Mrs. Georgia-Myrto Prifti
School of Health Sciences, Department of Pharmacy, Division of Pharmaceutical Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771, Athens, Greece
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Academic Career Length
6Years (2021-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
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Journal Article
Georgia-Myrto Prifti
Dimitrios Moianos
Erofili GiannakopoulouVPVasiliki Pardali
Vasiliki Pardali
John E. Tavis
Grigoris ZoidisHepatitis B virus infection affects over 250 million chronic carriers, causing more than 800,000 deaths annually, although a safe and effective vaccine is available. Currently used antiviral agents, pegylated interferon and nucleos(t)ide analogues, have major drawbacks and fail to completely eradicate the virus from infected cells. Thus, achieving a “functional cure” of the infection remains a real challenge. Recent findings concerning the viral replication cycle have led to development of novel therapeutic approaches including viral entry inhibitors, epigenetic control of cccDNA, immune modulators, RNA interference techniques, ribonuclease H inhibitors, and capsid assembly modulators. Promising preclinical results have been obtained, and the leading molecules under development have entered clinical evaluation. This review summarizes the key steps of the HBV life cycle, examines the currently approved anti-HBV drugs, and analyzes novel HBV treatment regimens.
Journal Article
Dimitrios MoianosGeorgia-Myrto Prifti
Maria MakriGrigoris ZoidisMetalloenzymes are central to the regulation of a wide range of essential viral and parasitic functions, including protein degradation, nucleic acid modification, and many others. Given the impact of infectious diseases on human health, inhibiting metalloenzymes offers an attractive approach to disease therapy. Metal-chelating agents have been expansively studied as antivirals and antiparasitics, resulting in important classes of metal-dependent enzyme inhibitors. This review provides the recent advances in targeting the metalloenzymes of viruses and parasites that impose a significant burden on global public health, including influenza A and B, hepatitis B and C, and human immunodeficiency viruses as well as Trypanosoma brucei and Trypanosoma cruzi.
About Me
Undergraduate student at the Faculty of Pharmacy of the National and Kapodistrian University of Athens (started 2016). I have already completed the total of 46 mandatory courses, 8 laboratory-based practical courses, 14 elective courses, a one-year thesis (30 ECTS). By July of 2021, I will complete the 5-year curriculum (300 ECTS- equivalent to Masters) and finally a practical internship in both a community and a hospital pharmacy. I am currently working on my thesis in the Department of Pharmaceutical Chemistry, which is entitled “Therapeutic Approaches for the Treatment of Hepatitis B”, under the supervision of prof. Grigoris Zoidis. The object that highly interests me is Medicinal Chemistry; organic synthesis, lead optimization, drug design, design novel active compounds, spectroscopical analysis and structure-activity relationships. I am planning to extend my knowledge and expertise in the field of Medicinal Chemistry by attending a postgraduate program by the time I finish my undergraduate studies.