Non-steroidal anti-inflammatory drugs (NSAIDs) and endocrine disruptors (EDCs) are among the most important categories of contaminants of emerging concern (CECs), and many advanced technologies have been developed for their elimination from water and wastewater, including nano-zero valent iron (nZVI). This study investigates the performance of nZVI synthesized from green tea extracts and incorporated into a cationic resin (R-nFe) in the removal of four selected NSAIDs, namely ibuprofen (IBU), naproxen (NPX), diclofenac (DCF), and ketoprofen (KFN), and an EDC, namely bisphenol A (BPA). Column experiments were conducted to evaluate the effect of various operating parameters, including initial CECs concentration, contact time, pH, addition, and dose of sodium persulfate (PS). To the authors’ knowledge, this is the first time that environmentally friendly produced nZVI has been combined with PS in column experiments for the removal of CECs from wastewater. With a contact time of 2.2 min, PS = 1 mM, and influent pH = 3.5, 27–72% of IBU, 70–99% of NPX, 70–95% of DCF, 28–50% of KFN, and 61–91% of BPA were removed during a 12-day operation of the system, while the initial concentration of each substance was 5 μg/L. Therefore, it is anticipated that the proposed system could be a promising post-treatment technology for the removal of CECs from wastewater.