Baena-Raya, A, Jiménez-Reyes, P, Romea, ES, Soriano-Maldonado, A, and Rodríguez-Pérez, MA. Gender-specific association of the sprint mechanical properties with change of direction performance in basketball. J Strength Cond Res 36(10): 2868–2874, 2022—We evaluated the gender-specific associations between the mechanical variables derived from the horizontal force-velocity (FV) profile (i.e., theoretical maximal force [F 0], velocity [V 0], maximal power output [P max], peak ratio of the effective horizontal component [RF
peak
], and the force application technique index [D
RF
]) and the change of direction (COD) performance for basketball players. Seventy-one players (23 women and 48 men) were assessed for the horizontal FV profile and COD using the modified 505 and V-cut tests. The FV profile parameters were significantly higher for the men than those for the women. The F
0
, RF
peak
, and P max were strongly associated with performance in the 505 test (women r range = −0.72 to −0.82; men: r range = −0.67 to −0.75; p < 0.001) and the V-cut test (women r range = −0.68 to −0.76; men r range = −0.45 to −0.50; p < 0.001), as well as with a lower COD deficit (women r range = 0.58 to 0.75 (p < 0.01); men r range = 0.49 to 0.54; all p < 0.001). For the women, a 1 N·kg−1 increase of the F
0
was associated with −0.20 seconds and −0.56 seconds in the 505 and V-cut tests, respectively, and 0.16 seconds for the COD deficit. In the men, it was associated with −0.13 seconds and −0.37 seconds in the 505 and V-cut tests, respectively, and 0.10 seconds for the COD deficit. F
0
, RF
peak
, and P max are the most determinant sprint mechanical properties to successfully COD and reduce the COD deficit. The horizontal FV profile assessment is recommended for diagnosing and prescribing a training program for basketball players.