Pin Ju Chueh

Prof. Dr. Pin Ju Chueh

Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan
orcid

Research Focus & Metrics

Academic Career Length

32Years (1995-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 July 2008 in Toxicology Letters
Verified
Journal Article
Closed access
YHYi-Hong Hsin
Yi-Hong Hsin
CCChun-Feng Chen
Chun-Feng Chen
SHShing Huang
Shing Huang
TSTung-Sheng Shih
Tung-Sheng Shih
PLPing-Shan Lai
Ping-Shan Lai
Pin Ju ChuehPin Ju Chueh
Pin Ju Chueh

14 March 1995 in Proceedings of the National Academy of Sciences
Verified
Journal Article
Closed access
DMD J Morré
D J Morré
Pin Ju ChuehPin Ju Chueh
Pin Ju Chueh
DMD M Morré
D M Morré
A hormone- and growth factor-stimulated NADH oxidase of the mammalian plasma membrane, constitutively activated in transformed cells, was inhibited preferentially in HeLa, ovarian carcinoma, mammary adenocarcinoma, and HL-60 cells, all of human origin, by the naturally occurring quinone analog capsaicin (8-methyl-N-vanillyl-6-noneamide), compared with plasma membranes from human mammary epithelial, rat liver, normal rat kidney cells, or HL-60 cells induced to differentiate with dimethyl sulfoxide. With cells in culture, capsaicin preferentially inhibited growth of HeLa, ovarian carcinoma, mammary adenocarcinoma, and HL-60 cells but was largely without effect on the mammary epithelial cells, rat kidney cells, or HL-60 cells induced to differentiate with dimethyl sulfoxide. Inhibited cells became smaller and cell death was accompanied by a condensed and fragmented appearance of the nuclear DNA, as revealed by fluorescence microscopy with 4',6-diamidino-2-phenylindole, suggestive of apoptosis. The findings correlate capsaicin inhibition of cell surface NADH oxidase activity and inhibition of growth that correlate with capsaicin-induced apoptosis.

1 December 2009 in Toxicology and Applied Pharmacology
Verified
Journal Article
Closed access
SHShing Huang
Shing Huang
Pin Ju ChuehPin Ju Chueh
Pin Ju Chueh
YLYun-Wei Lin
Yun-Wei Lin
TSTung-Sheng Shih
Tung-Sheng Shih
SCShow-Mei Chuang
Show-Mei Chuang

1 January 2014 in Journal of Hazardous Materials
Verified
Journal Article
Closed access
Pin Ju ChuehPin Ju Chueh
Pin Ju Chueh
RLRuei-Yue Liang
Ruei-Yue Liang
YLYi-Hui Lee
Yi-Hui Lee
ZZZih-Ming Zeng
Zih-Ming Zeng
SCShow-Mei Chuang
Show-Mei Chuang

1 July 2010 in Free Radical Biology and Medicine
Verified
Journal Article
Closed access
YKYu-Feng Kuo
Yu-Feng Kuo
YSYing-Zhen Su
Ying-Zhen Su
YTYen-Hsueh Tseng
Yen-Hsueh Tseng
SWSheng-Yang Wang
Sheng-Yang Wang
HWHsi-Ming Wang
Hsi-Ming Wang
Pin Ju ChuehPin Ju Chueh
Pin Ju Chueh

1 October 2013 in Biochimica et Biophysica Acta (BBA) - General Subjects
Verified
Journal Article
Closed access
SCShow-Mei Chuang
Show-Mei Chuang
YLYi-Hui Lee
Yi-Hui Lee
RLRuei-Yue Liang
Ruei-Yue Liang
GRGwo-Dong Roam
Gwo-Dong Roam
ZZZih-Ming Zeng
Zih-Ming Zeng
Pin Ju ChuehPin Ju Chueh
Pin Ju Chueh