Ongoing research in the dental field has begun to focus on the use of injectable platelet-rich fibrin (I-PRF) as a regenerative tool with the potential to prompt tissue regeneration. In this regard, this systematic scoping review aimed to collect, map, and appraise the in vitro and in vivo studies regarding the role of I-PRF in or soft and hard tissue regeneration in relation to oral and maxillofacial structures. A systematic electronic search of Medline, Scopus, Web of Science, and Embase databases was performed from 2000 to December 2021 using a combination of keywords. All in vitro and in vivo studies, written in English and concerning the potential role of I-PRF in regenerative dentistry were considered. In total, 18 in vitro studies, 5 animal studies, 6 case reports, and 31 clinical studies have evaluated the effect of I-PRF on oral and maxillofacial soft and hard tissue regeneration. The investigated studies verified the anti-inflammatory, anti-microbial efficacy and the positive effects of I-PRF application for wound, periodontal, bone, cartilage, and pulp regeneration, as well as acceleration in tooth movement during orthodontic treatment. Current literature approves the feasibility of I-PRF application as a promising regenerative adjunct to dental procedures.

Introduction: Dentinal hypersensitivity (DH) is an acute intensive tooth pain which can lead to dental annoyances during eating and drinking. Stimulating exposed dentinal tubules by either kind of thermal, tactile, chemical and/or osmotic stimuli is believed to be the cause of this pain. It is hypothesized that dentinal tubules’ orifice occlusion (DOO) can help relieve such dental irritations. Thus, this systematic review was conducted to evaluate the effectiveness of laser application as a prevention and treatment modality on DH reduction. Methods: Electronic databases (MEDLINE, SCOPUS) were searched among randomized clinical trials from January 2007 to December 2016. The extraction of data and quality assessments were carried out by different independent observers. Results: A total of 499 items were found of which3 9 relevant articles were extracted. The profound findings proved lasers’ effectiveness as a treatment of DH. Although some of the researches reported no significant difference between laser and other desensitizing agents, most of the studies suggested that better results (both rapid and long-lasting) were obtained in combined modalities. Furthermore, the preventive role of this new technology has been emphasized as well. Nd-YAG (neodymium-doped yttrium aluminum garnet) and diode lasers reduce DH after bleaching. Lasers can also protect cervical restorations from DH due to tubular occlusion. Moreover, it is suggested to apply lasers in relief of DH following scaling and root planning. Nevertheless, a few researchers dispute its beneficence as a result of placebo effect. Conclusion: The results obtained from several studies in the present review revealed that the application of lasers is effective not only in terms of treatment of DH, but also in the prevention of this intensive tooth pain. Among various types of lasers, the application of Nd:YAG laser has shown the best results in DH treatment.

Surface degradation, margin, and bulk fracture are common reasons that necessitate replacement of resin composite restorations. The purpose of this study was to determine filler weight (FW), fracture toughness (FT), Vickers hardness (VHN), sorption/solubility (S/S), and colour change (ΔE) of four resin composites in dry and wet conditions. Four resin composites of shade A2 were investigated: Aura bulk‐fill (AB) (SDI), Tetric Evoceram (TE) (Ivoclar), G‐ænial Universal Flo (GUF) (GC), and GC Kalore (GCK) (GC). For FT, VHN, and ΔE, the specimens were prepared, divided into 2 groups, and stored dry or immersed in distilled water. The specimens were subdivided into three subgroups and stored for 1, 7, and 60 days and then subjected to the relevant tests. Six fractured remnants were weighed for each material to measure FW%. To test S/S, ISO 4049 was used. The data were analysed using ANOVA and Tukey’s test. There was an inverse correlation between FW and FT. A significantly higher FT was found for GUF. There were no significant differences between conditions in materials except for AB. The highest VHN was found for GCK and AB. After 1 and 7 days, a significant difference was observed in S/S between all materials with the highest values for GUF. There was a correlation between sorption and solubility. The material, the media, and aging have an influence on the properties of resin composites. It is important to emphasise that each material should be used for a specific clinical need based on their properties.

The aim of the present study was to compare the fracture strength and marginal adaptation of MOD cavities restored with Cention N, bonded Cention N, and resin composite, as well as to investigate the effect of cavity preparation volume on those properties. In this experimental study, 120 human maxillary premolars were randomly divided into six groups according to the type of restoration and cavity volume (n = 20): (I) conservative MOD restored with Cention N, (II) conservative MOD restored with bonded Cention N, (III) conservative MOD restored with Z250 resin composite, (IV) extended MOD restored with Cention N, (V) extended MOD restored with bonded Cention N, and (VI) extended MOD restored with Z250 resin composite. Fracture strength (MPa) was tested using a universal testing machine. To investigate marginal adaptation, polyvinyl-siloxane impressions were taken and poured with epoxy resin. Resin replicas were examined by SEM (×400) for marginal adaptation. ANOVA tests, Tukey’s test, and independent t-test were used to analyze data ( ≤ 0.05). Among conservative restorations, the fracture strength of bonded Cention N was significantly greater than that of Cention N ( = 0.001), while in the extended preparations, there was no significant difference between fracture strengths of different types of restorations ( = 0.579). In terms of marginal adaptation, there was no significant difference between different types of conservative restorations ( = 0.232). However, in extended preparations, composite showed significantly lower marginal adaptation than Cention N and bonded Cention N ( = 0.004 and = 0.045, respectively). Conservative preparations showed significantly greater fracture strength and marginal adaptation compared to extended ones in groups restored with composite. The volume of cavity preparation was shown to be effective in the materials fracture strength and marginal adaptation. Cention N showed promising results in terms of fracture strength and marginal adaptation.

The present study aimed to investigate the efficiency of passive ultrasonic irrigation (PUI), EndoActivator (EA), standard needle irrigation (SNI), and XP-endo Finisher files in removing pure calcium hydroxide (pCH) and injectable CH from in vitro root resorption cavities. Using a rotary system, the root canals of 116 extracted single rooted teeth were prepared. Imitated internal resorption cavities were then created in root halves. The specimens were divided into two groups according to the form of CH (n = 58): (I) pCH; (II) injectable CH. The teeth of each group were randomly divided into six subgroups: negative control (n = 5), positive control (n = 5), PUI (n = 12), XP-endo Finisher (n = 12), EA (n = 12), and SNI (n = 12). The root canals were irrigated using NaOCl and EDTA and split longitudinally, and both halves were evaluated with a stereomicroscope. Kruskal–Wallis and Mann–Whitney U tests were used to analyze data. The present results revealed that PUI completely removed pCH in 79% and injectable CH in 70.8% of the internal resorption cavities which was significantly higher than other methods (p<0.05). There was no statically significant difference between different forms of CH in terms of CH removal (p=0.918). The PUI technique was observed as the most efficient method of P-CH and injectable CH removal from a replicated internal resorption cavity. Finally, according to the findings, different forms of CH were comparable in terms of CH removal.

The aim of this study was to evaluate the mechanical properties of stainless steel (SS) orthodontic wires coated with zinc (Zn), using a Physical Vapored Deposition (PVD) machine. A total of 100 straight SS orthodontic wires were cut into pieces of 5 centimeters in length and were divided into two groups. Half of the wires were coated with Zn using a PVD machine, and the others remained uncoated. Tensile strength (n = 15), three-point bending (n = 15), and frictional resistance at 0° (n = 10) and 10° (n = 10) were measured to compare the mechanical properties of the Zn-coated and uncoated orthodontic wires using the universal testing machine. The surface of the coated wires was observed by SEM and AFM. An independent t-test, multivariate ANOVA, and measurement ANOVA were used for data analysis. SEM and AFM showed a homogenous Zn layer of 0.28 ± 0.006 µm on the SS wires. The tensile strength and three-point bending strength significantly increased after Zn coating of wires with the PVD method ( ). The friction resistance significantly reduced at both angulations following the coating procedure. The angle between the wire and bracket had no significant effect on the frictional resistance ( ). Coating with Zn improved the tensile and load-bending strength of SS orthodontic wires and reduced their frictional resistance which might be advantageous in terms of reducing the risk of root resorption during the orthodontic treatment.