Validation is arguably the bottleneck in the diffusion magnetic resonance imaging (MRI) community. This paper evaluates and compares 20 algorithms for recovering the local intra-voxel fiber structure from diffusion MRI data and is based on the results of the “HARDI reconstruction challenge” organized in the context of the “ISBI 2012” conference. Evaluated methods encompass a mixture of classical techniques well known in the literature such as diffusion tensor, Q-Ball and diffusion spectrum imaging, algorithms inspired by the recent theory of compressed sensing and also brand new approaches proposed for the first time at this contest. To quantitatively compare the methods under controlled conditions, two datasets with known ground-truth were synthetically generated and two main criteria were used to evaluate the quality of the reconstructions in every voxel: correct assessment of the number of fiber populations and angular accuracy in their orientation. This comparative study investigates the behavior of every algorithm with varying experimental conditions and highlights strengths and weaknesses of each approach. This information can be useful not only for enhancing current algorithms and develop the next generation of reconstruction methods, but also to assist physicians in the choice of the most adequate technique for their studies.

The use of the discrete wavelet transform (DWT) for embedded lossy image compression is now well established. One of the possible implementations of the DWT is the lifting scheme (LS). Because perfect reconstruction is granted by the structure of the LS, nonlinear transforms can be used, allowing efficient lossless compression as well. The integer wavelet transform (IWT) is one of them. This is an interesting alternative to the DWT because its rate-distortion performance is similar and the differences can be predicted. This topic is investigated in a theoretical framework. A model of the degradations caused by the use of the IWT instead of the DWT for lossy compression is presented. The rounding operations are modeled as additive noise. The noise are then propagated through the LS structure to measure their impact on the reconstructed pixels. This methodology is verified using simulations with random noise as input. It predicts accurately the results obtained using images compressed by the well-known EZW algorithm. Experiment are also performed to measure the difference in terms of bit rate and visual quality. This allows to a better understanding of the impact of the IWT when applied to lossy image compression.

Introduction In patients with multiple sclerosis (MS), conventional magnetic resonance imaging (MRI) provides only limited insights into the nature of brain damage with modest clinic-radiological correlation. In this study, we applied recent advances in MRI techniques to study brain microstructural alterations in early relapsing-remitting MS (RRMS) patients with minor deficits. Further, we investigated the potential use of advanced MRI to predict functional performances in these patients. Methods Brain relaxometry (T1, T2, T2*) and magnetization transfer MRI were performed at 3T in 36 RRMS patients and 18 healthy controls (HC). Multicontrast analysis was used to assess for microstructural alterations in normal-appearing (NA) tissue and lesions. A generalized linear model was computed to predict clinical performance in patients using multicontrast MRI data, conventional MRI measures as well as demographic and behavioral data as covariates. Results Quantitative T2 and T2* relaxometry were significantly increased in temporal normal-appearing white matter (NAWM) of patients compared to HC, indicating subtle microedema (P = 0.03 and 0.004). Furthermore, significant T1 and magnetization transfer ratio (MTR) variations in lesions (mean T1 z-score: 4.42 and mean MTR z-score: −4.09) suggested substantial tissue loss. Combinations of multicontrast and conventional MRI data significantly predicted cognitive fatigue (P = 0.01, Adj-R² = 0.4), attention (P = 0.0005, Adj-R² = 0.6), and disability (P = 0.03, Adj-R² = 0.4). Conclusion Advanced MRI techniques at 3T, unraveled the nature of brain tissue damage in early MS and substantially improved clinical–radiological correlations in patients with minor deficits, as compared to conventional measures of disease.