Recently, the automatic detection of decayed blueberries is still a challenge in food industry. Early decay of blueberries happens on surface peel, which may adopt the feasibility of hyperspectral imaging mode to detect decayed region of blueberries. An improved deep residual 3D convolutional neural network (3D-CNN) framework is proposed for hyperspectral images classification so as to realize fast training, classification, and parameter optimization. Rich spectral and spatial features can be rapidly extracted from samples of complete hyperspectral images using our proposed network. This combines the tree structured Parzen estimator (TPE) adaptively and selects the super parameters to optimize the network performance. In addition, aiming at the problem of few samples, this paper proposes a novel strategy to enhance the hyperspectral image sample data, which can improve the training effect. Experimental results on the standard hyperspectral blueberry datasets show that the proposed framework improves the classification accuracy compared with AlexNet and GoogleNet. In addition, our proposed network reduces the number of parameters by half and the training time by about 10%.

Breast cancer is estimated to be the leading cancer type among new cases in American women. Core biopsy data have shown a close association between breast hyperplasia and breast cancer. The early diagnosis and treatment of breast hyperplasia are extremely important to prevent breast cancer. The Mongolian medicine RuXian-I is a traditional drug that has achieved a high level of efficacy and a low incidence of side effects in its clinical use. However, for detecting the efficacy of RuXian-I, a rapid and accurate evaluation method based on metabolomic data is still lacking. Therefore, we proposed a framework, named the metabolomics deep belief network (MDBN), to analyze breast hyperplasia metabolomic data. We obtained 168 samples of metabolomic data from an animal model experiment of RuXian-I, which were averaged from control groups, treatment groups, and model groups. In the process of training, unlabelled data were used to pretrain the Deep Belief Networks models, and then labelled data were used to complete fine-tuning based on a limited-memory Broyden Fletcher Goldfarb Shanno (L-BFGS) algorithm. To prevent overfitting, a dropout method was added to the pretraining and fine-tuning procedures. The experimental results showed that the proposed model is superior to other classical classification methods that are based on positive and negative spectra data. Further, the proposed model can be used as an extension of the classification method for metabolomic data. For the high accuracy of classification of the three groups, the model indicates obvious differences and boundaries between the three groups. It can be inferred that the animal model of RuXian-I is well established, which can lay a foundation for subsequent related experiments. This also shows that metabolomic data can be used as a means to verify the effectiveness of RuXian-I in the treatment of breast hyperplasia.