Karen Keane

Dr. Karen Keane

orcid

Research Focus & Metrics

Academic Career Length

12Years (2015-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 June 2016 in The American Journal of Clinical Nutrition
Verified
Journal Article
Closed access
PDF file
KKKaren Keane
Karen Keane
TGTrevor W George
Trevor W George
CCCostas L Constantinou
Costas L Constantinou
MBMeghan A Brown
Meghan A Brown
TCTom Clifford
Tom Clifford
Glyn HowatsonGlyn Howatson
Glyn Howatson
Background: Tart cherries contain numerous polyphenolic compounds that could potentially improve endothelial function and reduce cardiovascular diseas

11 July 2015 in European Journal of Nutrition
Verified
Journal Article
Closed access
PDF file
KKKaren Keane
Karen Keane
PBPhillip G. Bell
Phillip G. Bell
John LodgeJohn Lodge
John Lodge
CCCostas L. Constantinou
Costas L. Constantinou
SJSarah E. Jenkinson
Sarah E. Jenkinson
Glyn HowatsonGlyn Howatson
Glyn Howatson

1 March 2017 in Applied Physiology, Nutrition, and Metabolism
Verified
Journal Article
Closed access
TCTom Clifford
Tom Clifford
DADean Allerton
Dean Allerton
MBMeghan A. Brown
Meghan A. Brown
LHLiam Harper
Liam Harper
SHSteven Horsburgh
Steven Horsburgh
Glyn HowatsonGlyn Howatson
Glyn Howatson
This study examined whether beetroot juice (BTJ) would attenuate inflammation and muscle damage following a marathon. Using a double blind, independent group design, 34 runners (each having completed ca. ∼16 previous marathons) consumed either BTJ or an isocaloric placebo (PLA) for 3 days following a marathon. Maximal isometric voluntary contractions (MIVC), countermovement jumps (CMJ), muscle soreness, serum cytokines, leucocytosis, creatine kinase (CK), high sensitivity C-reactive protein (hs-CRP), and aspartate aminotransferase (AST) were measured pre, post, and 2 days after the marathon. CMJ and MIVC were reduced after the marathon (P < 0.05), but no group differences were observed (P > 0.05). Muscle soreness was increased in the day after the marathon (BTJ; 45 ± 48 vs. PLA; 46 ± 39 mm) and had returned to baseline by day 2, irrespective of supplementation (P = 0.694). Cytokines (interleukin-6; IL-6, interleukin-8, tumour necrosis factor-α) were increased immediately post-marathon but apart from IL-6 had returned to baseline values by day 1 post. No interaction effects were evident for IL-6 (P = 0.213). Leucocytes increased 1.7-fold after the race and remained elevated 2 days post, irrespective of supplement (P < 0.0001). CK peaked at 1 day post marathon (BTJ: 965 ± 967, and PLA: 1141 ± 979 IU·L−1) and like AST and hs-CRP, was still elevated 2 days after the marathon (P < 0.05); however, no group differences were present for these variables. Beetroot juice did not attenuate inflammation or reduce muscle damage following a marathon, possibly because most of these indices were not markedly different from baseline values in the days after the marathon.

12 February 2016 in European Journal of Nutrition
Verified
Journal Article
Open access
PDF file
TCTom Clifford
Tom Clifford
CCCostas M. Constantinou
Costas M. Constantinou
KKKaren Keane
Karen Keane
DWDaniel West
Daniel West
Glyn HowatsonGlyn Howatson
Glyn Howatson
ESEmma J. Stevenson
Emma J. Stevenson
To evaluate the plasma bioavailability of betanin and nitric oxide (NOx) after consuming beetroot juice (BTJ) and whole beetroot (BF). BTJ and BF were also analysed for antioxidant capacity, polyphenol content (TPC) and betalain content.

5 January 2017 in Acta Physiologica
Verified
Journal Article
Closed access
PDF file
Stuart GoodallStuart Goodall
Stuart Goodall
KTK. Thomas
K. Thomas
MBM. Barwood
M. Barwood
KKKaren Keane
Karen Keane
JGJ. T. Gonzalez
J. T. Gonzalez
Glyn HowatsonGlyn Howatson
Glyn Howatson

22 March 2018 in Scandinavian Journal of Medicine & Science in Sports
Verified
Journal Article
Open access
PDF file
KKKaren Keane
Karen Keane
SBStephen Bailey
Stephen Bailey
AVA. Vanhatalo
A. Vanhatalo
AJA. M. Jones
A. M. Jones
Glyn HowatsonGlyn Howatson
Glyn Howatson
The purpose of this study was to investigate the effects of Montmorency tart cherry juice (MC) on nitric oxide (NO) biomarkers, vascular function, and exercise performance. In a randomized, double‐blind, placebo (PLA)‐controlled, crossover study, 10 trained cyclists (mean ± SD; O2peak 59.0 ± 7.0 mL/kg/min) acutely ingested 30 mL of either MC or PLA following dietary restrictions of polyphenol‐rich compounds and completed 6‐minutes moderate‐ and severe‐intensity cycling bouts 1.5 hour post‐ingestion on 2 occasions for each experimental condition. The severe‐intensity cycling test was continued to exhaustion on 1 occasion and immediately followed by a 60‐seconds all‐out sprint on the other occasion. Blood pressure, pulse wave measures, tissue oxygenation index, and plasma nitrite concentration were assessed pre‐ and 1.5 hour post‐ingestion. Time to exhaustion was not different between conditions (P > .05), but peak power over the first 20 seconds (363 ± 42 vs 330 ± 26 W) and total work completed during the 60‐seconds all‐out sprint (21 ± 3 vs 19 ± 3 kJ) were 10% higher in the MC trial compared to the PLA trial (P < .05). Systolic blood pressure was 5 ± 2 mm Hg lower 1.5 hour post‐MC supplementation compared to PLA supplementation (P < .05). There were no differences in pulse wave measures, plasma nitrite concentration, or tissue oxygenation between the MC and PLA trials (P > .05). These results suggest that acute supplementation with MC can lower blood pressure and improve some aspects of exercise performance, specifically end‐sprint performance, in trained cyclists.