Dr. MAIRA HUERTA-REYES
Mexican Social Security Institute, Mexico City, Ciudad de México, Mexico
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Academic Career Length
16Years (2011-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 November 2011 in Phytomedicine
Journal Article
MHM. Herrera-Ruiz
M. Herrera-Ruiz
AZA. Zamilpa
A. Zamilpa
Manasés Gonzalez-CortazarRRRicardo Reyes-Chilpa
Ricardo Reyes-ChilpaELE. León
E. León
MAIRA HUERTA-REYES +2
Journal Article
MAIRA HUERTA-REYESRTRosario Tavera-Hernandez
Rosario Tavera-HernandezJAJ. Javier Alvarado-Sansininea
J. Javier Alvarado-SansinineaMJManuel Jimenez-Estrada
Manuel Jimenez-EstradaIn Mexico, Diabetes mellitus (DM) is a serious health problem, and although the current pharmacological treatments for DM such as insulin and oral hypoglycemics are available, the Mexican population continues to use medicinal plants in the treatment of DM. The antidiabetic properties of the plant species that belong to the Cucurbitaceae family has already been recognized worldwide. Since Mexico is one of the most important centers of diversity of Cucurbitaceae, the present work contributes to the review of the most used species of Cucurbitaceae in the treatment of DM in Mexico. The reviewed species (Cucurbita ficifolia, C. maxima, C. moschata, C. pepo, Ibervillea sonorae, Sechium edule, Citrullus lanatus, Cucumis melo, and C. sativus) revealed that the antidiabetic effects exerted are effective in a number of mechanisms involved in the complex pathogenesis of DM: hypoglycemic, antioxidant, anti-inflammatory, anti-obesity, protective effects on diverse organs and cells, as well as in the control of dyslipidemias; furthermore, the select species of the Cucurbitaceae family could also be essential components of diets for the control of DM in patients with the disease. Thus, the Cucurbitaceae species selected in the present work represent a source of antidiabetic agents that perhaps establish the bases for novel clinical treatments.
Journal Article
RTRosario Tavera-Hernandez
Rosario Tavera-HernandezMJManuel Jimenez-Estrada
Manuel Jimenez-EstradaJAJ. Javier Alvarado-Sansininea
J. Javier Alvarado-SansinineaMAIRA HUERTA-REYESDiabetes mellitus (DM) is considered one of the major health diseases worldwide, one that requires immediate alternatives to allow treatments for DM to be more effective and less costly for patients and also for health-care systems. Recent approaches propose treatments for DM based on that; in addition to focusing on reducing hyperglycemia, they also consider multitargets, as in the case of plants. Among these, we find the plant known as chia to be highlighted, a crop native to Mexico and one cultivated in Mesoamerica from pre-Hispanic times. The present work contributes to the review of the antidiabetic effects of chia for the treatment of DM. The antidiabetic effects of chia are effective in different mechanisms involved in the complex pathogenesis of DM, including hypoglycemic, antioxidant, and anti-inflammatory mechanisms, and the inhibition of the enzymes α-glucosidase and α-amylase, as well as in the prevention of the risk of cardiovascular disease. The tests reviewed included 16 in vivo assays on rodent models, 13 clinical trials, and 4 in vitro tests. Furthermore, chia represents advantages over other natural products due to its availability and its acceptance and, in addition, as a component of the daily diet worldwide, especially due to its omega-3 fatty acids and its high concentration of dietary fiber. Thus, chia in the present work represents a source of antidiabetic agents that would perhaps be useful in novel clinical treatments.
1 March 2013 in Journal of Ethnopharmacology
Journal Article
MAIRA HUERTA-REYESMHMaribel Herrera-Ruiz
Maribel Herrera-Ruiz
Manasés Gonzalez-CortazarAZAlejandro Zamilpa
Alejandro Zamilpa
ELEsther León
Esther León
JTJaime Tortoriello
Jaime Tortoriello +2
23 November 2012 in BMC Cancer
Journal Article
AAArturo Aguilar-Rojas
Arturo Aguilar-RojasMAIRA HUERTA-REYESGMGuadalupe Maya-Núñez
Guadalupe Maya-NúñezFAFabián Arechavaleta-Velásco
Fabián Arechavaleta-VeláscoPCP Michael Conn
P Michael ConnJVJesús Valdés
Jesús Valdés +1
Gonadotropin-releasing hormone (GnRH) and its receptor (GnRHR) are both expressed by a number of malignant tumors, including those of the breast. In the latter, both behave as potent inhibitors of invasion. Nevertheless, the signaling pathways whereby the activated GnRH/GnRHR system exerts this effect have not been clearly established. In this study, we provide experimental evidence that describes components of the mechanism(s) whereby GnRH inhibits breast cancer cell invasion.
Journal Article
MJManuel Jimenez-Estrada
Manuel Jimenez-EstradaMAIRA HUERTA-REYESRTRosario Tavera-Hernandez
Rosario Tavera-HernandezJAJ. Javier Alvarado-Sansininea
J. Javier Alvarado-SansinineaAAAna Berenice Alvarez
Ana Berenice AlvarezDiabetes mellitus (DM) is cited as a serious worldwide health problem that occupies second place in causes of annual mortality in Mexico. Among Mexican flora, nearly 300 plant species have been employed as hypoglycemic in popular use. Thus, their study entertains great relevance In this context, this work contributes a clear and timely review of the plant species utilized in Traditional Mexican Medicine and experimental biological models in which not only have the hypoglycemic properties of the extracts and the isolated compounds been considered, but also the anti-inflammatory and antioxidant properties, taking into account an integral focus based on the complex mechanisms involved in the pathogenesis and physiopathology of DM. Among the species reviewed, we highlight Psacalium decompositum (Asteraceae), due to the potent hypoglycemic, anti-inflammatory, and antioxidant activity of the sesquiterpenes identified as majority compounds isolated from the root, such as cacalol and cacalone that also possess the capacity of increasing insulin levels. In this manner, the present manuscript attempts to contribute necessary information for the future study of bioactive molecules that are useful in the treatment of DM, as well as also being a contribution to the knowledge and diffusion of Mexican Traditional Medicine.
About Me
Biologist and PhD in Biomedical Sciences from UNAM. I have worked as an Industrial Property Specialist in Patent Biotechnology at the Mexican Institute of Industrial Property. I am currently a researcher at the UIM in Nephrological Diseases at the Specialty Hospital, at the CMN S-XXI, and at the IMSS, where I focus on the study of Mexican plants and their potential role in the treatment of chronic diseases and the subsequent development of phytomedicines for clinical application, as well as on the industrial property related to the protection of these products. Therefore, my line of research proposes scientific alternatives for the treatment of diseases suffered by the Mexican population, based on a native natural resource. My main work tools consist of research in herbaria and online databases for obtaining plants as raw materials, chemical analysis for the identification and quantification of major compounds (chromatographic techniques), evaluation in biological activity assays (in vivo, in vitro), and patent protection in the subject and method categories.
My professional activities also include supervising undergraduate and graduate theses within the framework of international interdisciplinary collaborations and teaching specific topics for the writing and development of research projects in Biomedical Sciences. My scientific output includes original research articles, review articles, opinion pieces, popular articles, books, book chapters, and patents. I have also been