Orally administered collagen peptides could contribute to antiaging by replacing the degraded extracellular matrix proteins caused by photoaging. This study aimed to evaluate the efficacy and safety of low-molecular-weight collagen peptides for treating photoaged and dry skin. In this randomized, placebo-controlled, parallel-group, double-blinded trial, we randomly assigned study participants (n = 100) to either the test product group or placebo group at a 1:1 ratio for 12 weeks. The wrinkle scale score, eye wrinkle volume, roughness parameters, such as the average maximum height of the wrinkle (Rz), arithmetic average within the total measuring length of the wrinkle (Ra), maximum profile valley depth of the wrinkle (Rv), and skin hydration, transepidermal water loss (TEWL), overall elasticity (R2), and ratio of elastic recovery to total deformation (R7) were evaluated at baseline, 6 weeks, and 12 weeks. Safety assessments with serial blood tests were also conducted. Efficacy assessments of data from 84 participants were conducted as the per-protocol analysis. After 12 weeks, the 10-grade crow's feet photo scale score, eye wrinkle volume, skin roughness parameters (Rz, Ra, and Rv), skin elasticity (R2 and R7), skin hydration, and TEWL were significantly improved in the test product group compared to the placebo group. There were no adverse events or abnormalities according to laboratory analysis associated with using the test material during the study period. This study showed that the oral supplementation of low-molecular-weight collagen peptides could improve the wrinkles, elasticity, hydration, and barrier integrity of photoaged facial skin. This clinical study was registered with the Korean Clinical Research Information Service and International Clinical Trials Registry Platform (No: KCT0006500).

The purposes of this study were to characterise the golfer–ground interactions during the swing and to identify meaningful associations between the golfer–ground interaction force/moment parameters and the maximum clubhead speed in 63 highly skilled male golfers (handicap ≤ 3). Golfers performed shots in 3 club conditions (driver, 5-iron and pitching wedge) which were captured by an optical motion capture system and 2 force plates. In addition to the ground reaction forces (GRFs), 3 different golfer–ground interaction moments (GRF moments, pivoting moments and foot contact moments) were computed. The GRF moment about the forward/backward (F/B) axis and the pivoting moment about the vertical axis were identified as the primary moments. Significant (p < 0.05) correlations of peak force parameters (all components in the lead foot and F/B component in the trail foot) and peak moment parameters (lead-foot GRF moment and trail-foot pivoting moment) to clubhead speed were found. The lead-foot was responsible for generating the GRF moment, while the trail foot contributed to the pivoting moment more. The instant the lead arm becomes parallel to the ground was identified as the point of maximum angular effort, and the loading onto the lead-foot near this point was critical in generating both peak moments.

Kim J, et al. Yonsei Med J. 2023 Dec;64(12):721-729. https://doi.org/10.3349/ymj.2023.0234

Aging-associated dermatological pigmentary diseases are associated with accumulation of senescence cells and the disruption of basement membrane due to chronic ultraviolet radiation (UVR) exposure. Our study is on the synergistic effect of the novel 300 μm needle-depth fractional microneedling radiofrequency (FMR) treatment and conventional Q-switched ND:YAG laser on aging-associated hyperpigmentation of the skin. The prospective controlled clinical trial of 25 Asian women revealed significantly higher improvements not only on wrinkles, but also on hyperpigmentation. Additional ex vivo study revealed significant reduction of pro-melanogenic markers as well as senescent keratinocytes, while increased expression of collagen type IV on the epidermal basement membrane, after additional FMR treatment on UV-irradiated human tissues. These results demonstrate that 300 μm needle-depth FMR might effectively remove senescent keratinocytes that secrete pro-melanogenic markers, and repair disrupted basement membrane, therefore preventing constant hyperpigmentation of the aged skin.