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Zahra Ramezani
Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 6135733184, Iran

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Journal article
Published: 13 July 2021 in COVID
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The interaction of the spike (S) glycoprotein of SARS-CoV-2 with angiotensin-converting enzyme 2 (ACE2) correlates with increased virus transmissibility and disease severity in humans. Two strategies may be considered for preventive or treatment purposes: the blockage of the ACE2 receptors or the shielding of receptor-binding domains (RBD) in the Sprotein of COVID-19, as well as the S2 cleavage site that is used by the furin enzyme of the host cells in the late phase of virus activation. Herein, the interaction of carbon quantum dots (CQDs) with the Sprotein of SARS-CoV-2 was investigated using molecular docking and molecular dynamics. CQD molecules were optimized by the HF/3-21G level of theory; the probable interactions between the CQDs with Sprotein were studied by blind docking mode, considering the Sprotein as the receptor and CQDs as ligands. Ethanol, folic acid, Favipiravir, two kinds of functionalized triangular hexagonal graphene, and four kinds of functionalized CQDs were studied on a comparative basis. The results show that OH and amine-functionalized CQDs tend to interact with three branches of Sprotein, especially RBD. The fact that they can block the S2 cleavage site leads to their potential use as a therapeutic agent.

ACS Style

Zahra Ramezani; Mohammad Dayer; Siamak Noorizadeh; Michael Thompson. Deactivation of SARS-CoV-2 via Shielding of Spike Glycoprotein Using Carbon Quantum Dots: Bioinformatic Perspective. COVID 2021, 1, 120 -129.

AMA Style

Zahra Ramezani, Mohammad Dayer, Siamak Noorizadeh, Michael Thompson. Deactivation of SARS-CoV-2 via Shielding of Spike Glycoprotein Using Carbon Quantum Dots: Bioinformatic Perspective. COVID. 2021; 1 (1):120-129.

Chicago/Turabian Style

Zahra Ramezani; Mohammad Dayer; Siamak Noorizadeh; Michael Thompson. 2021. "Deactivation of SARS-CoV-2 via Shielding of Spike Glycoprotein Using Carbon Quantum Dots: Bioinformatic Perspective." COVID 1, no. 1: 120-129.

Paper
Published: 21 April 2021 in RSC Advances
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Electrospun polyacrylonitrile/reduced graphene oxide-amino-halloysite/bimetallic metal–organic framework nanofiber film was synthesized and successfully applied to the ultrasonic-assisted thin-film microextraction (UA-TFME) of fatty acid methyl esters from dairy products.

ACS Style

R. Mirzajani; F. Kardani; Z. Ramezani. The fabrication of a novel polyacrylonitrile/reduced graphene oxide-amino-halloysite/bimetallic metal–organic framework electrospun nanofiber adsorbent for the ultrasonic-assisted thin-film microextraction of fatty acid methyl esters in dairy products with gas chromatography-flame ionization detection. RSC Advances 2021, 11, 14686 -14699.

AMA Style

R. Mirzajani, F. Kardani, Z. Ramezani. The fabrication of a novel polyacrylonitrile/reduced graphene oxide-amino-halloysite/bimetallic metal–organic framework electrospun nanofiber adsorbent for the ultrasonic-assisted thin-film microextraction of fatty acid methyl esters in dairy products with gas chromatography-flame ionization detection. RSC Advances. 2021; 11 (24):14686-14699.

Chicago/Turabian Style

R. Mirzajani; F. Kardani; Z. Ramezani. 2021. "The fabrication of a novel polyacrylonitrile/reduced graphene oxide-amino-halloysite/bimetallic metal–organic framework electrospun nanofiber adsorbent for the ultrasonic-assisted thin-film microextraction of fatty acid methyl esters in dairy products with gas chromatography-flame ionization detection." RSC Advances 11, no. 24: 14686-14699.

Article
Published: 25 March 2021 in Food Analytical Methods
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Staphylococcal enterotoxin A (SEA) is an exotoxin that releases from gram-positive bacteria, and it is a source of food poisoning. Here, the luminescence method is introduced to quantify and detect SEA using carbon quantum dots (CQDs) as fluorophore; SEA antibody loaded Fe3O4 nanoparticles ([email protected]) are prepared for SEA extraction. SEA in standards and milk samples were conjugated with [email protected] ([email protected]@SEA), separated by a 1.4 T magnet, and dispersed in phosphate buffer saline. The fluorescence of CQDs is quenched when mixed with [email protected]@SEA, without elution of SEAs from the [email protected]@SEA. It is a fast and reliable method compared with the immunoassay counterpart. At optimum quantification conditions, a linear relationship between SEAs concentration and CQDs fluorescent quenching was observed from 4 to 2000 pg mL−1 with the detection limit 2 pg mL−1. Repeatability and reproducibility were calculated as a percentage of relative standard deviations and were from 1.56 to 11.76%. Finally, the proposed method was applied to measure the SEA contents of four sterilized and homogenized milk samples without fat precipitations and have shown significant reliability.

ACS Style

Masoud Veissi; Siavash Maktabi; Zahra Ramezani; Mohammad Khosravi. Highly Sensitive Fluorescence Assay of Enterotoxin A in Milk Using Carbon Quantum Dots as a Fluorophore. Food Analytical Methods 2021, 1 -11.

AMA Style

Masoud Veissi, Siavash Maktabi, Zahra Ramezani, Mohammad Khosravi. Highly Sensitive Fluorescence Assay of Enterotoxin A in Milk Using Carbon Quantum Dots as a Fluorophore. Food Analytical Methods. 2021; ():1-11.

Chicago/Turabian Style

Masoud Veissi; Siavash Maktabi; Zahra Ramezani; Mohammad Khosravi. 2021. "Highly Sensitive Fluorescence Assay of Enterotoxin A in Milk Using Carbon Quantum Dots as a Fluorophore." Food Analytical Methods , no. : 1-11.

Journal article
Published: 20 March 2021 in Talanta
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In this study, sarcosine metal-coded hydrogel magnetic molecularly imprinted polymer (Hydro-MeC-MMIP) has been fabricated and coupled to on-column derivatization capillary electrophoresis (CE). As a metal-coding approach, sarcosine˗Cu2+˗ligand (Sar˗Cu2+˗L) chelate complex was introduced as a template to overcome the problems associated with the fabrication of MMIP for a small molecule having limited functional groups such as sarcosine. To our best knowledge, it is the first time that methacrylamide (MA) coated Fe3O4 ([email protected]) with abounded reactive double-bound on the surface has been used as a magnetic core in the one-pot synthesis of MMIPs. As prepared, Hydro-MeC-MMIP was characterized by different microscopic, spectroscopic, and thermal gravimetric methods. Hydro-MeC-MMIP was used to extract and preconcentrate sarcosine in the urine sample with no treatment and dilution. Sarcosine was quantified by on-column derivatization capillary electrophoresis equipped with a photodiode array detector. A mixture of thirteen amino acids was separated with a total run time of 12 min. Three structural analogs, including alanine, sarcosine, and glycine, were significantly resolved. Under optimal experimental conditions, the method's detection and quantification limits were 9.93 and 33.10 ng mL-1, respectively. The linear range of 50–2000 ng mL−1 and 96% recovery, along with the relative standard deviation of 6.07% (n = 6) for the target amino acid, were obtained. This method provides a simple, low-cost, fast, and efficient tool for extracting and quantifying sarcosine in the urine. The present method can address inconsistency in evaluating sarcosine as a candidate biomarker for prostate cancer with a simple CE/UV; no need for a sophisticated detection system such as a mass spectrometer.

ACS Style

Zahra Ramezani; Mehdi Safdarian; Ata A. Ghadiri. Metal-coded hydrogel magnetic molecularly imprinted polymer for preconcentration and cleanup of sarcosine: Determination in urine; coupled to on-column capillary electrophoresis. Talanta 2021, 230, 122309 .

AMA Style

Zahra Ramezani, Mehdi Safdarian, Ata A. Ghadiri. Metal-coded hydrogel magnetic molecularly imprinted polymer for preconcentration and cleanup of sarcosine: Determination in urine; coupled to on-column capillary electrophoresis. Talanta. 2021; 230 ():122309.

Chicago/Turabian Style

Zahra Ramezani; Mehdi Safdarian; Ata A. Ghadiri. 2021. "Metal-coded hydrogel magnetic molecularly imprinted polymer for preconcentration and cleanup of sarcosine: Determination in urine; coupled to on-column capillary electrophoresis." Talanta 230, no. : 122309.

Journal article
Published: 17 July 2020 in Clinical Epidemiology and Global Health
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Nasal polyposis (NP) is an inflammatory condition in nasal and paranasal sinus cavities and its pathophysiology is poorly understood. It seems likely that the trace elements such as zinc and selenium may play a critical role in the genesis of inflammatory sinonasal disease. The aim of this study was to investigate the role of these elements in NP and compare these findings with normal nasal mucosa. In this descriptive-analytic cross-sectional study which was done at Imam Khomeini hospital of Ahvaz between July 2018 and June 2019, selenium and zinc levels measured in polyp tissues of 72 patients (47 men and 25 women) and were compared with healthy nasal mucosa of 36 control cases (15 men and 21 women). Hydride generation and flame atom absorption spectroscopy were utilized for selenium and zinc quantifications, consequently. The mean tissue zinc and selenium levels were, respectively, 18.569 μg/g and 68.65 ng/g in patients group and 71.015 μg/g, 249.53 ng/g in control group. It was found that the concentrations of zinc element were significantly lower in polyp tissues than healthy nasal mucosa. In the case of selenium no significant difference was found between patients and controls. Trace elements are undoubtedly useful, and further studies are needed to determine the effect of zinc and selenium on nasal and sinus polyps.

ACS Style

Soheila Nikakhlagh; Zahra Ramezani; Ayeh Kiani. Comparison of tissue level of selenium and zinc in patients with nasal polyposis and healthy people. Clinical Epidemiology and Global Health 2020, 9, 87 -89.

AMA Style

Soheila Nikakhlagh, Zahra Ramezani, Ayeh Kiani. Comparison of tissue level of selenium and zinc in patients with nasal polyposis and healthy people. Clinical Epidemiology and Global Health. 2020; 9 ():87-89.

Chicago/Turabian Style

Soheila Nikakhlagh; Zahra Ramezani; Ayeh Kiani. 2020. "Comparison of tissue level of selenium and zinc in patients with nasal polyposis and healthy people." Clinical Epidemiology and Global Health 9, no. : 87-89.

Original paper
Published: 16 May 2020 in Journal of the Iranian Chemical Society
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Third-generation polyamidoamine (G3 PAMAM) dendrimer–digoxin (PAMAM-Dig) is prepared, and conjugation is confirmed by 1H-NMR, Fourier transform infrared spectroscopy (FT-IR), and thermal analysis. Then, PAMAM-Dig impregnated polyvinyl chloride (PAMAM-Dig/PVC) film has been prepared by mixing PAMAM-Dig, PVC powder, and 2-nitrophenyl octyl ether (O-NPOE) as the plasticizer in tetrahydrofuran. Differential scanning calorimetry (DSC) evaluation shows the as-prepared film is thermally stable below 200 °C. The film is mounted above the powder as well as the essential oil of Thymus vulgaris. The Taguchi orthogonal array is used to optimize the experimental conditions for adsorption of volatile constituents. At optimized conditions, the obtained fingerprint was the same or better than static headspace sampling of the essential oil. The chromatogram pattern had also obtained by floating the fiber in the essential oil, and more components have observed. Film-to-film variations were less than 10%. All obtained patterns are compared with those of different solvent extracts of Thymus vulgaris. It is concluded that PAMAM-Dig/PVC film could apply for fingerprint analysis of herbs’ volatile and semi-volatile constituents with no need for prior extraction.

ACS Style

Eskandar Moghimipour; Zahra Ramezani; Somayeh Handali; Ahmad Babapoor. Polyamidoamine dendrimer–digoxin impregnated PVC film in the fingerprint detection of herbs’ essential oil coupled to gas chromatography–mass spectrometry. Journal of the Iranian Chemical Society 2020, 17, 2545 -2553.

AMA Style

Eskandar Moghimipour, Zahra Ramezani, Somayeh Handali, Ahmad Babapoor. Polyamidoamine dendrimer–digoxin impregnated PVC film in the fingerprint detection of herbs’ essential oil coupled to gas chromatography–mass spectrometry. Journal of the Iranian Chemical Society. 2020; 17 (10):2545-2553.

Chicago/Turabian Style

Eskandar Moghimipour; Zahra Ramezani; Somayeh Handali; Ahmad Babapoor. 2020. "Polyamidoamine dendrimer–digoxin impregnated PVC film in the fingerprint detection of herbs’ essential oil coupled to gas chromatography–mass spectrometry." Journal of the Iranian Chemical Society 17, no. 10: 2545-2553.

Articles
Published: 16 January 2020 in Grana
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Ahvaz city in Iran was designated as the most polluted city in the world in 2013 that suffered from a lot of dust storms. Conocarpus erectus is currently the dominant tree species in Ahvaz. In this study, ripe and young inflorescences of plants grown in three cities of the Khuzestan province on dust storm days and clean days (days with no dust storm) were selected and the stamina were separated. Pollen grains were checked in a scanning electron microscope and analysis of the elements existing on the surface of the anthers and pollen grains was accomplished using energy-dispersive X-ray spectroscopy. Results showed that the pollen grains are small-sized monads and the mature pollen has six lobes in a polar view and has six heterocolpate apertures (three colpates and three colporates, one alternating the other) with a polar axis length (P) of 12.998 ± 1.516 μm and an equatorial axis length (E) of 8.698 ± 0.557 μm. The dense Calcite crystals (CaCO3) and particulate matters smaller than 2.5 μm in size including the fragments containing elements such as aluminium, silicon and iron, which are components of soils were attached to all parts of those pollen grains which were collected after dust storms. The crushed pieces of calcite crystals were also seen in the pollen apertures.

ACS Style

Foroogh Namjoyan; Massoumeh Farasat; Shadi Kiabi; Zahra Ramezani; Hamideh Mousavi. Structural and ultra-structural analysis of Conocarpus erectus pollen grains before and after dust storms. Grana 2020, 59, 226 -237.

AMA Style

Foroogh Namjoyan, Massoumeh Farasat, Shadi Kiabi, Zahra Ramezani, Hamideh Mousavi. Structural and ultra-structural analysis of Conocarpus erectus pollen grains before and after dust storms. Grana. 2020; 59 (2-3):226-237.

Chicago/Turabian Style

Foroogh Namjoyan; Massoumeh Farasat; Shadi Kiabi; Zahra Ramezani; Hamideh Mousavi. 2020. "Structural and ultra-structural analysis of Conocarpus erectus pollen grains before and after dust storms." Grana 59, no. 2-3: 226-237.

Journal article
Published: 10 January 2020 in Food Chemistry
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In this study, for the first time, hollow fiber and monolithic fiber were fabricated based on metal-organic framework deep eutectic solvents/molecularly imprinted polymers (MOF- DES/MIPs) and were used for microextraction of phthalate esters under termed hollow fiber liquid membrane-protected solid-phase microextraction (HFLMP-SPME) followed by gas chromatography- flame ionization detection. Several parameters influencing extraction recoveries of phthalate esters including adsorption and desorption parameters were investigated and optimized using fabricated MOF- DES/MIPs monolithic fiber. Under optimal conditions, detection limits (S/N = 3) of the method were in a range of 0.008–0.03 µg L−1 and limits of quantification (S/N = 10) were between 0.028 and 0.12 µg L−1. RSD (%) for intra-day and inter-day precisions were between 2.4–4.7% and 2.6–3.4%, respectively. Subsequently, this procedure was successfully applied with satisfactory results in the determination of phthalate esters in yogurt, water, and soybean oil samples. The R (%) ranged from 95.5 to 100.0% in different samples.

ACS Style

Roya Mirzajani; Fatemeh Kardani; Zahra Ramezani. Fabrication of UMCM-1 based monolithic and hollow fiber – Metal-organic framework deep eutectic solvents/molecularly imprinted polymers and their use in solid phase microextraction of phthalate esters in yogurt, water and edible oil by GC-FID. Food Chemistry 2020, 314, 126179 .

AMA Style

Roya Mirzajani, Fatemeh Kardani, Zahra Ramezani. Fabrication of UMCM-1 based monolithic and hollow fiber – Metal-organic framework deep eutectic solvents/molecularly imprinted polymers and their use in solid phase microextraction of phthalate esters in yogurt, water and edible oil by GC-FID. Food Chemistry. 2020; 314 ():126179.

Chicago/Turabian Style

Roya Mirzajani; Fatemeh Kardani; Zahra Ramezani. 2020. "Fabrication of UMCM-1 based monolithic and hollow fiber – Metal-organic framework deep eutectic solvents/molecularly imprinted polymers and their use in solid phase microextraction of phthalate esters in yogurt, water and edible oil by GC-FID." Food Chemistry 314, no. : 126179.

Articles
Published: 20 November 2019 in Pharmaceutical Development and Technology
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5-FU is one of the most widely used agents in the first-line chemotherapy for colon cancer. However, clinical use of 5-FU is limited because of the low efficacy of drug uptake and systemic toxic effects. Therefore, there is a critical need to find better drug delivery systems in order to improve the efficacy of the drug. In present study, we have developed a novel combination drug delivery system based on PHBV/PLGA NPs for delivery of 5-FU to cancer cells. NPs were prepared by the double emulsion method and their optimization of preparation was evaluated using Box-Behnken design (BBD) of response surface methodology (RSM). 5-FU loaded NPs were characterized by SEM, DSC, TGA and FT-IR. SEM image implied that NPs were spherical in shape and the results of DSC, TGA and FT-IR suggest that 5-FU was encapsulated into NPs. The obtained results revealed that 5-FU loaded PHBV/PLGA NPs induced significant higher cell death at concentration much lower than free 5-FU. Results of hemolysis assay indicated that the NPs were hemo-compatible. In vivo anti-tumor studies showed that 5-FU loaded NPs reduced tumor volume significantly in comparison with free 5-FU. As the first example of using PHBV/PLGA as nano-drug delivery system with enhanced anti-tumor activities, this study establishes PHBV/PLGA as a novel promising drug delivery platform for treatment of colon cancer.

ACS Style

Somayeh Handali; Eskandar Moghimipour; Mohsen Rezaei; Zahra Ramezani; Farid Abedin Dorkoosh. PHBV/PLGA nanoparticles for enhanced delivery of 5-fluorouracil as promising treatment of colon cancer. Pharmaceutical Development and Technology 2019, 25, 206 -218.

AMA Style

Somayeh Handali, Eskandar Moghimipour, Mohsen Rezaei, Zahra Ramezani, Farid Abedin Dorkoosh. PHBV/PLGA nanoparticles for enhanced delivery of 5-fluorouracil as promising treatment of colon cancer. Pharmaceutical Development and Technology. 2019; 25 (2):206-218.

Chicago/Turabian Style

Somayeh Handali; Eskandar Moghimipour; Mohsen Rezaei; Zahra Ramezani; Farid Abedin Dorkoosh. 2019. "PHBV/PLGA nanoparticles for enhanced delivery of 5-fluorouracil as promising treatment of colon cancer." Pharmaceutical Development and Technology 25, no. 2: 206-218.

Journal article
Published: 28 August 2019 in Catalysis Today
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Nanoparticles of TiO2 with different ratios of anatase (A)/rutile (R) phases were successfully synthesized via sole-gel method. Carbon-doped TiO2 (CDT) was supported on the surfaces of granular activated carbon (GAC) for photocatalytic degradation and mineralization of the commercial nonylphenol (NP) surfactant under visible light irradiation. The physicochemical characteristics of the synthesized composites (TiO2, CDT, and CDT/GAC) were determined in detail by X-ray diffraction, scanning electron microscopy, elemental mapping, Brunauer–Emmett–Teller, UV–Vis absorption and PL spectra. The results indicated that the band gap decreased from 3.17 eV to 2.72 eV after C doping, and to 2.66 eV by changing the calcination temperature from 475 °C to 600 °C; the visible light absorption also increased. This study demonstrates that the CDT/GAC photocatalyst with an A (53.06)/R (46.94) ratio exhibited high degradation efficiency. COD and TOC removal of 99 % and 89 %, respectively, and 80 % NP decrease within 60 min. The NP degradation increases with increasing temperature and light intensity. The Langmuir–Hinshelwood kinetic model fitted with the experimental data. In addition, it is reported that the synthesized photocatalyst became stable and highly active, even after five cycles. The results also showed that the values of the carbon oxidation state (COS) and the average oxidation state (AOS) were highly increased after the decomposition of NP by the Xenon/CDT (A/R)/GAC process over 3.37 and 3.87, respectively.

ACS Style

Zahra Noorimotlagh; Iraj Kazeminezhad; Neemat Jaafarzadeh; Mehdi Ahmadi; Zahra Ramezani. Improved performance of immobilized TiO2 under visible light for the commercial surfactant degradation: Role of carbon doped TiO2 and anatase/rutile ratio. Catalysis Today 2019, 348, 277 -289.

AMA Style

Zahra Noorimotlagh, Iraj Kazeminezhad, Neemat Jaafarzadeh, Mehdi Ahmadi, Zahra Ramezani. Improved performance of immobilized TiO2 under visible light for the commercial surfactant degradation: Role of carbon doped TiO2 and anatase/rutile ratio. Catalysis Today. 2019; 348 ():277-289.

Chicago/Turabian Style

Zahra Noorimotlagh; Iraj Kazeminezhad; Neemat Jaafarzadeh; Mehdi Ahmadi; Zahra Ramezani. 2019. "Improved performance of immobilized TiO2 under visible light for the commercial surfactant degradation: Role of carbon doped TiO2 and anatase/rutile ratio." Catalysis Today 348, no. : 277-289.

Journal article
Published: 16 April 2019 in Life Sciences
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We previously showed that folate liposomes of 5FU made from Dipalmitoylphosphatidylcholine (DPPC) induced cell death in HT-29 and HeLa cells more potently than bulk 5FU. Also, a primary 5FU liposomal formulation with phosphatidyl choline (PC) exhibited higher cytotoxicity in murine colon cancer cells. In the present study, optimization of 5FU PC liposome, mechanism of cell death induction in human cancer cell lines and its safety along with other assays have been employed for targeted PC liposomes of 5FU. Liposomes were prepared using thin layer method and optimization of preparation was assessed using central composite design (CCD) of response surface methodology (RSM). Folic acid (FA) was employed as the targeting ligand. Morphology of 5FU loaded liposomes and changes in their thermal behavior were assessed by transmission electron microscopy (TEM) and differential scanning calorimetry (DSC), respectively. In vitro cytotoxicity was explored using MTT assay in HT-29, Caco-2, HeLa and MCF-7 cell lines. Cytotoxicity mechanism of the targeted delivery system was searched through the evaluation of reactive oxygen species (ROS) overproduction, mitochondrial membrane potential (∆Ψm), the release of cytochrome c, the activity of caspase 3/7 and apoptosis and necrosis rate. Liposomes were spherical in shape and 5FU was successfully encapsulated into liposomes rather in an amorphous state. Our interesting results showed that in HT-29 cells targeted liposomes triggered the mitochondrial apoptotic pathway by decreasing the mitochondrial membrane potential, releasing of cytochrome c and promoting the substantial activity of caspase 3/7. In HeLa cells, however, targeted liposomes particularly activated necrosis pathway through the overproduction of ROS. Folate-liposomal 5FU showed significantly higher antitumor efficiency compared to free drug. The results of this study offer new prospects for cancer therapy with reducing systemic drug exposure and associated toxicities.

ACS Style

Somayeh Handali; Eskandar Moghimipour; Maryam Kouchak; Zahra Ramezani; Mohsen Amini; Kambiz Ahmadi Angali; Sadegh Saremy; Farid Abedin Dorkoosh; Mohsen Rezaei. New folate receptor targeted nano liposomes for delivery of 5-fluorouracil to cancer cells: Strong implication for enhanced potency and safety. Life Sciences 2019, 227, 39 -50.

AMA Style

Somayeh Handali, Eskandar Moghimipour, Maryam Kouchak, Zahra Ramezani, Mohsen Amini, Kambiz Ahmadi Angali, Sadegh Saremy, Farid Abedin Dorkoosh, Mohsen Rezaei. New folate receptor targeted nano liposomes for delivery of 5-fluorouracil to cancer cells: Strong implication for enhanced potency and safety. Life Sciences. 2019; 227 ():39-50.

Chicago/Turabian Style

Somayeh Handali; Eskandar Moghimipour; Maryam Kouchak; Zahra Ramezani; Mohsen Amini; Kambiz Ahmadi Angali; Sadegh Saremy; Farid Abedin Dorkoosh; Mohsen Rezaei. 2019. "New folate receptor targeted nano liposomes for delivery of 5-fluorouracil to cancer cells: Strong implication for enhanced potency and safety." Life Sciences 227, no. : 39-50.

Original article
Published: 21 February 2019 in Comparative Clinical Pathology
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Cystic echinococcosis (CE), a serious public health problem worldwide, is caused by the larval stage of Echinococcus granulosus (E. granulosus). Despite recent progress in the CE medical treatment, this subject still remains as a priority of research. Albendazole (ABZ) is a drug of choice for the treatment of hydatidosis. Its use as an antiparasitic agent with the most efficacy is limited by the lack of water solubility. Therefore, the aim of the present study was to compare in vitro efficacy of free and solid lipid nanoparticles (SLNs) of ABZ and albendazole sulfoxide (ABZSO) against fertile and infertile hydatid cysts in terms of ultrastructural changes. ABZ-SLN and ABZSO-SLN were produced by micro emulsification and high shear homogenization technique and the physicochemical characterization of the product was evaluated. Then, the structural alterations occurring due to treatment with free and SLN formulations against fertile and infertile sheep liver hydatid cysts were assessed by optical and transmission electron microscopy (TEM) examinations. Untreated control groups revealed the typical appearance of hydatid cysts; in contrast, all treated cysts exhibited degenerative alterations with various rates. Loading ABZ and ABZSO into SLN leads to greater structural changes. In both prepared formulations, better efficacy was observed in fertile and small cysts.

ACS Style

Abdollah Rafiei; Shahrzad Soltani; Zahra Ramezani; Mohammadreza Abbaspour; Ali Jelowdar; Mehdi Sagha Kahvaz. Ultrastructural changes on fertile and infertile hydatid cysts induced by conventional and solid lipid nanoparticles of albendazole and albendazole sulfoxide. Comparative Clinical Pathology 2019, 28, 1045 -1053.

AMA Style

Abdollah Rafiei, Shahrzad Soltani, Zahra Ramezani, Mohammadreza Abbaspour, Ali Jelowdar, Mehdi Sagha Kahvaz. Ultrastructural changes on fertile and infertile hydatid cysts induced by conventional and solid lipid nanoparticles of albendazole and albendazole sulfoxide. Comparative Clinical Pathology. 2019; 28 (4):1045-1053.

Chicago/Turabian Style

Abdollah Rafiei; Shahrzad Soltani; Zahra Ramezani; Mohammadreza Abbaspour; Ali Jelowdar; Mehdi Sagha Kahvaz. 2019. "Ultrastructural changes on fertile and infertile hydatid cysts induced by conventional and solid lipid nanoparticles of albendazole and albendazole sulfoxide." Comparative Clinical Pathology 28, no. 4: 1045-1053.

Original paper
Published: 01 February 2019 in Microchimica Acta
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A method is described for multiple monolithic fiber solid-phase microextraction of five sterol and steroid hormones from complex food samples. A composite was prepared from graphene oxide, a metal-organic framework (ZIF-8) and a molecularly imprinted polymers was deposited on a single thin fiber. Four thin fibers were combined to obtain a fiber bundle. The nanocomposite was characterized by Fourier transform infrared spectroscopy, powder X-ray diffraction, scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy. The parameters affecting the extraction were optimized by Box-Behnken design. Following elution with methanol, the analytes progesterone, testosterone, β-sitosterol, cholesterol and campesterol were quantified via HPLC. Response is linear in the 0.01–1000 μg L−1 concentration range, and limits of detection range from 3 to 5 ng L−1. The method was successfully applied to the determination of the five analytes in spiked samples of white meat, egg yolks and vegetables. The relative mean recoveries ranged from 95.0% to 101.0%.

ACS Style

Roya Mirzajani; Fatemeh Kardani; Zahra Ramezani. A nanocomposite consisting of graphene oxide, zeolite imidazolate framework 8, and a molecularly imprinted polymer for (multiple) fiber solid phase microextraction of sterol and steroid hormones prior to their quantitation by HPLC. Microchimica Acta 2019, 186, 129 .

AMA Style

Roya Mirzajani, Fatemeh Kardani, Zahra Ramezani. A nanocomposite consisting of graphene oxide, zeolite imidazolate framework 8, and a molecularly imprinted polymer for (multiple) fiber solid phase microextraction of sterol and steroid hormones prior to their quantitation by HPLC. Microchimica Acta. 2019; 186 (3):129.

Chicago/Turabian Style

Roya Mirzajani; Fatemeh Kardani; Zahra Ramezani. 2019. "A nanocomposite consisting of graphene oxide, zeolite imidazolate framework 8, and a molecularly imprinted polymer for (multiple) fiber solid phase microextraction of sterol and steroid hormones prior to their quantitation by HPLC." Microchimica Acta 186, no. 3: 129.

Journal article
Published: 01 January 2019 in Desalination and Water Treatment
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ACS Style

Fatemeh Kardani; Roya Mirzajani; Zahra Ramezani. Determination of nanomolar dissolved polycyclic aromatic hydrocarbons in different water and wastewater samples using a metal-organic [email protected] oxide fiber and headspace solid-phase microextraction. Desalination and Water Treatment 2019, 144, 99 -115.

AMA Style

Fatemeh Kardani, Roya Mirzajani, Zahra Ramezani. Determination of nanomolar dissolved polycyclic aromatic hydrocarbons in different water and wastewater samples using a metal-organic [email protected] oxide fiber and headspace solid-phase microextraction. Desalination and Water Treatment. 2019; 144 ():99-115.

Chicago/Turabian Style

Fatemeh Kardani; Roya Mirzajani; Zahra Ramezani. 2019. "Determination of nanomolar dissolved polycyclic aromatic hydrocarbons in different water and wastewater samples using a metal-organic [email protected] oxide fiber and headspace solid-phase microextraction." Desalination and Water Treatment 144, no. : 99-115.

Journals
Published: 19 November 2018 in New Journal of Chemistry
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Microwave-assisted distillation–precipitation polymerization (MWDPP) for the synthesis of magnetic molecularly imprinted polymers (MMIPs) under atmospheric pressure is reported.

ACS Style

Mehdi Safdarian; Zahra Ramezani. Rapid microwave-assisted distillation–precipitation polymerization for the synthesis of magnetic molecular imprinted polymers coupled to HPTLC determination of perphenazine in human urine. New Journal of Chemistry 2018, 43, 48 -57.

AMA Style

Mehdi Safdarian, Zahra Ramezani. Rapid microwave-assisted distillation–precipitation polymerization for the synthesis of magnetic molecular imprinted polymers coupled to HPTLC determination of perphenazine in human urine. New Journal of Chemistry. 2018; 43 (1):48-57.

Chicago/Turabian Style

Mehdi Safdarian; Zahra Ramezani. 2018. "Rapid microwave-assisted distillation–precipitation polymerization for the synthesis of magnetic molecular imprinted polymers coupled to HPTLC determination of perphenazine in human urine." New Journal of Chemistry 43, no. 1: 48-57.

Original paper
Published: 29 October 2018 in Journal of the Iranian Chemical Society
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The aim of the present study was to develop a novel HPLC method for the simultaneous determination of 5-fluorouracil (5-FU) and oxaliplatin (OXA) in the PHBV/PLGA nanoparticles (NPs). Chromatographic separation was performed using C18 column at a detection wavelength of 260 nm. The mobile phase consisted of 0.02 M phosphate buffer (pH 4) and methanol (90:10, V/V) and flow rate was 0.8 mL min−1. Column temperature was also maintained at 30 °C. The calibration curves displayed linear concentration ranges of 0.05–40 µg mL−1 for 5-FU and 0.5–80 µg mL−1 for OXA with correlation coefficients of 0.998. The LOD and LOQ were, respectively, 0.01 and 0.03 µg mL−1 for 5-FU and 0.13 and 0.44 µg mL−1 for OXA. The values of intra- and inter-day precision and accuracy were within acceptable limits. According to the results, the method was found to be simple, reliable, rapid, and reproducible. In addition, the HPLC assay method presented was successfully applied to the simultaneous determination of 5-FU and OXA in PHBV/PLGA NPs.

ACS Style

Somayeh Handali; Zahra Ramezani; Eskandar Moghimipour; Mohsen Rezaei; Farid Abedin Dorkoosh. A novel method for the simultaneous determination of 5-fluorouracil and oxaliplatin in new biodegradable PHBV/PLGA nanoparticles. Journal of the Iranian Chemical Society 2018, 16, 609 -615.

AMA Style

Somayeh Handali, Zahra Ramezani, Eskandar Moghimipour, Mohsen Rezaei, Farid Abedin Dorkoosh. A novel method for the simultaneous determination of 5-fluorouracil and oxaliplatin in new biodegradable PHBV/PLGA nanoparticles. Journal of the Iranian Chemical Society. 2018; 16 (3):609-615.

Chicago/Turabian Style

Somayeh Handali; Zahra Ramezani; Eskandar Moghimipour; Mohsen Rezaei; Farid Abedin Dorkoosh. 2018. "A novel method for the simultaneous determination of 5-fluorouracil and oxaliplatin in new biodegradable PHBV/PLGA nanoparticles." Journal of the Iranian Chemical Society 16, no. 3: 609-615.

Journal article
Published: 03 October 2018 in Biomedicine & Pharmacotherapy
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The aim of this study was to develop and characterize 5-Fluorouracil (5FU) containing targeted liposomes in order to enhance the efficacy and safety of the drug. Folic acid (FA) was used as a targeting ligand. The in vitro cytotoxicity of formulation against HT-29, Caco-2, CT26, HeLa and MCF-7 cell lines was evaluated using MTT assay. Mechanism of cell death induced by targeted liposomes was further investigated via the production of reactive oxygen species (ROS), change in mitochondrial membrane potential (ΔΨm), release of cytochrome c and activity of caspase 3/7. The in vivo tumor inhibition study was also performed after administration of drug and targeted 5FU liposome. The encapsulation efficiency (EE%) of the optimized formulation was 39.71%. Particle size of liposomes was around 174 nm and the nanoparticles were found to be spherical in shape. Differential Scanning Calorimetry (DSC) results indicated that the drug remained in an amorphous state in liposomes. According to the MTT results, targeted liposomes exhibited higher cytotoxicity than 5FU and liposomal 5FU. Targeted liposomes were found to trigger necrosis in HT-29 cells; while, in HeLa cells, targeted liposomes activated apoptotic pathway by collapse of ΔΨm, increased activity of cytochrome c as well as caspases activity. in vivo results showed that targeted liposomes reduced tumor volume significantly in comparison with 5FU (169.00 mm3 tumor volume vs 326.40 mm3). From these findings, it can be concluded that folic acid targeted liposomes may provide a new platform for selective delivery of drugs to cancer cells.

ACS Style

Somayeh Handali; Eskandar Moghimipour; Mohsen Rezaei; Zahra Ramezani; Maryam Kouchak; Mohsen Amini; Kambiz Ahmadi Angali; Sadegh Saremy; Farid Abedin Dorkoosh. A novel 5-Fluorouracil targeted delivery to colon cancer using folic acid conjugated liposomes. Biomedicine & Pharmacotherapy 2018, 108, 1259 -1273.

AMA Style

Somayeh Handali, Eskandar Moghimipour, Mohsen Rezaei, Zahra Ramezani, Maryam Kouchak, Mohsen Amini, Kambiz Ahmadi Angali, Sadegh Saremy, Farid Abedin Dorkoosh. A novel 5-Fluorouracil targeted delivery to colon cancer using folic acid conjugated liposomes. Biomedicine & Pharmacotherapy. 2018; 108 ():1259-1273.

Chicago/Turabian Style

Somayeh Handali; Eskandar Moghimipour; Mohsen Rezaei; Zahra Ramezani; Maryam Kouchak; Mohsen Amini; Kambiz Ahmadi Angali; Sadegh Saremy; Farid Abedin Dorkoosh. 2018. "A novel 5-Fluorouracil targeted delivery to colon cancer using folic acid conjugated liposomes." Biomedicine & Pharmacotherapy 108, no. : 1259-1273.

Evaluation study
Published: 01 October 2018 in Journal of Food and Drug Analysis
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Extraction of bisphosphonates from biological fluids is important and time consuming step in sample preparation procedure. This paper describes a simple and green sample preparation technique for dispersive micro solid phase extraction (DMSPE) of alendronate sodium (ALS) from urine and serum samples prior to direct spectrofluorimetry (DSFL) and high performance liquid chromatography with fluorescence detection (HPLC-FLD), respectively. The DMSPE strategy is based on the selective chemisorption of ALS on zirconia nanoparticles (ZNPs) as an adsorbent followed by derivatization of the eluted analyte using o-phthalaldehyde (OPA) in the presence of 2-mercaptoethanol (2ME) at basic medium to form fluorescent species. The chemical and instrumental influencing parameters on DMSPE and measuring methods were optimized for the efficient extraction and determination of ALS. The presented methods were capable of extracting ALS from human urine and serum samples and determining over the wide ranges of 5-1000 and 5-2500 μg L with limits of detection (LOD) of 1.5 and 1.4 μg L for DSFL and HPLC methods, respectively. The relative recoveries for the three spiked standard levels of ALS in urine and serum samples ranged from 89.0% to 107.0%, and the intra-day relative standard deviations (%RSDs) were in the range of 2.9-7.9%.

ACS Style

Nadereh Rahbar; Ladan Nazernezhad; Maryam Asadinezhad; Zahra Ramezani; Maryam Kouchak. A novel micro-extraction strategy for extraction of bisphosphonates from biological fluids using zirconia nanoparticles coupled with spectrofluorimetry and high performance liquid chromatography. Journal of Food and Drug Analysis 2018, 26, 1303 -1311.

AMA Style

Nadereh Rahbar, Ladan Nazernezhad, Maryam Asadinezhad, Zahra Ramezani, Maryam Kouchak. A novel micro-extraction strategy for extraction of bisphosphonates from biological fluids using zirconia nanoparticles coupled with spectrofluorimetry and high performance liquid chromatography. Journal of Food and Drug Analysis. 2018; 26 (4):1303-1311.

Chicago/Turabian Style

Nadereh Rahbar; Ladan Nazernezhad; Maryam Asadinezhad; Zahra Ramezani; Maryam Kouchak. 2018. "A novel micro-extraction strategy for extraction of bisphosphonates from biological fluids using zirconia nanoparticles coupled with spectrofluorimetry and high performance liquid chromatography." Journal of Food and Drug Analysis 26, no. 4: 1303-1311.

Journal article
Published: 15 September 2018 in Microchemical Journal
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A novel solid-phase microextraction (SPME) fiber based on a capillary glass tube coated with magnetic Fe3O4/Cu3(BTC)2 metal organic frameworks nanocomposite was prepared by sol–gel technique. The magnetic Fe3O4/Cu3(BTC)2 metal organic frameworks nanocomposite were synthesized by a simple hydrothermal reaction and the resultant powder was mixed with sol–gel precursors to prepare sol–gel solution of the magnetic Fe3O4/Cu3(BTC)2 coating material. In this study, glass tubes with a specific diameter were used as substrates. The magnetic Fe3O4/Cu3(BTC)2 MOF nanocomposites coating was characterized using Fourier transform infrared (FTIR) spectroscopy, powder X-ray diffraction (XRD) and scanning electron microscopy (SEM). Then, the synthesized fiber as novel solid-phase microextraction (SPME) fiber combined with high-performance liquid chromatography (SPME–HPLC) was applied for the determination and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, diclofenac, naproxen and nalidixic acid) in real samples including human urine, serum, plasma, and tablet formulation. To found optimum microextraction conditions, the influences of effective variables were investigated using one-factor-at-a-time experiments and the significant variables were optimized using a Box–Behnken design (BBD) combined with desirability function. Under optimized conditions, calibration graphs of analytes were linear in a concentration range of 0.1–400 μg L−1 with correlation coefficients >0.9966. Limits of detection and quantification were in the ranges of 0.03–0.0 5 μg L−1 and 0.12–0.18 μg L−1, respectively. This procedure was successfully employed in determining target analytes in spiked human urine, serum, plasma, and tablet samples with recoveries ranged from 94.0 to 102.0%.

ACS Style

Roya Mirzajani; Fatemeh Kardani; Zahra Ramezani. Preparation and characterization of magnetic metal–organic framework nanocomposite as solid-phase microextraction fibers coupled with high-performance liquid chromatography for determination of non-steroidal anti-inflammatory drugs in biological fluids and tablet formulation samples. Microchemical Journal 2018, 144, 270 -284.

AMA Style

Roya Mirzajani, Fatemeh Kardani, Zahra Ramezani. Preparation and characterization of magnetic metal–organic framework nanocomposite as solid-phase microextraction fibers coupled with high-performance liquid chromatography for determination of non-steroidal anti-inflammatory drugs in biological fluids and tablet formulation samples. Microchemical Journal. 2018; 144 ():270-284.

Chicago/Turabian Style

Roya Mirzajani; Fatemeh Kardani; Zahra Ramezani. 2018. "Preparation and characterization of magnetic metal–organic framework nanocomposite as solid-phase microextraction fibers coupled with high-performance liquid chromatography for determination of non-steroidal anti-inflammatory drugs in biological fluids and tablet formulation samples." Microchemical Journal 144, no. : 270-284.

Original paper
Published: 22 August 2018 in Journal of the Iranian Chemical Society
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A novel monolithic molecularly imprinted polymer fiber-solid phase microextraction method was developed for the simultaneous determination of cholesterol and β-sitosterol in cow milk, egg yolk and olive oil samples by high-performance liquid chromatography. A flexible MIP monolithic fibers with high chemical and thermal stabilities were simply synthesized using a narrow bore silica capillary as a mold by the copolymerization of methacrylic acid and ethylene glycol dimethacrylate imprinted with β-sitosterol. The prepared MIPs were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM). The main factors that affect the extraction efficiency, such as extraction time, desorption time, desorption solvent, and stirring rate were investigated and optimized. Under the optimized extraction conditions, the limits of detection of the proposed method were 0.03 µg L−1 and 0.05 µg L−1, for cholesterol and β-sitosterol, respectively. Satisfactory linearity was achieved in the range of 0.1–20 µg L−1 for analytes with the correlation coefficients (r) above 0.9975 and RSD less than 3.5%. This procedure was successfully applied for the determination of cholesterol and β-sitosterol in different food samples.

ACS Style

Fatemeh Kardani; Roya Mirzajani; Zahra Ramezani. Direct cholesterol and β-sitosterol analysis in food samples using monolithic molecularly-imprinted solid-phase microextraction fibers coupled with high performance liquid chromatography. Journal of the Iranian Chemical Society 2018, 15, 2877 -2888.

AMA Style

Fatemeh Kardani, Roya Mirzajani, Zahra Ramezani. Direct cholesterol and β-sitosterol analysis in food samples using monolithic molecularly-imprinted solid-phase microextraction fibers coupled with high performance liquid chromatography. Journal of the Iranian Chemical Society. 2018; 15 (12):2877-2888.

Chicago/Turabian Style

Fatemeh Kardani; Roya Mirzajani; Zahra Ramezani. 2018. "Direct cholesterol and β-sitosterol analysis in food samples using monolithic molecularly-imprinted solid-phase microextraction fibers coupled with high performance liquid chromatography." Journal of the Iranian Chemical Society 15, no. 12: 2877-2888.