from those for the general pediatric population of otherwise healthy children with OSA. Further studies are also needed to look at desensitization and optimization of CPAP use in patients with DS and OSA.

15 July 2022 in Children
Verified
Journal Article
Open access
PDF file
THTammarie Heit
Tammarie Heit
BTBea Tablizo
Bea Tablizo
MSMartina Isabel Pagulayan Salud
Martina Isabel Pagulayan Salud
FMFan Mo
Fan Mo
MKMandip Kang
Mandip Kang
Manisha WitmansManisha Witmans
Manisha Witmans
Obstructive sleep apnea (OSA) is a clinical disorder within the spectrum of sleep-related breathing disorders (SRDB) which is used to describe abnormal breathing during sleep resulting in gas exchange abnormalities and/or sleep disruption. OSA is a highly prevalent disorder with associated sequelae across multiple physical domains, overlapping with other chronic diseases, affecting development in children as well as increased health care utilization. More precise and personalized approaches are required to treat the complex constellation of symptoms with its associated comorbidities since not all children are cured by surgery (removal of the adenoids and tonsils). Given that dentists manage the teeth throughout the lifespan and have an important understanding of the anatomy and physiology involved with the airway from a dental perspective, it seems reasonable that better understanding and management from their field will give the opportunity to provide better integrated and optimized outcomes for children affected by OSA. With the emergence of therapies such as mandibular advancement devices and maxillary expansion, etc., dentists can be involved in providing care for OSA along with sleep medicine doctors. Furthermore, the evolving role of myofunctional therapy may also be indicated as adjunctive therapy in the management of children with OSA. The objective of this article is to discuss the important role of dentists and the collaborative approach between dentists, allied dental professionals such as myofunctional therapists, and sleep medicine specialists for identifying and managing children with OSA. Prevention and anticipatory guidance will also be addressed.