Background: The Coronavirus disease 2019 (COVID-19) pandemic is considered a major global public health threat affecting across the life course and socioeconomic aspects of life. Global acceptance to an effective vaccine is the most anticipated resolution. This study aims to evaluate intent to be vaccinated among public in Saudi Arabia during the second wave of the COVID-19 pandemic.Methods: A cross-sectional web-based study was designed in Saudi Arabia. Study participants (N = 658) were recruited through snowball sampling. The SurveyMonkey platform was used to record the response. Cross-tabulation was performed by participants' intention to vaccinate against COVID-19 virus with sociodemographic characteristics and respondents' risk perception toward COVID-19, trust in the healthcare system, and their history of vaccine hesitancy behavior. Multivariable logistic regression analysis was performed to compute the predictors of vaccination intention among the study participants.Results: Six hundred fifty-eight participants completed the survey (females = 47.4%). Of the 658 participants, 351 (53.3%) have shown intent to be vaccinated. Five hundred nineteen (78.8%) of the participants were reported to be at high risk of COVID-19, and 307 (46.6%) were reported to trust the healthcare system in the country. The multivariable analysis shows respondents with a high-risk perception (OR: 2.27, 95% CI: 1.49–3.48); higher trust in the healthcare system (OR: 3.24, 95% CI: 2.32–4.61) was found to be the significant factor affecting the decision in acceptance of the COVID-19 vaccine in Saudi Arabia.Conclusion: Participants reported high knowledge toward COVID-19 virus, and vaccine developments. About half (46.6%) of the study participants reported refusal/hesitancy toward the vaccine during the second wave of the pandemic in Saudi Arabia. The study highlighted that higher risk perception and higher trust in the healthcare system were found to be the main reasons for participants' intentions behind the vaccination.

Objectives: The present study aimed to investigate parents’ willingness to vaccinate their children under the age of 18 with a COVID-19 vaccine. Methods: This cross-sectional study was conducted in Saudi Arabia from January 2021 to March 2021. The univariate analysis using Mann–Whitney U-test, t-test, and chi-squared/Fisher’s exact test was performed to identify sociodemographic factors associated with the acceptance of COVID-19 vaccine in children. Factors with statistical significance (p < 0.05) were analyzed using multivariate regression analysis to determine the variables affecting parents’ decisions to vaccinate children. Results: Overall, 44% (167) of parents reported that they would accept vaccinating their children with a COVID-19 vaccine. Young (86; 22.7%), married (135; 35.6%), and Saudi (114; 30%) parents seemed to be more concerned about their children being infected. Parents who intended to vaccinate themselves (OR: 0.599, 95% CI: 0.367–0.980) and who trust the healthcare system (OR: 0.527, 95% CI: 0.327–0.848) reported greater acceptance of children’s vaccination. Among parents, the most frequent (40.9%) reason for vaccinating children was to prevent infection in other family members. What may underlie this result is that some parents understand that children can carry pathogens from persons in school to thoseat home. The most frequent (22.2%) reason for refusing vaccination was concerns about the side effects of the vaccine. Conclusions: Parents have differing opinions on frequencies and risks of coronavirus disease transmission and medical complications and of effectiveness and adverse effects of a vaccine. These results could be of use in designing public health information campaigns and health promotion programs based on perceived parental behavior and positive attitudes.