In this study we aim to highlight the spatial differences, intensity and frequency of causes of death associated with a range of diseases and the implications of the socio-economic impact on healthcare worldwide between 1990 and 2017: (1) Background: At the same time, an attempt was made to find regional spatial patterns that may be typical for a given geographical area, based on the assumption that global health care is in a permanent state of uncertainty as developed countries have a different morbidity profile than emerging or developing countries. (2) Methods: Using information provided by Global Burden of Disease Collaborative Network, Our World in Data and the World Bank, a multidimensional analysis was carried out, comprising four types of statistical models: grouping analysis, principal component analysis (PCA) Bravais–Pearson linear correlation and multivariate regression. (3) Results: The results confirm the hypothesis of significant correlations between the frequency of causes of death, quality of health care and quality of public health infrastructure, validated by incidence with socio-economic indicators. The study contributes to the literature by analysing trends in the spatial distribution of causes of death worldwide, detecting regional differentiations and testing how socio-economic factors may limit the incidence of morbidity.