Galina Koltsova

Dr. Galina Koltsova

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Academic Career Length

12Years (2015-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 July 2017 in Journal of General Virology
Verified
Journal Article
Closed access
JPJacques Le Pendu
Jacques Le Pendu
JAJoana Abrantes
Joana Abrantes
SBStéphane Bertagnoli
Stéphane Bertagnoli
JGJean-Sébastien Guitton
Jean-Sébastien Guitton
GGGhislaine Le Gall-Reculé
Ghislaine Le Gall-Reculé
Pedro EstevesPedro Esteves
Pedro Esteves
Lagoviruses belong to the Caliciviridae family. They were first recognized as highly pathogenic viruses of the European rabbit (Oryctolagus cuniculus) and European brown hare (Lepus europaeus) that emerged in the 1970–1980s, namely, rabbit haemorrhagic disease virus (RHDV) and European brown hare syndrome virus (EBHSV), according to the host species from which they had been first detected. However, the diversity of lagoviruses has recently expanded to include new related viruses with varying pathogenicity, geographic distribution and host ranges. Together with the frequent recombination observed amongst circulating viruses, there is a clear need to establish precise guidelines for classifying and naming lagovirus strains. Therefore, here we propose a new nomenclature based on phylogenetic relationships. In this new nomenclature, a single species of lagovirus would be recognized and called Lagovirus europaeus. The species would be divided into two genogroups that correspond to RHDV- and EBHSV-related viruses, respectively. Genogroups could be subdivided into genotypes, which could themselves be subdivided into phylogenetically well-supported variants. Based on available sequences, pairwise distance cutoffs have been defined, but with the accumulation of new sequences these cutoffs may need to be revised. We propose that an international working group could coordinate the nomenclature of lagoviruses and any proposals for revision.
1 February 2015 in Emerging Infectious Diseases
Verified
Journal Article
Open access
AMAlex Malogolovkin
Alex Malogolovkin
GKGalina Koltsova
Galina Koltsova
ITIlya Titov
Ilya Titov
ASAlexey Sereda
Alexey Sereda
AGAndrey Gogin
Andrey Gogin
Denis KolbasovDenis Kolbasov
Denis Kolbasov
African swine fever virus (ASFV) causes highly lethal hemorrhagic disease among pigs, and ASFV’s extreme antigenic diversity hinders vaccine development. We show that p72 ASFV phylogenetic analysis does not accurately define ASFV hemadsorption inhibition assay serogroups. Thus, conventional ASFV genotyping cannot discriminate between viruses of different virulence or predict efficacy of a specific ASFV vaccine.
1 April 2015 in Journal of General Virology
Verified
Journal Article
Closed access
AMAlex Malogolovkin
Alex Malogolovkin
GKGalina Koltsova
Galina Koltsova
ETE. R. Tulman
E. R. Tulman
GDG. Delhon
G. Delhon
DDD. G. Diel
D. G. Diel
DRD. L. Rock
D. L. Rock
African swine fever (ASF) is an emerging disease threat for the swine industry worldwide. No ASF vaccine is available and progress is hindered by lack of knowledge concerning the extent of ASF virus (ASFV) strain diversity and the viral antigens responsible for protection in the pig. Available data from vaccination/challenge experiments in pigs indicate ASF protective immunity is haemadsorption inhibition (HAI) serotype-specific. A better understanding of ASFV HAI serological groups and their diversity in nature, as well as improved methods to serotype ASFV isolates, is needed. Here, we demonstrated that the genetic locus encoding ASFV CD2v and C-type lectin proteins mediates HAI serological specificity and that CD2v/C-type lectin genotyping provides a simple method to group ASFVs by serotype, thus facilitating study of ASFV strain diversity in nature, and providing information necessary for eventual vaccine design, development and efficacious use.
1 July 2016 in Journal of General Virology
Verified
Journal Article
Open access
GKGalina Koltsova
Galina Koltsova
AMAlex Malogolovkin
Alex Malogolovkin
ETE. R. Tulman
E. R. Tulman
LZL. Zsak
L. Zsak
GDG. Delhon
G. Delhon
DRD. L. Rock
D. L. Rock
African swine fever (ASF) is an emerging disease threat for the swine industry worldwide. No ASF vaccine is available and progress is hindered by lack of knowledge concerning the extent of ASFV strain diversity and the viral antigens conferring type-specific protective immunity in pigs. Available data from vaccination/challenge experiments in pigs indicate that ASF protective immunity may be haemadsorption inhibition (HAI) serotype-specific. Recently, we have shown that two ASFV proteins, CD2v (EP402R) and C-type lectin (EP153R), are necessary and sufficient for mediating HAI serological specificity (Malogolovkin et al., 2015).. Here, using ASFV inter-serotypic chimeric viruses and vaccination/challenge experiments in pigs, we demonstrate that serotype-specific CD2v and/or C-type lectin proteins are important for protection against homologous ASFV infection. Thus, these viral proteins represent significant protective antigens for ASFV that should be targeted in future vaccine design and development. Additionally, these data support the concept of HAI serotype-specific protective immunity
28 June 2021 in Viruses
Verified
Journal Article
Open access
PDF file
GKGalina Koltsova
Galina Koltsova
AKAndrey Koltsov
Andrey Koltsov
СКСергей Крутько
Сергей Крутько
NKNatalia Kholod
Natalia Kholod
ETEdan Tulman
Edan Tulman
Denis KolbasovDenis Kolbasov
Denis Kolbasov
African swine fever (ASF) is an emerging disease threat to the swine industry worldwide. There is no vaccine against ASF, and progress is hindered by a lack of knowledge concerning the extent of ASFV strain diversity and the viral antigens conferring type-specific protective immunity in pigs. We have previously demonstrated that homologous ASFV serotype-specific proteins CD2v (EP402R) and/or C-type lectin are required for protection against challenge with the virulent ASFV strain Congo (Genotype I, Serogroup 2), and we have identified T-cell epitopes on CD2v which may be associated with serotype-specific protection. Here, using a cell-culture adapted derivative of the ASFV strain Congo (Congo-a) with specific deletion of the EP402R gene (ΔCongoCD2v) in swine vaccination/challenge experiments, we demonstrated that deletion of the EP402R gene results in the failure of ΔCongoCD2v to induce protection against challenge with the virulent strain Congo (Congo-v). While ΔCongoCD2v growth kinetics in COS-1 cells and primary swine macrophage culture were almost identical to parental Congo-a, replication of ΔCongoCD2v in vivo was significantly reduced compared with parental Congo-a. Our data support the idea that the CD2v protein is important for the ability of homologous live-attenuated vaccines to induce protective immunity against the ASFV strain Congo challenge in vivo.
10 July 2017 in Archives of Virology
Verified
Journal Article
Closed access
PDF file
ITIlya Titov
Ilya Titov
GKGalina Koltsova
Galina Koltsova
YMYuriy Morgunov
Yuriy Morgunov
SMSergey Morgunov
Sergey Morgunov
AKAndrey Koltsov
Andrey Koltsov
Denis KolbasovDenis Kolbasov
Denis Kolbasov