Sharath Shankar sarojini

Dr. Sharath Shankar sarojini

Department of Medicine, Thomas Jefferson University, Jefferson Alumni Hall, 1020 Locust Street, Philadelphia, PA 19107, USA
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Research Focus & Metrics

Academic Career Length

17Years (2010-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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21 May 2021 in Polymers
Verified
Journal Article
Open access
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SEsreelekha Ediyilyam
sreelekha Ediyilyam
BGBini George
Bini George
SSSharath Shankar sarojini
Sharath Shankar sarojini
TDThomas Thuruthiyil Dennis
Thomas Thuruthiyil Dennis
Stanisław WacławekStanisław Wacławek
Stanisław Wacławek
Vinod PadilVinod Padil
Vinod Padil
The food packaging industry explores economically viable, environmentally benign, and non-toxic packaging materials. Biopolymers, including chitosan (CH) and gelatin (GE), are considered a leading replacement for plastic packaging materials, with preferred packaging functionality and biodegradability. CH, GE, and different proportions of silver nanoparticles (AgNPs) are used to prepare novel packaging materials using a simple solution casting method. The functional and morphological characterization of the prepared films was carried out by using Fourier transform infrared spectroscopy (FTIR), UV–Visible spectroscopy, and scanning electron microscopy (SEM). The mechanical strength, solubility, water vapor transmission rate, swelling behavior, moisture retention capability, and biodegradability of composite films were evaluated. The addition of AgNPs to the polymer blend matrix improves the physicochemical and biological functioning of the matrix. Due to the cross-linking motion of AgNPs, it is found that the swelling degree, moisture retention capability, and water vapor transmission rate slightly decrease. The tensile strength of pure CH–GE films was 24.4 ± 0.03, and it increased to 25.8 ± 0.05 MPa upon the addition of 0.0075% of AgNPs. The real-time application of the films was tested by evaluating the shelf-life existence of carrot pieces covered with the composite films. The composite film containing AgNPs becomes effective in lowering bacterial contamination while comparing the plastic polyethylene films. In principle, the synthesized composite films possessed all the ideal characteristics of packaging material and were considered biodegradable and biocompatible food packaging material and an alternate option for petroleum-based plastics.

22 November 2018 in ACS Applied Materials & Interfaces
Verified
Journal Article
Closed access
SSSharath Shankar sarojini
Sharath Shankar sarojini
RSRayammarakkar M. Shereema
Rayammarakkar M. Shereema
RRRaghavan Baby Rakhi
Raghavan Baby Rakhi

16 November 2017 in Journal of Cellular Physiology
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Journal Article
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TST. V. Sruthi
T. V. Sruthi
LELincy Edatt
Lincy Edatt
GRGrace R. Raji
Grace R. Raji
HKHaritha Kunhiraman
Haritha Kunhiraman
SSSharath Shankar sarojini
Sharath Shankar sarojini
SKSAMEER KUMAR
SAMEER KUMAR

13 June 2021 in Nanomaterials
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Journal Article
Open access
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SNSajina Narath
Sajina Narath
SKSUPIN K K
SUPIN K K
SSSharath Shankar sarojini
Sharath Shankar sarojini
BGBini George
Bini George
Vasundhara MuttaVasundhara Mutta
Vasundhara Mutta
Rajender S. VarmaRajender S. Varma
Rajender S. Varma
A facile green synthetic method is proposed for the synthesis of zinc oxide nanoparticles (ZnO NPs) using the bio-template Cinnamomum tamala (C. tamala) leaves extract. The morphological, functional, and structural characterization of synthesized ZnO NPs were studied by adopting different techniques such as energy dispersive X-ray analysis (EDX), high-resolution transmission electron microscopy (HR-TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), UV-Visible spectroscopy, fourier transform infrared (FTIR) spectroscopy, raman spectroscopy, and X-ray photoelectron spectroscopy (XPS). The fabricated ZnO NPs exhibit an average size of 35 nm, with a hexagonal nanostructure. Further, the well-characterized ZnO NPs were employed for the photocatalytic degradation of methylene blue (MB) in an aqueous solution. The photocatalytic activity was analyzed by changing the various physicochemical factors such as reaction time, amount of photocatalyst, precursor concentration, and calcination temperature of the ZnO NPs. All the studies suggest that the ZnO synthesized through the green protocol exhibits excellent photocatalytic potency against the dye molecules.

30 April 2019 in ACS Omega
Verified
Journal Article
Open access
SSSharath Shankar sarojini
Sharath Shankar sarojini
RSRayamarakkar M. Shereema
Rayamarakkar M. Shereema
VRVishnu Ramachandran
Vishnu Ramachandran
TST. V. Sruthi
T. V. Sruthi
SKSAMEER KUMAR
SAMEER KUMAR
RRR. B. Rakhi
R. B. Rakhi
A carbon quantum dot-based carbon paste electrode was fabricated and used for the determination of adrenaline (AD) at the nanomolar level. This fabricated electrode exhibited tremendous electrocatalytic activity for the oxidation of adrenaline in supporting electrolyte (PBS of pH 7.4). Scan rate variation studies with the modified electrode revealed that the overall electrode process was controlled by a diffusion process. A lower detection limit of 6 nM was achieved by chronoamperometry. Interference by biological molecules such as serotonin (5-HT) and ascorbic acid (AA) in the electrochemical oxidation of AD on the fabricated electrode was tested. It was observed that with the modified electrode, the selective determination of AD was possible. Further, with the fabricated electrode, simultaneous analysis of AA, AD, and 5-HT was performed, and it was observed that the overlapped peaks of these analytes on the naked electrode were well resolved into three peaks on the modified electrode. Along with decent sensitivity and selectivity, the electrode also showed higher stability and antifouling nature. The real-time application of the projected scheme was proven by employing the said electrode for adrenaline in adrenaline bitartrate injections.

6 October 2015 in Biochemistry
Verified
Journal Article
Open access
RSR. M. Shereema
R. M. Shereema
TST. V. Sruthi
T. V. Sruthi
SKSAMEER KUMAR
SAMEER KUMAR
TRT. P. Rao
T. P. Rao
SSSharath Shankar sarojini
Sharath Shankar sarojini
A simple method was employed for the synthesis of green luminescent carbon quantum dots (CQDs) from styrene soot. The CQDs were characterized by transmission electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared, and Raman spectroscopy. The prepared carbon quantum dots did not show cellular toxicity and could successfully be used for labeling cells. We also evaluated the effects of carbon quantum dots on the process of angiogenesis. Results of a chorioallantoic membrane (CAM) assay revealed the significant decrease in the density of branched vessels after their treatment with CQDs. Further application of CQDs significantly downregulated the expression levels of pro-angiogenic growth factors like VEGF and FGF. Expression of VEGFR2 and levels of hemoglobin were also significantly lower in CAMs treated with CQDs, indicating that the CQDs inhibit angiogenesis. Data presented here also show that CQDs can selectively target cancer cells and therefore hold potential in the field of cancer therapy.