The Tibetan Plateau (TP) and the Arctic are both cold, fragile, and sensitive to global warming. However, they have very different cloud radiative effects (CRE) and influences on the climate system. In this study, the effects of cloud microphysics on the vertical structures of CRE over the two regions are analyzed and compared by using CloudSat/CALIPSO satellite data and the Rapid Radiative Transfer Model. Results show there is a greater amount of cloud water particles with larger sizes over the TP than over the Arctic, and the supercooled water is found to be more prone to exist over the former than the latter, making shortwave and longwave CRE, as well as the net CRE, much stronger over the TP. Further investigations indicate that the vertical structures of CRE at high altitudes are primarily dominated by cloud ice water, while those at low altitudes are dominated by cloud liquid and mixed-phase water. The liquid and mixed-phase water results in a strong shallow heating (cooling) layer above the cooling (heating) layer in the shortwave (longwave) CRE profiles, respectively.