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Robin Kobbe
First Department of Medicine, Division of Infectious Diseases, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany

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Case report
Published: 30 June 2021 in Children
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Critical Coronavirus disease 2019 (COVID-19) developed in a 7-year-old girl with a history of dystrophy, microcephaly, and central hypothyroidism. Starting with gastrointestinal symptoms, the patient developed severe myocarditis followed by progressive multiple organ failure complicated by Pseudomonas aeruginosa bloodstream infection. Intensive care treatment consisting of invasive ventilation, drainage of pleural effusion, and high catecholamine therapy could not prevent the progression of heart failure, leading to the implantation of venoarterial extracorporeal life support (VA-ECLS) and additional left ventricle support catheter (Impella® pump). Continuous venovenous hemofiltration (CVVH) and extracorporeal hemadsorption therapy (CytoSorb®) were initiated. Whole exome sequencing revealed a mutation of unknown significance in DExH-BOX helicase 30 (DHX30), a gene encoding a RNA helicase. COVID-19 specific antiviral and immunomodulatory treatment did not lead to viral clearance or control of hyperinflammation resulting in the patient’s death on extracorporeal life support-(ECLS)-day 20. This fatal case illustrates the potential severity of pediatric COVID-19 and suggests further evaluation of antiviral treatment strategies and vaccination programs for children.

ACS Style

Sofia Apostolidou; Theresa Harbauer; Peter Lasch; Daniel Biermann; Maja Hempel; Marc Lütgehetmann; Susanne Pfefferle; Jochen Herrmann; André Rüffer; Konrad Reinshagen; Rainer Kozlik-Feldmann; Anna Gieras; Inga Kniep; Jun Oh; Dominique Singer; Chinedu Ebenebe; Robin Kobbe. Fatal COVID-19 in a Child with Persistence of SARS-CoV-2 Despite Extensive Multidisciplinary Treatment: A Case Report. Children 2021, 8, 564 .

AMA Style

Sofia Apostolidou, Theresa Harbauer, Peter Lasch, Daniel Biermann, Maja Hempel, Marc Lütgehetmann, Susanne Pfefferle, Jochen Herrmann, André Rüffer, Konrad Reinshagen, Rainer Kozlik-Feldmann, Anna Gieras, Inga Kniep, Jun Oh, Dominique Singer, Chinedu Ebenebe, Robin Kobbe. Fatal COVID-19 in a Child with Persistence of SARS-CoV-2 Despite Extensive Multidisciplinary Treatment: A Case Report. Children. 2021; 8 (7):564.

Chicago/Turabian Style

Sofia Apostolidou; Theresa Harbauer; Peter Lasch; Daniel Biermann; Maja Hempel; Marc Lütgehetmann; Susanne Pfefferle; Jochen Herrmann; André Rüffer; Konrad Reinshagen; Rainer Kozlik-Feldmann; Anna Gieras; Inga Kniep; Jun Oh; Dominique Singer; Chinedu Ebenebe; Robin Kobbe. 2021. "Fatal COVID-19 in a Child with Persistence of SARS-CoV-2 Despite Extensive Multidisciplinary Treatment: A Case Report." Children 8, no. 7: 564.

Communication
Published: 12 April 2021 in Viruses
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So far, only a few reports about reinfections with SARS-CoV-2 have been published, and they often lack detailed immunological and virological data. We report about a SARS-CoV-2 reinfection with a genetically distinct SARS-CoV-2 variant in an immunocompetent female healthcare worker that has led to a mild disease course. No obvious viral escape mutations were observed in the second virus variant. The infectious virus was shed from the patient during the second infection episode despite the presence of neutralizing antibodies in her blood. Our data indicate that a moderate immune response after the first infection, but not a viral escape, did allow for reinfection and live virus shedding.

ACS Style

Thomas Brehm; Susanne Pfefferle; Ronald von Possel; Robin Kobbe; Dominik Nörz; Stefan Schmiedel; Adam Grundhoff; Flaminia Olearo; Petra Emmerich; Alexis Robitaille; Thomas Günther; Platon Braun; Gabriele Andersen; Johannes Knobloch; Marylyn Addo; Ansgar Lohse; Martin Aepfelbacher; Nicole Fischer; Julian Schulze Zur Wiesch; Marc Lütgehetmann. SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies. Viruses 2021, 13, 661 .

AMA Style

Thomas Brehm, Susanne Pfefferle, Ronald von Possel, Robin Kobbe, Dominik Nörz, Stefan Schmiedel, Adam Grundhoff, Flaminia Olearo, Petra Emmerich, Alexis Robitaille, Thomas Günther, Platon Braun, Gabriele Andersen, Johannes Knobloch, Marylyn Addo, Ansgar Lohse, Martin Aepfelbacher, Nicole Fischer, Julian Schulze Zur Wiesch, Marc Lütgehetmann. SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies. Viruses. 2021; 13 (4):661.

Chicago/Turabian Style

Thomas Brehm; Susanne Pfefferle; Ronald von Possel; Robin Kobbe; Dominik Nörz; Stefan Schmiedel; Adam Grundhoff; Flaminia Olearo; Petra Emmerich; Alexis Robitaille; Thomas Günther; Platon Braun; Gabriele Andersen; Johannes Knobloch; Marylyn Addo; Ansgar Lohse; Martin Aepfelbacher; Nicole Fischer; Julian Schulze Zur Wiesch; Marc Lütgehetmann. 2021. "SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies." Viruses 13, no. 4: 661.

Journal article
Published: 06 April 2021 in Pathogens
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The current COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). A better understanding of its immunogenicity can be important for the development of improved diagnostics, therapeutics, and vaccines. Here, we report the longitudinal analysis of three COVID-19 patients with moderate (#1) and mild disease (#2 and #3). Antibody serum responses were analyzed using spike glycoprotein enzyme linked immunosorbent assay (ELISA), full-proteome peptide, and glycan microarrays. ELISA immunoglobulin A, G, and M (IgA, IgG, and IgM) signals increased over time for individuals #1 and #2, whereas #3 only showed no clear positive IgG and IgM result. In contrast, peptide microarrays showed increasing IgA/G signal intensity and epitope spread only in the moderate patient #1 over time, whereas early but transient IgA and stable IgG responses were observed in the two mild cases #2 and #3. Glycan arrays showed an interaction of antibodies to fragments of high-mannose and core N-glycans, present on the viral shield. In contrast to protein ELISA, microarrays allow for a deeper understanding of IgA, IgG, and IgM antibody responses to specific epitopes of the whole proteome and glycans of SARS-CoV-2 in parallel. In the future, this may help to better understand and to monitor vaccination programs and monoclonal antibodies as therapeutics.

ACS Style

Jasmin Heidepriem; Christine Dahlke; Robin Kobbe; René Santer; Till Koch; Anahita Fathi; Bruna Seco; My Ly; Stefan Schmiedel; Dorothee Schwinge; Sonia Serna; Katrin Sellrie; Niels-Christian Reichardt; Peter Seeberger; Marylyn Addo; Felix Loeffler; on behalf of the ID-UKE COVID-19 Study Group. Longitudinal Development of Antibody Responses in COVID-19 Patients of Different Severity with ELISA, Peptide, and Glycan Arrays: An Immunological Case Series. Pathogens 2021, 10, 438 .

AMA Style

Jasmin Heidepriem, Christine Dahlke, Robin Kobbe, René Santer, Till Koch, Anahita Fathi, Bruna Seco, My Ly, Stefan Schmiedel, Dorothee Schwinge, Sonia Serna, Katrin Sellrie, Niels-Christian Reichardt, Peter Seeberger, Marylyn Addo, Felix Loeffler, on behalf of the ID-UKE COVID-19 Study Group. Longitudinal Development of Antibody Responses in COVID-19 Patients of Different Severity with ELISA, Peptide, and Glycan Arrays: An Immunological Case Series. Pathogens. 2021; 10 (4):438.

Chicago/Turabian Style

Jasmin Heidepriem; Christine Dahlke; Robin Kobbe; René Santer; Till Koch; Anahita Fathi; Bruna Seco; My Ly; Stefan Schmiedel; Dorothee Schwinge; Sonia Serna; Katrin Sellrie; Niels-Christian Reichardt; Peter Seeberger; Marylyn Addo; Felix Loeffler; on behalf of the ID-UKE COVID-19 Study Group. 2021. "Longitudinal Development of Antibody Responses in COVID-19 Patients of Different Severity with ELISA, Peptide, and Glycan Arrays: An Immunological Case Series." Pathogens 10, no. 4: 438.

Journal article
Published: 01 February 2021 in Microbial Genomics
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Human tuberculosis (TB) is caused by members of the Mycobacterium tuberculosis complex (MTBC). The MTBC comprises several human-adapted lineages known as M. tuberculosis sensu stricto, as well as two lineages (L5 and L6) traditionally referred to as Mycobacterium africanum . Strains of L5 and L6 are largely limited to West Africa for reasons unknown, and little is known of their genomic diversity, phylogeography and evolution. Here, we analysed the genomes of 350 L5 and 320 L6 strains, isolated from patients from 21 African countries, plus 5 related genomes that had not been classified into any of the known MTBC lineages. Our population genomic and phylogeographical analyses showed that the unclassified genomes belonged to a new group that we propose to name MTBC lineage 9 (L9). While the most likely ancestral distribution of L9 was predicted to be East Africa, the most likely ancestral distribution for both L5 and L6 was the Eastern part of West Africa. Moreover, we found important differences between L5 and L6 strains with respect to their phylogeographical substructure and genetic diversity. Finally, we could not confirm the previous association of drug-resistance markers with lineage and sublineages. Instead, our results indicate that the association of drug resistance with lineage is most likely driven by sample bias or geography. In conclusion, our study sheds new light onto the genomic diversity and evolutionary history of M. africanum , and highlights the need to consider the particularities of each MTBC lineage for understanding the ecology and epidemiology of TB in Africa and globally.

ACS Style

Mireia Coscolla; Sebastien Gagneux; Fabrizio Menardo; Chloé Loiseau; Paula Ruiz-Rodriguez; Sonia Borrell; Isaac Darko Otchere; Adwoa Asante-Poku; Prince Asare; Leonor Sánchez-Busó; Florian Gehre; C. N’Dira Sanoussi; Martin Antonio; Dissou Affolabi; Janet Fyfe; Patrick Beckert; Stefan Niemann; Abraham S. Alabi; Martin P. Grobusch; Robin Kobbe; Julian Parkhill; Christian Beisel; Lukas Fenner; Erik C. Böttger; Conor J. Meehan; Simon R. Harris; Bouke C. de Jong; Dorothy Yeboah-Manu; Daniela Brites. Phylogenomics of Mycobacterium africanum reveals a new lineage and a complex evolutionary history. Microbial Genomics 2021, 7, 000477 .

AMA Style

Mireia Coscolla, Sebastien Gagneux, Fabrizio Menardo, Chloé Loiseau, Paula Ruiz-Rodriguez, Sonia Borrell, Isaac Darko Otchere, Adwoa Asante-Poku, Prince Asare, Leonor Sánchez-Busó, Florian Gehre, C. N’Dira Sanoussi, Martin Antonio, Dissou Affolabi, Janet Fyfe, Patrick Beckert, Stefan Niemann, Abraham S. Alabi, Martin P. Grobusch, Robin Kobbe, Julian Parkhill, Christian Beisel, Lukas Fenner, Erik C. Böttger, Conor J. Meehan, Simon R. Harris, Bouke C. de Jong, Dorothy Yeboah-Manu, Daniela Brites. Phylogenomics of Mycobacterium africanum reveals a new lineage and a complex evolutionary history. Microbial Genomics. 2021; 7 (2):000477.

Chicago/Turabian Style

Mireia Coscolla; Sebastien Gagneux; Fabrizio Menardo; Chloé Loiseau; Paula Ruiz-Rodriguez; Sonia Borrell; Isaac Darko Otchere; Adwoa Asante-Poku; Prince Asare; Leonor Sánchez-Busó; Florian Gehre; C. N’Dira Sanoussi; Martin Antonio; Dissou Affolabi; Janet Fyfe; Patrick Beckert; Stefan Niemann; Abraham S. Alabi; Martin P. Grobusch; Robin Kobbe; Julian Parkhill; Christian Beisel; Lukas Fenner; Erik C. Böttger; Conor J. Meehan; Simon R. Harris; Bouke C. de Jong; Dorothy Yeboah-Manu; Daniela Brites. 2021. "Phylogenomics of Mycobacterium africanum reveals a new lineage and a complex evolutionary history." Microbial Genomics 7, no. 2: 000477.

Chapter
Published: 26 November 2020 in Psychiatrie und Psychotherapie des Kindes- und Jugendalters
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Schon immer haben Parasiten den Menschen begleitet und sich dabei gegenseitig beeinflusst und somit die Evolution geprägt. Parasitäre Erkrankungen kommen zwar in allen Klimazonen vor, jedoch zählen die meisten und relevantesten Parasitosen heute zu den oft vernachlässigten Tropenerkrankungen, die auch aufgrund von Armut und damit verbundenen hygienischen Bedingungen meist in benachteiligten Bevölkerungsgruppen anzutreffen sind. Neben Plasmodien, den Erregern der Malaria, sind weitere Parasiten speziell bei Kindern und Jugendlichen von besonderer Bedeutung. Durch vermehrte Reiseaktivität von Kindern, Verwandtenbesuch von Migranten, sowie Zustrom von Geflüchteten in einer globalen Gesellschaft müssen Kinderärzte heute mit den klinischen Symptomen nichtendemischer Infektionskrankheiten vertraut sein. Das Kapitel gibt einen Überblick über die wichtigsten Erreger, die Pathogenese von Krankheitsbildern bei Kindern und Jugendlichen, Diagnostik und Therapie und soll auch einen Einblick in Bekämpfungsstrategien und Forschungsansätze liefern.

ACS Style

Robin Kobbe. Protozoen und Helminthen. Psychiatrie und Psychotherapie des Kindes- und Jugendalters 2020, 1387 -1418.

AMA Style

Robin Kobbe. Protozoen und Helminthen. Psychiatrie und Psychotherapie des Kindes- und Jugendalters. 2020; ():1387-1418.

Chicago/Turabian Style

Robin Kobbe. 2020. "Protozoen und Helminthen." Psychiatrie und Psychotherapie des Kindes- und Jugendalters , no. : 1387-1418.

Journal article
Published: 10 November 2020 in Journal of Experimental Medicine
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The identification and characterization of rare immune cell populations in humans can be facilitated by their growth advantage in the context of specific genetic diseases. Here, we use autoimmune lymphoproliferative syndrome to identify a population of FAS-controlled TCRαβ+ T cells. They include CD4+, CD8+, and double-negative T cells and can be defined by a CD38+CD45RA+T-BET− expression pattern. These unconventional T cells are present in healthy individuals, are generated before birth, are enriched in lymphoid tissue, and do not expand during acute viral infection. They are characterized by a unique molecular signature that is unambiguously different from other known T cell differentiation subsets and independent of CD4 or CD8 expression. Functionally, FAS-controlled T cells represent highly proliferative, noncytotoxic T cells with an IL-10 cytokine bias. Mechanistically, regulation of this physiological population is mediated by FAS and CTLA4 signaling, and its survival is enhanced by mTOR and STAT3 signals. Genetic alterations in these pathways result in expansion of FAS-controlled T cells, which can cause significant lymphoproliferative disease.

ACS Style

Maria Elena Maccari; Sebastian Fuchs; Patrick Kury; Geoffroy Andrieux; Simon Völkl; Bertram Bengsch; Myriam Ricarda Lorenz; Maximilian Heeg; Jan Rohr; Sabine Jägle; Carla N. Castro; Miriam Groß; Ursula Warthorst; Christoph König; Ilka Fuchs; Carsten Speckmann; Julian Thalhammer; Friedrich G. Kapp; Markus G. Seidel; Gregor Dückers; Stefan Schönberger; Catharina Schütz; Marita Führer; Robin Kobbe; Dirk Holzinger; Christian Klemann; Petr Smisek; Stephen Owens; Gerd Horneff; Reinhard Kolb; Nora Naumann-Bartsch; Maurizio Miano; Julian Staniek; Marta Rizzi; Tomas Kalina; Pascal Schneider; Anika Erxleben; Rolf Backofen; Arif Ekici; Charlotte M. Niemeyer; Klaus Warnatz; Bodo Grimbacher; Hermann Eibel; Andreas Mackensen; Andreas Philipp Frei; Klaus Schwarz; Melanie Boerries; Stephan Ehl; Anne Rensing-Ehl. A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS. Journal of Experimental Medicine 2020, 218, 1 .

AMA Style

Maria Elena Maccari, Sebastian Fuchs, Patrick Kury, Geoffroy Andrieux, Simon Völkl, Bertram Bengsch, Myriam Ricarda Lorenz, Maximilian Heeg, Jan Rohr, Sabine Jägle, Carla N. Castro, Miriam Groß, Ursula Warthorst, Christoph König, Ilka Fuchs, Carsten Speckmann, Julian Thalhammer, Friedrich G. Kapp, Markus G. Seidel, Gregor Dückers, Stefan Schönberger, Catharina Schütz, Marita Führer, Robin Kobbe, Dirk Holzinger, Christian Klemann, Petr Smisek, Stephen Owens, Gerd Horneff, Reinhard Kolb, Nora Naumann-Bartsch, Maurizio Miano, Julian Staniek, Marta Rizzi, Tomas Kalina, Pascal Schneider, Anika Erxleben, Rolf Backofen, Arif Ekici, Charlotte M. Niemeyer, Klaus Warnatz, Bodo Grimbacher, Hermann Eibel, Andreas Mackensen, Andreas Philipp Frei, Klaus Schwarz, Melanie Boerries, Stephan Ehl, Anne Rensing-Ehl. A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS. Journal of Experimental Medicine. 2020; 218 (2):1.

Chicago/Turabian Style

Maria Elena Maccari; Sebastian Fuchs; Patrick Kury; Geoffroy Andrieux; Simon Völkl; Bertram Bengsch; Myriam Ricarda Lorenz; Maximilian Heeg; Jan Rohr; Sabine Jägle; Carla N. Castro; Miriam Groß; Ursula Warthorst; Christoph König; Ilka Fuchs; Carsten Speckmann; Julian Thalhammer; Friedrich G. Kapp; Markus G. Seidel; Gregor Dückers; Stefan Schönberger; Catharina Schütz; Marita Führer; Robin Kobbe; Dirk Holzinger; Christian Klemann; Petr Smisek; Stephen Owens; Gerd Horneff; Reinhard Kolb; Nora Naumann-Bartsch; Maurizio Miano; Julian Staniek; Marta Rizzi; Tomas Kalina; Pascal Schneider; Anika Erxleben; Rolf Backofen; Arif Ekici; Charlotte M. Niemeyer; Klaus Warnatz; Bodo Grimbacher; Hermann Eibel; Andreas Mackensen; Andreas Philipp Frei; Klaus Schwarz; Melanie Boerries; Stephan Ehl; Anne Rensing-Ehl. 2020. "A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS." Journal of Experimental Medicine 218, no. 2: 1.

Other
Published: 16 June 2020
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ObjectivesWe used viral genomics to deeply analyze the first SARS-CoV-2 infection clusters in the metropolitan region of Hamburg, Germany. Epidemiological analysis and contact tracing together with a thorough investigation of virus variant patterns revealed low and high infection dose transmissions to be involved in transmission events.MethodsInfection control measures were applied to follow up contract tracing. Metagenomic RNA- and SARS-CoV-2 amplicon sequencing was performed from 25 clinical samples for sequence analysis and variant calling.ResultsThe index patient acquired SARS-CoV-2 in Italy and after his return to Hamburg transmitted it to 2 out of 132 contacts. Virus genomics and variant pattern clearly confirms the initial local cluster. We identify frequent single nucleotide polymorphisms at positions 241, 3037, 14408, 23403 and 28881 previously described in Italian sequences and now considered as one major genotype in Europe. While the index patient showed a single nucleotide polymorphism only one variant was transmitted to the recipients. Different to the initial cluster, we observed in household clusters occurring at the time in Hamburg also intra-host viral species transmission events.ConclusionsSARS-CoV-2 variant tracing highlights both, low infection dose transmissions suggestive of fomites as route of infection in the initial cluster and high and low infection dose transmissions in family clusters indicative of fomites and droplets as infection routes. This suggests (1) single viral particle infection can be sufficient to initiate SARS-CoV-2 infection and (2) household/family members are exposed to high virus loads and therefore have a high risk to acquire SARS-CoV-2.

ACS Style

Susanne Pfefferle; Thomas Guenther; Robin Kobbe; Manja Czech-Sioli; Dominic Nörz; René Santer; Jun Oh; Stefan Kluge; Lisa Oestereich; Kersten Peldschus; Daniela Indenbirken; Jiabin Huang; Adam Grundhoff; Martin Aepfelbacher; Johannes K. Knobloch; Marc Luetgehetmann; Nicole Fischer. Low and high infection dose transmissions of SARS-CoV-2 in the first COVID-19 clusters in Northern Germany. 2020, 1 .

AMA Style

Susanne Pfefferle, Thomas Guenther, Robin Kobbe, Manja Czech-Sioli, Dominic Nörz, René Santer, Jun Oh, Stefan Kluge, Lisa Oestereich, Kersten Peldschus, Daniela Indenbirken, Jiabin Huang, Adam Grundhoff, Martin Aepfelbacher, Johannes K. Knobloch, Marc Luetgehetmann, Nicole Fischer. Low and high infection dose transmissions of SARS-CoV-2 in the first COVID-19 clusters in Northern Germany. . 2020; ():1.

Chicago/Turabian Style

Susanne Pfefferle; Thomas Guenther; Robin Kobbe; Manja Czech-Sioli; Dominic Nörz; René Santer; Jun Oh; Stefan Kluge; Lisa Oestereich; Kersten Peldschus; Daniela Indenbirken; Jiabin Huang; Adam Grundhoff; Martin Aepfelbacher; Johannes K. Knobloch; Marc Luetgehetmann; Nicole Fischer. 2020. "Low and high infection dose transmissions of SARS-CoV-2 in the first COVID-19 clusters in Northern Germany." , no. : 1.

Preprint content
Published: 10 June 2020 in bioRxiv
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Human tuberculosis is caused by members of the Mycobacterium tuberculosis Complex (MTBC). The MTBC comprises several human-adapted lineages known as M. tuberculosis sensu stricto as well as two lineages (L5 and L6) traditionally referred to as M. africanum. Strains of L5 and L6 are largely limited to West Africa for reasons unknown, and little is known on their genomic diversity, phylogeography and evolution. Here, we analyzed the genomes of 365 L5 and 326 L6 strains, plus five related genomes that had not been classified into any of the known MTBC lineages, isolated from patients from 21 African countries.Our population genomic and phylogeographical analyses show that the unclassified genomes belonged to a new group that we propose to name MTBC Lineage 9 (L9). While the most likely ancestral distribution of L9 was predicted to be East Africa, the most likely ancestral distribution for both L5 and L6 was the Eastern part of West Africa. Moreover, we found important differences between L5 and L6 strains with respect to their phylogeographical substructure, genetic diversity and association with drug resistance. In conclusion, our study sheds new light onto the genomic diversity and evolutionary history of M. africanum, and highlights the need to consider the particularities of each MTBC lineage for understanding the ecology and epidemiology of tuberculosis in Africa and globally.

ACS Style

Mireia Coscolla; Daniela Brites; Fabrizio Menardo; Chloe Marie Loiseau; Sonia Borrell; Isaac Darko Otchere; Adwoa Asante-Poku; Prince Asare; Leonor Sanchez-Buso; Florian Gehre; C. N Dira Sanoussi; Martin Antonio; Affolabi Dissou; Paula Ruiz-Rodriguez; Janet Fyfe; Erik C. Böttger; Patrick Becket; Stefan Niemann; Abraham S. Alabi; Martin P. Grobusch; Robin Kobbe; Julian Parkhill; Christian Beisel; Lukas Fenner; Conor J. Meehan; Simon R Harris; Bouke C. De Jong; Dorothy Yeboah-Manu; Sebastien Gagneux; Mireia Coscolla Devis; Sonia Borrell Farnov. Phylogenomics of Mycobacterium africanum reveals a new lineage and a complex evolutionary history. bioRxiv 2020, 1 .

AMA Style

Mireia Coscolla, Daniela Brites, Fabrizio Menardo, Chloe Marie Loiseau, Sonia Borrell, Isaac Darko Otchere, Adwoa Asante-Poku, Prince Asare, Leonor Sanchez-Buso, Florian Gehre, C. N Dira Sanoussi, Martin Antonio, Affolabi Dissou, Paula Ruiz-Rodriguez, Janet Fyfe, Erik C. Böttger, Patrick Becket, Stefan Niemann, Abraham S. Alabi, Martin P. Grobusch, Robin Kobbe, Julian Parkhill, Christian Beisel, Lukas Fenner, Conor J. Meehan, Simon R Harris, Bouke C. De Jong, Dorothy Yeboah-Manu, Sebastien Gagneux, Mireia Coscolla Devis, Sonia Borrell Farnov. Phylogenomics of Mycobacterium africanum reveals a new lineage and a complex evolutionary history. bioRxiv. 2020; ():1.

Chicago/Turabian Style

Mireia Coscolla; Daniela Brites; Fabrizio Menardo; Chloe Marie Loiseau; Sonia Borrell; Isaac Darko Otchere; Adwoa Asante-Poku; Prince Asare; Leonor Sanchez-Buso; Florian Gehre; C. N Dira Sanoussi; Martin Antonio; Affolabi Dissou; Paula Ruiz-Rodriguez; Janet Fyfe; Erik C. Böttger; Patrick Becket; Stefan Niemann; Abraham S. Alabi; Martin P. Grobusch; Robin Kobbe; Julian Parkhill; Christian Beisel; Lukas Fenner; Conor J. Meehan; Simon R Harris; Bouke C. De Jong; Dorothy Yeboah-Manu; Sebastien Gagneux; Mireia Coscolla Devis; Sonia Borrell Farnov. 2020. "Phylogenomics of Mycobacterium africanum reveals a new lineage and a complex evolutionary history." bioRxiv , no. : 1.

Other
Published: 17 April 2020
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SARS-CoV-2 is the causative agent of COVID-19 and is a severe threat to global health. Patients infected with SARS-CoV-2 show a wide range of symptoms and disease severity, while limited data is available on its immunogenicity. Here, the kinetics of the development of SARS-CoV-2-specific antibody responses in relation to clinical features and dynamics of specific B-cell populations are reported. Immunophenotyping of B cells was performed by flow cytometry with longitudinally collected PBMCs. In parallel, serum samples were analyzed for the presence of SARS-CoV-2-specific IgA, IgG, and IgM antibodies using whole proteome peptide microarrays. Soon after disease onset in a mild case, we observed an increased frequency of plasmablasts concomitantly with a strong SARS-CoV-2-specific IgA response. In contrast, a case with more severe progression showed a delayed, but eventually very strong and broad SARS-CoV-2-specific IgA response. This case study shows that determining SARS-CoV-2-specific antibody epitopes can be valuable to monitor the specificity and magnitude of the early B-cell response, which could guide the development of vaccine candidates. Follow-up studies are required to evaluate whether the kinetics and strength of the SARS-CoV-2-specific IgA response could be potential prognostic markers of viral control.

ACS Style

Christine Dahlke; Jasmin Heidepriem; Robin Kobbe; Rene Santer; Till Koch; Anahita Fathi; My L. Ly; Stefan Schmiedel; Peter H. Seeberger; ID-UKE COVID-19 study group; Marylyn M. Addo; Felix F. Loeffler. Distinct early IgA profile may determine severity of COVID-19 symptoms: an immunological case series. 2020, 1 .

AMA Style

Christine Dahlke, Jasmin Heidepriem, Robin Kobbe, Rene Santer, Till Koch, Anahita Fathi, My L. Ly, Stefan Schmiedel, Peter H. Seeberger, ID-UKE COVID-19 study group, Marylyn M. Addo, Felix F. Loeffler. Distinct early IgA profile may determine severity of COVID-19 symptoms: an immunological case series. . 2020; ():1.

Chicago/Turabian Style

Christine Dahlke; Jasmin Heidepriem; Robin Kobbe; Rene Santer; Till Koch; Anahita Fathi; My L. Ly; Stefan Schmiedel; Peter H. Seeberger; ID-UKE COVID-19 study group; Marylyn M. Addo; Felix F. Loeffler. 2020. "Distinct early IgA profile may determine severity of COVID-19 symptoms: an immunological case series." , no. : 1.

Reference work
Published: 25 August 2019 in Psychiatrie und Psychotherapie des Kindes- und Jugendalters
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Schon immer haben Parasiten den Menschen begleitet und sich dabei gegenseitig beeinflusst und somit die Evolution geprägt. Parasitäre Erkrankungen kommen zwar in allen Klimazonen vor, jedoch zählen die meisten und relevantesten Parasitosen heute zu den oft vernachlässigten Tropenerkrankungen, die auch aufgrund von Armut und damit verbundenen hygienischen Bedingungen meist in benachteiligten Bevölkerungsgruppen anzutreffen sind. Neben Plasmodien, den Erregern der Malaria, sind weitere Parasiten speziell bei Kindern und Jugendlichen von besonderer Bedeutung. Durch vermehrte Reiseaktivität von Kindern, Verwandtenbesuch von Migranten, sowie Zustrom von Geflüchteten in einer globalen Gesellschaft müssen Kinderärzte heute mit den klinischen Symptomen nichtendemischer Infektionskrankheiten vertraut sein. Das Kapitel gibt einen Überblick über die wichtigsten Erreger, die Pathogenese von Krankheitsbildern bei Kindern und Jugendlichen, Diagnostik und Therapie und soll auch einen Einblick in Bekämpfungsstrategien und Forschungsansätze liefern.

ACS Style

Robin Kobbe. Protozoen und Helminthen bei Kindern und Jugendlichen. Psychiatrie und Psychotherapie des Kindes- und Jugendalters 2019, 1 -32.

AMA Style

Robin Kobbe. Protozoen und Helminthen bei Kindern und Jugendlichen. Psychiatrie und Psychotherapie des Kindes- und Jugendalters. 2019; ():1-32.

Chicago/Turabian Style

Robin Kobbe. 2019. "Protozoen und Helminthen bei Kindern und Jugendlichen." Psychiatrie und Psychotherapie des Kindes- und Jugendalters , no. : 1-32.

Hiv reports
Published: 01 July 2019 in Pediatric Infectious Disease Journal
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Using retrospectively collected data from 383 infants born to HIV-1-infected mothers receiving antiretroviral therapy, we compared transmission rates and hematologic toxicity between infants receiving 2-week (short course) versus longer duration zidovudine postexposure prophylaxis. Short course resulted in lower hematologic toxicity without evidence of increased vertical transmission risk.

ACS Style

Thi Thanh Truc Nguyen; Robin Kobbe; Ulf Schulze-Sturm; Martin Blohm; Bettina Hollwitz; Sandra Hertling; Christina Becker; Prasad Thomas Oommen; Hans-Jürgen Laws; Franca Martignoni; Björn-Erik Ole Jensen; Karen Olah; Susanne Schmidtke; Benno Kreuels; Malte Kohns Vasconcelos; Jennifer Neubert. Reducing Hematologic Toxicity With Short Course Postexposure Prophylaxis With Zidovudine for HIV-1 Exposed Infants With Low Transmission Risk. Pediatric Infectious Disease Journal 2019, 38, 727 -730.

AMA Style

Thi Thanh Truc Nguyen, Robin Kobbe, Ulf Schulze-Sturm, Martin Blohm, Bettina Hollwitz, Sandra Hertling, Christina Becker, Prasad Thomas Oommen, Hans-Jürgen Laws, Franca Martignoni, Björn-Erik Ole Jensen, Karen Olah, Susanne Schmidtke, Benno Kreuels, Malte Kohns Vasconcelos, Jennifer Neubert. Reducing Hematologic Toxicity With Short Course Postexposure Prophylaxis With Zidovudine for HIV-1 Exposed Infants With Low Transmission Risk. Pediatric Infectious Disease Journal. 2019; 38 (7):727-730.

Chicago/Turabian Style

Thi Thanh Truc Nguyen; Robin Kobbe; Ulf Schulze-Sturm; Martin Blohm; Bettina Hollwitz; Sandra Hertling; Christina Becker; Prasad Thomas Oommen; Hans-Jürgen Laws; Franca Martignoni; Björn-Erik Ole Jensen; Karen Olah; Susanne Schmidtke; Benno Kreuels; Malte Kohns Vasconcelos; Jennifer Neubert. 2019. "Reducing Hematologic Toxicity With Short Course Postexposure Prophylaxis With Zidovudine for HIV-1 Exposed Infants With Low Transmission Risk." Pediatric Infectious Disease Journal 38, no. 7: 727-730.

Case reports
Published: 01 May 2017 in Transplantation
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Persistently elevated eosinophil granulocytes in the peripheral blood in children is challenging because of a complex diagnosis especially after solid organ transplantation and can lead to difficulties in finding an underlying causative factor. We report a 12-year-old boy who developed severe hypereosinophilia 11 years after liver transplantation due to biliary atresia. Accompanying symptoms were recurrent fever, fatigue, elevated liver enzymes, abdominal pain, and significant weight loss. After exclusion of secondary causes of eosinophilia, an idiopathic hypereosinophilic syndrome (I-HES) was diagnosed. Treatment with prednisolone resulted in an immediate response with rapid reduction of eosinophils, normalization of liver enzymes, and amelioration of any clinical symptoms. A hypereosinophilic syndrome in patients after liver transplantation is rare, and a broad differential diagnosis has to be considered. Prednisolone may lead to a prompt amelioration of eosinophilia and associated symptoms.

ACS Style

Wiebke Aulbert; Robin Kobbe; Christian Breuer; Andrea Briem-Richter; Hansjörg Schäfer; Florian Brinkert; Anne Dettmar; Markus Josef Kemper; Enke Grabhorn. Hypereosinophilic Syndrome After Liver Transplantation. Transplantation 2017, 101, e166 -e169.

AMA Style

Wiebke Aulbert, Robin Kobbe, Christian Breuer, Andrea Briem-Richter, Hansjörg Schäfer, Florian Brinkert, Anne Dettmar, Markus Josef Kemper, Enke Grabhorn. Hypereosinophilic Syndrome After Liver Transplantation. Transplantation. 2017; 101 (5):e166-e169.

Chicago/Turabian Style

Wiebke Aulbert; Robin Kobbe; Christian Breuer; Andrea Briem-Richter; Hansjörg Schäfer; Florian Brinkert; Anne Dettmar; Markus Josef Kemper; Enke Grabhorn. 2017. "Hypereosinophilic Syndrome After Liver Transplantation." Transplantation 101, no. 5: e166-e169.

Case report
Published: 20 March 2017 in BMC Nephrology
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Influenza A infections have been described to cause secondary hemolytic uremic syndrome and to trigger atypical hemolytic uremic syndrome (aHUS) in individuals with an underlying genetic complement dysregulation. To date, influenza B has not been reported to trigger aHUS. A 6-month-old boy presented with hemolytic uremic syndrome triggered by influenza B infection. Initially the child recovered spontaneously. When he relapsed Eculizumab treatment was initiated, resulting in complete and sustained remission. A pathogenic mutation in membrane cofactor protein (MCP) was detected. Influenza B is a trigger for aHUS and might be underreported as such. Influenza vaccination may protect patients at risk.

ACS Style

Robin Kobbe; Raphael Schild; Martin Christner; Jun Oh; Sebastian Loos; Markus J. Kemper. Case report - atypical hemolytic uremic syndrome triggered by influenza B. BMC Nephrology 2017, 18, 1 -4.

AMA Style

Robin Kobbe, Raphael Schild, Martin Christner, Jun Oh, Sebastian Loos, Markus J. Kemper. Case report - atypical hemolytic uremic syndrome triggered by influenza B. BMC Nephrology. 2017; 18 (1):1-4.

Chicago/Turabian Style

Robin Kobbe; Raphael Schild; Martin Christner; Jun Oh; Sebastian Loos; Markus J. Kemper. 2017. "Case report - atypical hemolytic uremic syndrome triggered by influenza B." BMC Nephrology 18, no. 1: 1-4.

Journal article
Published: 01 December 2015 in Vaccine
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During this year's 33rd annual meeting in Leipzig, Germany, the European Society of Paediatric Infectious Diseases (ESPID) jointly together with the European Scientific Working group on Influenza (ESWI), organized a staged debate on the motion of universal annual immunization of children against influenza as a cost-effective health intervention in Europe. Six invited speakers, all experts in the field of influenza vaccination, who were not necessary confident with their given position of pro or contra, battled each other with short oral presentations to convince the audience to vote for or against the motion.

ACS Style

Robin Kobbe. The ESPID/ESWI Joint Symposium—A strong vote for universal influenza vaccination in children in Europe. Vaccine 2015, 33, 6967 -6969.

AMA Style

Robin Kobbe. The ESPID/ESWI Joint Symposium—A strong vote for universal influenza vaccination in children in Europe. Vaccine. 2015; 33 (49):6967-6969.

Chicago/Turabian Style

Robin Kobbe. 2015. "The ESPID/ESWI Joint Symposium—A strong vote for universal influenza vaccination in children in Europe." Vaccine 33, no. 49: 6967-6969.

Journal article
Published: 01 January 2014 in International Journal of Health Geographics
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Malaria is a mosquito-borne parasitic disease that causes severe mortality and morbidity, particularly in Sub-Saharan Africa. As the vectors predominantly bite between dusk and dawn, risk of infection is determined by the abundance of P. falciparum infected mosquitoes in the surroundings of the households. Remote sensing is commonly employed to detect associations between land use/land cover (LULC) and mosquito-borne diseases. Due to challenges in LULC identification and the fact that LULC merely functions as a proxy for mosquito abundance, assuming spatially homogenous relationships may lead to overgeneralized conclusions. Data on incidence of P. falciparum parasitaemia were recorded by active and passive follow-up over two years. Nine LULC types were identified through remote sensing and ground-truthing. Spatial associations of LULC and P. falciparum parasitaemia rate were described in a semi-parametric geographically weighted Poisson regression model. Complete data were available for 878 individuals, with an annual P. falciparum rate of 3.2 infections per person-year at risk. The influences of built-up areas (median incidence rate ratio (IRR): 0.94, IQR: 0.46), forest (median IRR: 0.9, IQR: 0.51), swampy areas (median IRR: 1.15, IQR: 0.88), as well as banana (median IRR: 1.02, IQR: 0.25), cacao (median IRR: 1.33, IQR: 0.97) and orange plantations (median IRR: 1.11, IQR: 0.68) on P. falciparum rate show strong spatial variations within the study area. Incorporating spatial variability of LULC variables increased model performance compared to the spatially homogenous model. The observed spatial variability of LULC influence in parasitaemia would have been masked by traditional Poisson regression analysis assuming a spatially constant influence of all variables. We conclude that the spatially varying effects of LULC on P. falciparum parasitaemia may in fact be associated with co-factors not captured by remote sensing, and suggest that future studies assess small-scale spatial variation of vegetation to circumvent generalised assumptions on ecological associations that may in fact be artificial.

ACS Style

Lutz Ehlkes; Anne Caroline Krefis; Benno Kreuels; Ralf Krumkamp; Ohene Adjei; Matilda Ayim-Akonor; Robin Kobbe; Andreas Hahn; Christof Vinnemeier; Wibke Loag; Udo Schickhoff; Jürgen May. Geographically weighted regression of land cover determinants of Plasmodium falciparum transmission in the Ashanti Region of Ghana. International Journal of Health Geographics 2014, 13, 35 .

AMA Style

Lutz Ehlkes, Anne Caroline Krefis, Benno Kreuels, Ralf Krumkamp, Ohene Adjei, Matilda Ayim-Akonor, Robin Kobbe, Andreas Hahn, Christof Vinnemeier, Wibke Loag, Udo Schickhoff, Jürgen May. Geographically weighted regression of land cover determinants of Plasmodium falciparum transmission in the Ashanti Region of Ghana. International Journal of Health Geographics. 2014; 13 (1):35.

Chicago/Turabian Style

Lutz Ehlkes; Anne Caroline Krefis; Benno Kreuels; Ralf Krumkamp; Ohene Adjei; Matilda Ayim-Akonor; Robin Kobbe; Andreas Hahn; Christof Vinnemeier; Wibke Loag; Udo Schickhoff; Jürgen May. 2014. "Geographically weighted regression of land cover determinants of Plasmodium falciparum transmission in the Ashanti Region of Ghana." International Journal of Health Geographics 13, no. 1: 35.