Journal of Medical Internet Research - International Scientific Journal for Medical Research, Information and Communication on the Internet #Preprint #PeerReviewMe: Warning: This is a unreviewed preprint. Readers are warned that the document has not been peer-reviewed by expert/patient reviewers or an academic editor, may contain misleading claims, and is likely to undergo changes before final publication, if accepted, or may have been rejected/withdrawn. Readers with interest and expertise are encouraged to sign up as peer-reviewer, if the paper is within an open peer-review period. Please cite this preprint only for review purposes or for grant applications and CVs (if you are the author). Background: Stroke is one of the most common diseases that cause mortality. Detecting the risk of stroke for individuals is critical yet challenging because of a large number of risk factors for stroke. Objective: To address the limitation of ineffective feature selection in existing research on stroke risk detection, we propose a new feature selection method called Weighting- and Ranking-based Hybrid Feature Selection (WRHFS) to select important risk factors for detecting ischemic stroke. Methods: WRHFS integrates the strengths of various filter algorithms by following the principle of a wrapper approach. We employed a variety of filter-based feature selection models as the candidate set, including standard deviation, Pearson correlation coefficient, Fisher score, information gain, RELIEF, and Chi-squared, and used sensitivity, specificity, accuracy, and Youden’s index as performance metrics to evaluate the proposed method. Results: This study chooses 792 samples from the electronic records of 13,421 patients in a community hospital. Each sample includes 28 features (the 24 blood test features and the 4 demographic features). The results of evaluation show that the proposed method selects 9 important features out of the original 28 features and significantly outperforms baseline methods. Their cumulative contribution was 0.51. The WRHFS method achieves sensitivity of 82.7% (329/398), specificity of 80.4% (317/394), the classification accuracy of 81.5% (645/792), and Youden’s Index of 0.63 using only the top 9 features. We also present a chart for visualizing the risk of having ischemic strokes. Conclusions: This research proposes, develops, and evaluates a new feature selection method for identifying most important features for building effective and parsimonious models for stroke risk detection. The findings of this research provide several novel research contributions and practical implications.